Fol. Biol. 2001, 47, 11-13
Cytotoxic Effects of Colicins E1 and E3 on v-myb-Transformed Chicken Monoblasts
Colicins show a considerable cytostatic activity, which is much less known and understood than their killing activity targeting bacteria of the Enterobacteriaceae family. In this communication, the cytotoxic effects of colicins E1 and E3 on v-myb-transformed chicken monoblasts BM2 are presented. We detected clear reduction of the viable cell number induced by colicins E1 and E3, occurring without apparent changes in cell cycle profiles. The level of inhibition was proportional to the colicin concentration within the limits of 0.5-1.25 μg/ml. This result documents that colicins produced by Enterobacteriaceae exert their cytotoxic effects on leukemic cells.
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Funding
This work was supported by the grant No. 310/98/0083 from the Grant Agency of the Czech Republic and the grant No. MSM 143100008 from the Ministry of Education, Youth and Sport of the Czech Republic.
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This is an open-access article distributed under the terms of the Creative Commons Attribution License.