Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2007, 53, 173-175

https://doi.org/10.14712/fb2007053050173

KCNJ11 E23K Polymorphism and Diabetes Mellitus with Adult Onset in Czech Patients

Pavlína Čejková1, P. Novota1, M. Černá1, K. Kološtová1, D. Nováková2, P. Kučera2, J. Novák3, M. Anděl3, P. Weber4, E. Ždárský5

1Department of Cell and Molecular Biology, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic
2Department of Cell and Molecular Immunology, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic
3Diabetes Center and Department of Internal Medicine, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic
4Department of Internal Medicine, Geriatrics and General Medicine, University Hospital Brno, Czech Republic
5Department of Pharmacology, Charles University in Prague, 3rd Faculty of Medicine, Prague, Czech Republic

Received January 2007
Accepted June 2007

In this work, we studied the association of the E23K polymorphism of the Kir6.2 ATP-sensitive potassium channels in 212 Czech patients with diabetes mellitus who were diagnosed after the age of 35. Patients were classified into T1DM, LADA and T2DM groups based on C-peptide and GADA levels. Carriers of the predisposing Kir6.2 E23K K allele showed no increased risk of either type of diabetes mellitus development. On the other hand, we found a correlation between E23K SNP of the KCNJ11 gene and C-peptide levels, which may be considered a measure of pancreatic β-cell activity, although this correlation was not statistically significant. In conclusion, we failed to confirm the Kir6.2 E23K as a genetic marker for T1DM, LADA and T2DM in the Central Bohemian population of the Czech Republic.

Funding

This study was supported by the Research Programme of the Ministry of Education, Youth and Sports of the Czech Republic MSM 0021620814.

References

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