Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2001, 47, 187-195

https://doi.org/10.14712/fb2001047060187

Expression of Human Erythropoietin Gene in the Mammary Gland of a Transgenic Mouse

Tomáš Mikuš, P. Malý, M. Poplštein, V. Landa, P. Trefil, J. Lidický

Biopharm Research Institute of Biopharmacy and Veterinary Drugs, Inc., Pohoří - Chotouň, Jílové u Prahy, Czech Republic

Received November 2000
Accepted August 2001

References

1. Aguirre, A., Castro-Palomino, N., De la Fuente, J., Ovidio Castro, F. O. (1998) Expression of human erythropoietin transgenes and of the endogenous WAP gene in the mammary gland of transgenic rabbits during gestation and lactation. Transgenic Res. 7, 311-317. <https://doi.org/10.1023/A:1008882332133>
2. Andres, A. C., Schonenberger, C. A., Groner, B., Henninghausen, L., LeMeur, M., Gerlinger, P. (1987) Haras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc. Natl. Acad. Sci. USA 84, 1299-1303. <https://doi.org/10.1073/pnas.84.5.1299>
3. Bayna, E. M., Rosen, J. M. (1990) Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice. Nucleic Acids Res. 18, 2977-2985. <https://doi.org/10.1093/nar/18.10.2977>
4. Bischoff, R., Degryse, E., Perraud, F., Dalemans, W., Ali-Hadji, D., Thepot, D., Devinoy, E., Houdebine, L. M., Pavirani, A. (1992) A 17.6 kbp region located upstream of the rabbit WAP gene directs high level expression of a functional human protein variant in transgenic mouse milk. FEBS Lett. 305, 265-268. <https://doi.org/10.1016/0014-5793(92)80683-8>
5. Brem, G., Brenig, B., Salmons, B., Wolf, E., Muller, M., Erfle, V., Gunzburg, W. H., Dahme, E. (1991) Unexpected transgene expression of a mammary-specific growth hormone gene construct in Bergmann glial cells of the mouse. Tierarztl. Prax. 19, 345-350.
6. Brinster, R. L., Allen, J. M., Behringer, R. R., Gelinas, R. E., Palmiter, R. D. (1988) Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. USA 85, 836-840. <https://doi.org/10.1073/pnas.85.3.836>
7. Burdon, T., Sankaran, L., Wall, R. J., Spencer, M., Hennighausen, L. (1991) Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation. J. Biol. Chem. 266, 6909-6914. <https://doi.org/10.1016/S0021-9258(20)89588-X>
8. Castro, F. O., Limonta, J., Rodriguez, A., Aguirre, A., de la Fuente, J., Aguilar, A., Ramos, B., Hayes, O. (1999) Transgenic rabbits for the production of biologicallyactive recombinant proteins in the milk. Genet. Anal. 15, 179-187. <https://doi.org/10.1016/S1050-3862(99)00024-8>
9. Choi, T., Huang, M., Gorman, C., Jaenisch, R. (1991) A generic intron increases gene expression in transgenic mice. Mol. Cell. Biol. 11, 3070-3074.
10. Dale, T. C., Krnacik, M. J., Schmidhauser, C., Yang, C. L., Bissell, M. J., Rosen, J. M. (1992) High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region. Mol. Cell. Biol. 12, 905-914.
11. Dandekar, A. M., Robinson, E. A., Appella, E., Qasba, P. K. (1982) Complete sequence analysis of cDNA clones encoding rat whey phosphoprotein: homology to a protease inhibitor. Proc. Natl. Acad. Sci. USA 79, 3987-3991. <https://doi.org/10.1073/pnas.79.13.3987>
12. Devinoy, E., Hubert, C., Jolivet, G., Thepot, D., Clergue, N., Desaleux, M., Dion, M., Servely, J. L. Houdebine, L. M. (1988) Recent data on the structure of rabbit milk protein genes and on the mechanism of the hormonal control of their expression. Reprod. Nutr. Dev. 28, 1145-1164. <https://doi.org/10.1051/rnd:19880711>
13. Devinoy, E., Malienou-N'Gassa, R., Thepot, D., Puissant, C., Houdebine, L. M. (1991) Hormone responsive elements within the upstream sequences of the rabbit whey acidic protein (WAP) gene direct chloramphenicol acetyl transferase (CAT) reporter gene expression in transfected rabbit mammary cells. Mol. Cell. Endocrinol. 81, 185-193. <https://doi.org/10.1016/0303-7207(91)90217-G>
14. Devinoy, E., Thepot, D., Stinnakre, M. G., Fontaine, M. L., Grabowski, H., Puissant, C., Pavirani, A., Houdebine, L. M. (1994) High level production of human growth hormone in the milk of transgenic mice: the upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland. Transgenic Res. 3, 79-89. <https://doi.org/10.1007/BF01974085>
15. Erslev, A. (1953) Humoral regulation of red cell production. Blood 8, 349-357. <https://doi.org/10.1182/blood.V8.4.349.349>
16. Gordon, K., Lee, E., Vitale, J. A., Smith, A. E., Westphal, H. Hennighausen, L. (1987) Production of human tissue plasminogen activator in transgenic mouse milk. Biotechnology 5, 1183-1187.
17. Grabowski, H., Le Bars, D., Chene, N., Attal, J., Malienou-Ngassa, R., Puissant, C. Houdebine, L.M. (1991) Rabbit whey acidic protein concentration in milk, serum, mammary gland extract, and culture medium. J. Dairy Sci. 74, 4143-4150. <https://doi.org/10.3168/jds.S0022-0302(91)78609-8>
18. Gunzburg, W. H., Salmons, B., Zimmermann, B., Muller, M., Erfle, V., Brem, G. (1991) A mammary-specific promoter directs expression of growth hormone not only to the mammary gland, but also to Bergman glia cells in transgenic mice. Mol. Endocrinol. 5, 123-133. <https://doi.org/10.1210/mend-5-1-123>
19. Hennighausen, L. G., Sippel, A. E., Hobbs, A. A., Rosen, J. M. (1982) Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein. Nucleic Acids Res. 10, 3733-3744. <https://doi.org/10.1093/nar/10.12.3733>
20. Hogan, B., Beddington, R., Constantini, F., Lacy, E. (1994) Manipulating the mouse embryo. In: A Laboratory Manual, Cold Spring Harbor Laboratory, New York.
21. Jacobs, K., Shoemaker, C., Rudersdorf, R., Neill, S. D., Kaufman, R. J., Mufson, A., Seehra, J., Jones, S. S., Hewick, R., Fritsch, E. F. (1985) Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 313, 806-810. <https://doi.org/10.1038/313806a0>
22. Jelkmann, W. (1992) Erythropoietin: structure, control of production, and function. Physiol. Rev. 72, 449-489. <https://doi.org/10.1152/physrev.1992.72.2.449>
23. Kolb, A. F., Gunzburg, W. H., Albang, R., Brem, G., Erfle, V., Salmons, B. (1994) Negative regulatory element in the mammary specific whey acidic protein promoter. J. Cell. Biochem. 56, 245-261. <https://doi.org/10.1002/jcb.240560219>
24. Kolb, A. F., Albang, R., Brem, G., Erfle, V., Gunzburg, W. H., Salmons, B. (1995) Characterization of a protein that binds a negative regulatory element in the mammary-specific whey acidic protein promoter. Biochem. Biophys. Res. Commun. 217, 1045-1052. <https://doi.org/10.1006/bbrc.1995.2875>
25. Lacombe, C., Da Silva, J. L., Bruneval, P., Camilleri, J. P., Bariety, J., Tambourin, P., Varet, B. (1988) Identification of tissues and cells producing erythropoietin in the anemic mouse. Contrib. Nephrol. 66, 17-24. <https://doi.org/10.1159/000416000>
26. Li, S., Rosen, J. M. (1994) Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region. Mol. Endocrinol. 8, 1328-1335.
27. Limonta, J., Pedraza, A., Rodriguez, A., Freyre, F. M., Barral, A. M., Castro, F. O., Lleonart, R., Gracia, C. A., Gavilondo, J. V., de la Fuente, J. (1995a) Production of active anti-CD6 mouse/human chimeric antibodies in the milk of transgenic mice. Immunotechnology 1, 107-113. <https://doi.org/10.1016/1380-2933(95)00010-0>
28. Limonta, J. M., Castro, F. O., Martinez, R., Puentes, P., Ramos, B., Aguilar, A., Lleonart, R. L., de la Fuente, J. (1995b) Transgenic rabbits as bioreactors for the production of human growth hormone. J. Biotechnol. 40, 49-58. <https://doi.org/10.1016/0168-1656(95)00026-M>
29. Lin, F. K., Suggs, S., Lin, C. H., Browne, J. K., Smalling, R., Egrie, J. C., Chen, K. K., Fox, G. M., Martin, F., Stabinsky, Z., (1985) Cloning and expression of the human erythropoietin gene. Proc. Natl. Acad. Sci. USA 82, 7580-7584. <https://doi.org/10.1073/pnas.82.22.7580>
30. Malý, P., Thall, A., Petryniak, B., Rogers, C. E., Smith, P. L., Marks, R. M., Kelly, R. J., Gersten, K. M., Cheng, G., Saunders, T. L., Camper, S. A., Camphausen, R. T., Sullivan, F. X., Isogai, Y., Hindsgaul, O., von Andrian, U. H., Lowe, J. B. (1996) The α(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role of in L-, E- and P-selectin ligand biosynthesis. Cell 86, 643-653. <https://doi.org/10.1016/S0092-8674(00)80137-3>
31. Massoud, M., Bischoff, R., Dalemans, W., Pointu, H., Attal, J., Schultz, H., Clesse, D., Stinnakre, M. G., Pavirani, A., Houdebine, L. M. (1991) Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits. J. Biotechnol. 18, 193-203. <https://doi.org/10.1016/0168-1656(91)90247-S>
32. Massoud, M., Attal, J., Thepot, D., Pointu, H., Stinnakre, M. G., Theron, M. C., Lopez, C., Houdebine, L. M. (1996) The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reprod. Nutr. Dev. 36, 555-563. <https://doi.org/10.1051/rnd:19960511>
33. Palmiter, R. D., Sandgren, E. P., Avarbock, M. R., Allen, D. D., Brinster, R. L. (1991) Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci. USA 88, 478-482. <https://doi.org/10.1073/pnas.88.2.478>
34. Palmiter, R. D., Sandgren, E. P., Koeller, D. M., Brinster, R. L. (1993) Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell. Biol. 13, 5266-5275.
35. Piletz, J. E., Heinlen, M., Ganschow, R. E. (1981) Biochemical characterization of a novel whey protein from murine milk. J. Biol. Chem. 256, 11509-11516. <https://doi.org/10.1016/S0021-9258(19)68430-9>
36. Pittius, C. W., Hennighausen, L., Lee, E., Westphal, H., Nicols, E., Vitale, J., Gordon, K. (1988) A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc. Natl. Acad. Sci. USA 85, 5874-5878. <https://doi.org/10.1073/pnas.85.16.5874>
37. Pollock, D. P., Kutzko, J. P., Birck-Wilson, E., Williams, J. L., Echelard, X., Meade, H. M. (1999) Transgenic milk as a method for the production of recombinant antibodies. J. Immunol. Methods 231, 147-157. <https://doi.org/10.1016/S0022-1759(99)00151-9>
38. Rodriguez, A., Castro, F. O., Aguilar, A., Ramos, B., Del Barco, D. G., Leonart R., De la Fuente, J. (1995) Expression of active human erythropoietin in the mammary gland of lactating transgenic mice and rabbits. Biol. Res. 28, 141-153.
39. Sambrook, J., Fritsch, E. F., Maniatis, T. (1989) Molecular Cloning: Laboratory Manual 2nd ed. Cold Spring Harbor Laboratory Press.
40. Sohn, B. H., Kim, S. J., Park, H., Park, S. K., Lee, S. C., Hong, H. J., Park, Y. S., Lee, K. K. (1999) Expression and characterization of bioactive human thrombopoietin in the milk of transgenic mice. DNA Cell. Biol. 18, 845-852. <https://doi.org/10.1089/104454999314845>
41. Thall, A. D., Malý, P., Lowe, J. B. (1995) Oocyte Galα1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J. Biol. Chem. 270, 21437-21440. <https://doi.org/10.1074/jbc.270.37.21437>
42. Thepot, D., Devinoy, E., Fontaine, M. L., Hubert, C., Houdebine, L. M. (1990) Complete sequence of the rabbit whey acidic protein gene. Nucleic Acids Res. 18, 3641. <https://doi.org/10.1093/nar/18.12.3641>
43. Thepot, D., Devinoy, E., Fontaine, M. L., Stinnakre, M. G., Massoud, M., Kann, G., Houdebine, L. M. (1995) Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of transgenic mice. Mol. Reprod. Dev. 42, 261-267. <https://doi.org/10.1002/mrd.1080420302>
44. Tomasetto, C., Wolf, C., Rio, M.C., Mehtali, M., LeMeur, M., Gerlinger, P., Chambon, P., Lathe, R. (1989) Breast cancer protein PS2 synthesis in mammary gland of transgenic mice and secretion into milk. Mol. Endocrinol. 3, 1579-1584. <https://doi.org/10.1210/mend-3-10-1579>
45. Velander, W. H., Page, R. L., Morcol, T., Russell, C. G., Canseco, R., Young, J. M., Drohan, W. N., Gwazdauskas, F. C., Wilkins, T. D., Johnson, J. L. (1992) Production of biologically active human protein C in the milk of transgenic mice. Ann. N. Y. Acad. Sci. 665, 391-403. <https://doi.org/10.1111/j.1749-6632.1992.tb42602.x>
46. van Kuik-Romeijn, P., de Groot, N., Hooijberg, E., de Boer, H. A. (2000) Expression of a functional mouse-human chimeric anti-CD19 antibody in the milk of transgenic mice. Transgenic Res. 9, 145-154.
47. Yu, S. H., Deen, K. C., Lee, E., Hennighausen, L.., Sweet, R. W., Rosenberg, M., Westphal, H. (1989) Functional human CD4 protein produced in milk of transgenic mice. Mol. Biol. Med. 6, 255-261.
48. Zanjani, E. D., Mann, L. I., Burlington, H., Gordon, A. S., Wasserman, L. R. (1974) Evidence for a physiologic role of erythropoietin in fetal erythropoiesis. Blood 44, 285-290. <https://doi.org/10.1182/blood.V44.2.285.285>
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