Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2013, 59, 240-245

https://doi.org/10.14712/fb2013059060240

Hypermethylation of RAD51L3 and XRCC2 Genes to Predict Late Toxicity in Chemoradiotherapy-Treated Cervical Cancer Patients

Simona Paulíková1, M. Chmelařová2, J. Petera1, V. Palička2, A. Paulík1

1Department of Oncology and Radiotherapy, Charles University in Prague – Faculty of Medicine in Hradec Králové and Faculty Hospital Hradec Králové, Czech Republic
2Department of Clinical Biochemistry and Diagnostics, Charles University in Prague – Faculty of Medicine in Hradec Králové and Faculty Hospital Hradec Králové, Czech Republic

Received August 2013
Accepted October 2013

References

1. Borgmann, K., Roper, B., El­Awady, R., Brackrock, S., Bigalke, M., Dörk, T., Alberti, W., Dikomey, E., DahmDaphi, J. (2002) Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother. Oncol. 64, 141-152. <https://doi.org/10.1016/S0167-8140(02)00167-6>
2. Ellenson, L. H., Wu, T. C. (2004) Focus on endometrial and cervical cancer. Cancer Cell 5, 533-538. <https://doi.org/10.1016/j.ccr.2004.05.029>
3. French, C. A., Masson, J. Y., Griffin, C. S., O’Regan, P., West, S. C., Thacker, J. (2002) Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J. Biol. Chem. 277, 19322-19330. <https://doi.org/10.1074/jbc.M201402200>
4. Kawabata, M., Kawabata, T., Nishibori, M. (2005) Role of recA/RAD51 family proteins in mammals. Acta Med. Okayama 59, 1-9.
5. Kitahara, O., Katagiri, T., Tsunoda, T., Harima, Y., Nakamura, Y. (2002) Classification of sensitivity or resistance of cervical cancers to ionizing radiation according to expression profiles of 62 genes selected by cDNA microarray analysis. Neoplasia 4, 295-303. <https://doi.org/10.1038/sj.neo.7900251>
6. Liu, Y., Masson, J. Y., Shah, R., O’Regan, P., West, S. C. (2004) RAD51C is required for Holliday junction processing in mammalian cells. Science 303, 243-246. <https://doi.org/10.1126/science.1093037>
7. Masson, J. Y., Stasiak, A. Z., Stasiak, A., Benson, F. E., West, S. C. (2001) Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Proc. Natl. Acad. Sci. USA 98, 8440-8446. <https://doi.org/10.1073/pnas.111005698>
8. Nygren, A. O., Ameziane, N., Duarte, H. M., Vijzelaar, R. N., Waisfisz, Q., Hess, C. J., Schouten, J. P., Errami, A. (2005) Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res. 33, e128. <https://doi.org/10.1093/nar/gni127>
9. Rieger, K. E., Hong, W. J., Tusher, V. G., Tang, J., Tibshirani, R., Chu, G. (2004) Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Proc. Natl. Acad. Sci. USA 101, 6635-6640. <https://doi.org/10.1073/pnas.0307761101>
10. Sonoda, E., Sasaki, M. S., Buerstedde, J. M., Bezzubova, O., Shinohara, A., Ogawa, H., Takata, M., Yamaguchi­Iwai, Y., Takeda, S. (1998) Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J. 17, 598-608. <https://doi.org/10.1093/emboj/17.2.598>
11. Svensson, J. P., Stalpers, L. J., Esveldt­van Lange, R. E., Franken, N. A., Haveman, J., Klein, B., Turesson, I., Vrieling, H., Giphart-Gassler, M. (2006) Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity. PLoS Med. 3, e422. <https://doi.org/10.1371/journal.pmed.0030422>
12. Thacker, J., Zdzienicka, M. Z. (2004) The XRCC genes: expanding roles in DNA double­strand break repair. DNA Repair (Amst.) 3, 1081-1090. <https://doi.org/10.1016/j.dnarep.2004.04.012>
13. Thacker, J. (2005) The RAD51 gene family, genetic instability and cancer. Cancer Lett. 219, 125-35. <https://doi.org/10.1016/j.canlet.2004.08.018>
14. Turesson, I., Nyman, J., Holmberg, E., Oden, A. (1996) Prognostic factors for acute and late skin reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 36, 1065-1075. <https://doi.org/10.1016/S0360-3016(96)00426-9>
15. Zempolich, K., Fuhrman, C., Milash, B., Flinner, R., Greven, K., Ryu, J., Forbes, A., Kerlin, K., Nichols, R. C., Gaffney, D. K. (2008) Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Gynecol. Oncol. 109, 275-279. <https://doi.org/10.1016/j.ygyno.2008.01.027>
16. Zhu, C., Bogue, M. A., Lim, D. S., Hasty, P., Roth, D. B. (1996) Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86, 379-89. <https://doi.org/10.1016/S0092-8674(00)80111-7>
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