Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2007, 53, 143-145

https://doi.org/10.14712/fb2007053040143

Risedronate Has No Adverse Effects on Mouse Haematopoiesis

Luděk Šefc1, P. Broulík2, T. Pelichovská1, E. Nečas1

1Institute of Pathophysiology, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic
23rd Medical Department, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic

Received February 2007
Accepted May 2007

Bisphosphonates are commonly used for treatment of osteoporosis. They inhibit osteoclast activity and thus bone resorption. It was shown that they also affect some other cell types including tumour and endothelial cells. The effects of risedronate on bone marrow microenvironment were not studied yet. As endothelial cells are integral part of bone marrow microenvironment, it is important to know whether prolonged administration of bisphosphonates does not affect haematopoietic stem cells and bone marrow haematopoiesis. We fed mice two weeks with risedronate. We found no effect of risedronate treatment on bone marrow stem cells using the method of congenic bone marrow repopulation. Risedronate administration in the dose which is considered to be comparable to a dose of risedronate used for treatment of osteoporosis in women seems to be safe in terms of effects on mouse haematopoiesis.

Funding

This work was supported by project 305/04/1528 granted by the Grant Agency of the Czech Republic and by research projects MSM 0021620806 and LC06044 granted by the Ministry of Education, Youth and Sports of the Czech Republic.

References

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