Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2001, 47, 215-217

https://doi.org/10.14712/fb2001047060215

New Monoclonal Antibodies Recognizing the Adaptor Protein LAT

P. Tolar, M. Tůmová, Petr Dráber

Department of Mammalian Genes Expression, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Received July 2001
Accepted August 2001

References

1. Finco, T. S., Kadlecek, T., Zhang, W., Samelson, L. E., Weiss, A. (1998) LAT is required for TCR-mediated activation of PLCγl and the Ras pathway. Immunity 9, 617-626. <https://doi.org/10.1016/S1074-7613(00)80659-7>
2. Gringhuis, S. I., Leow, A., Papendrecht-Van Der Voort, E. A., Remans, P. H., Breedveld, F. C., Verweij, C. L. (2000) Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis. J. Immunol. 164, 2170-2179. <https://doi.org/10.4049/jimmunol.164.4.2170>
3. Saitoh, S., Arudchandran, R., Manetz, T. S., Zhang, W., Sommers, C. L., Love, P. E., Rivera, J., Samelson, L. E. (2000) LAT is essential for Fc&RI-mediated mast cell activation. Immunity 12, 525-535. <https://doi.org/10.1016/S1074-7613(00)80204-6>
4. Wange, R. L. (2000) LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Science's Signal Transduction Knowledge Environment. www.stke.org/cgi/content/full/OC_sigtrans;2000/63/re1.
5. Weber, J. R., Orstavik, S., Torgersen, K. M., Danbolt, N. C., Berg, S. F., Ryan, J. C., Tasken, K., Imboden, J. B., Vaage, J. T. (1998) Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 187, 1157-1161. <https://doi.org/10.1084/jem.187.7.1157>
6. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P., Samelson, L. E. (1998a) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92, 83-92. <https://doi.org/10.1016/S0092-8674(00)80901-0>
7. Zhang, W., Trible, R. P., Samelson, L. E. (1998b) LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9, 239-246. <https://doi.org/10.1016/S1074-7613(00)80606-8>
8. Zhang, W., Sommers, C. L., Burshtyn, D. N., Stebbins, C. C., DeJarnette, J. B., Trible, R. P., Grinberg, A., Tsay, H. C., Jacobs, H. M., Kessler, C. M., Long, E. O., Love, P. E., Samelson, L. E. (1999a) Essential role of LAT in T cell development. Immunity 10, 323-332. <https://doi.org/10.1016/S1074-7613(00)80032-1>
9. Zhang, W., Irvin, B. J., Trible, R. P., Abraham, R. T., Samelson, L. E. (1999b) Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int. Immunol. 11, 943-950. <https://doi.org/10.1093/intimm/11.6.943>
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