Fol. Biol. 2026, 72, 75-84
https://doi.org/10.14712/fb2026.0008
Clinical Significance and Potential Mechanism of miR-532-5p/CXCL1 Axis in Chronic Obstructive Pulmonary Disease
Yongquan Wang
, Guangming Xiang
, Guangming Xiang
Department of Respiratory and Critical Care Medicine, The People’s Hospital of Yichang City, Yichang 443000, China
Received September 17, 2025
Accepted January 9, 2026
References
1. , A., Celli, B. R., Criner, G. J. et al. (2023) Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur. Respir. J. 61, 2300239.
<https://doi.org/10.1183/13993003.00239-2023>
2. , J. A., Rodrigo-Muñoz, J. M., Sastre, B. et al. (2020) MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease. Front. Immunol. 11, 608666.
<https://doi.org/10.3389/fimmu.2020.608666>
3. , J., Yang, Z., Yuan, Q. et al. (2021) Prediction of gold stage in patients hospitalized with COPD exacerbations using blood neutrophils and demographic parameters as risk factors. BMC Pulm. Med. 21, 329.
<https://doi.org/10.1186/s12890-021-01696-z>
4. , H., Liu, K., Zheng, Y. et al. (2025) Upregulation of ARHGAP18 by miR-613 inhibits cigarette smoke extract-induced apoptosis and epithelial-mesenchymal transition in bronchial epithelial cells. Int. J. Chron. Obstruct. Pulmon. Dis. 20, 2525-2537.
<https://doi.org/10.2147/COPD.S524723>
5. , J., Jiang, W., Tong, X. et al. (2019) Identification of gene and microRNA changes in response to smoking in human airway epithelium by bioinformatics analyses. Medicine (Baltimore) 98, e17267.
<https://doi.org/10.1097/MD.0000000000017267>
6. , Y. J., Wang, K. Y., Chien, W. C. et al. (2025) Paradigm shift in the treatment of chronic obstructive pulmonary disease improves patient outcomes. Int. J. Chron. Obstruct. Pulmon. Dis. 20, 1965-1972.
<https://doi.org/10.2147/COPD.S511593>
7. , M., Mei, H., Zhang, Y. et al. (2025) Expression and regulatory mechanism of miR-34a in neonatal rat model of bronchopulmonary dysplasia induced by hyperoxia. Beijing Da Xue Xue Bao Yi Xue Ban 57, 237-244. (in Chinese)
8. , T., Watanabe, M., Nakamoto, K. et al. (2018) Bronchial epithelial cells produce CXCL1 in response to LPS and TNFα: a potential role in the pathogenesis of COPD. Exp. Lung Res. 44, 323-331.
<https://doi.org/10.1080/01902148.2018.1520936>
9. , M. E., Lee, J. S. (2024) Mechanisms and emerging regulators of neuroinflammation: exploring new therapeutic strategies for neurological disorders. Curr. Issues Mol. Biol. 47, 8.
<https://doi.org/10.3390/cimb47010008>
10. , R. Y., Sunkara, K. P., Bracke, K. R. et al. (2021) A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis. Sci. Transl. Med. 13, eaav7223.
<https://doi.org/10.1126/scitranslmed.aav7223>
11. , S., Zhu, C., Wang, Q. et al. (2022) miR-532-5p inhibits non-small cell lung cancer progression in vivo and in vitro by targeting yin yang 1. Crit. Rev. Eukaryot. Gene Expr. 32, 47-61.
<https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022041766>
12. , X., Jiang, X., Zeng, R. et al. (2024) Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways. Phytother. Res. 38, 1278-1293.
<https://doi.org/10.1002/ptr.8104>
13. , C., Zhu, X., Aga, E. et al. (2024) Ebeiedinone and peimisine inhibit cigarette smoke extract-induced oxidative stress injury and apoptosis in BEAS-2B cells. Cell Stress Chaperones 29, 697-708.
<https://doi.org/10.1016/j.cstres.2024.10.001>
14. , T., Zhang, X., Chen, R. et al. (2025) Uncovering common disease mechanisms and critical biomarkers in Crohn’s disease with concurrent psoriasis and exploring potential therapeutic agents. PLoS One, 20, e0324007.
<https://doi.org/10.1371/journal.pone.0324007>
15. , F., Yao, L. P., Gao, D. D. et al. (2024) MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease through suppressing ZFP36L1 expression and inducing lung fibroblast senescence. Respir. Res. 25, 67.
<https://doi.org/10.1186/s12931-024-02696-3>
16. , Z., Li, L., Wei, L. et al. (2021) Long non-coding RNA LOC366613 alleviates the cerebral ischemic injury via regulating the miR-532-5p/phosphatase and tensin homolog axis. Bioengineered 12, 2511-2522.
<https://doi.org/10.1080/21655979.2021.1930966>
17. , M., Papi, A., Contoli, M. et al. (2021) Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact. Respirology 26, 532-551.
<https://doi.org/10.1111/resp.14041>
18. , S., Li, Z., Badji, H. et al. (2025) Dysfunction of COX-2/mPGES-1/PGE2 pathway and EP4 receptor in bronchi from COPD patients. Prostaglandins Leukot. Essent. Fatty Acids 206, 102685.
<https://doi.org/10.1016/j.plefa.2025.102685>
19. , Y., Niu, H., Meng, X. et al. (2024) Associations between air pollution and the onset of acute exacerbations of COPD: a time-stratified case-crossover study in China. Chest 166, 998-1009.
<https://doi.org/10.1016/j.chest.2024.05.030>
20. , N., Subedi, K., Solone, X. K. et al. (2025) Epigenetic control of alveolar macrophages: impact on lung health and disease. Cells 14, 640.
<https://doi.org/10.3390/cells14090640>
21. , Y. H., Kim, D., Dai, J. et al. (2015) Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis. Toxicol. Appl. Pharmacol. 287, 240-245.
<https://doi.org/10.1016/j.taap.2015.06.008>
22. , X., Hou, G., He, Y. L. et al. (2022) The novel regulatory role of the lncRNA-miRNA-mRNA axis in chronic inflammatory airway diseases. Front. Mol. Biosci. 9, 927549.
<https://doi.org/10.3389/fmolb.2022.927549>
23. , R. M., Harangus, A., Todea, D. A. et al. (2024) Opioids in treatment of refractory dyspnea in chronic obstructive pulmonary disease: yes, no or maybe. J. Pers. Med. 14, 318.
<https://doi.org/10.3390/jpm14030318>
24. , P., Liu, Y., Ren, J. et al. (2024) Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1. Open Med. (Wars.) 19, 20240943.
<https://doi.org/10.1515/med-2024-0943>
25. , K., Mavrovounis, G., Kontopoulou, L. et al. (2025) Unmasking convergent inflammatory and oxidative pathways in asthma. Allergy 80, 1801-1806.
<https://doi.org/10.1111/all.16575>
26. , C., Zhu, Y., Chen, C. et al. (2025) Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning. Front. Med. (Lausanne) 12, 1592802.
<https://doi.org/10.3389/fmed.2025.1592802>
27. , T., Wang, J., Zhao, J. et al. (2022) Current and prospective applications of exosomal microRNAs in pulmonary fibrosis (Review). Int. J. Mol. Med. 49, 37.
<https://doi.org/10.3892/ijmm.2022.5092>
28. , Y., Wang, L., Mutlu, G. M. et al. (2021) More to explore: further definition of risk factors for COPD – differential gender difference, modest elevation in PM2.5, and e-cigarette use. Front. Physiol. 12, 669152.
<https://doi.org/10.3389/fphys.2021.669152>
29. , C., Gao, Y., Ding, P. et al. (2023) The role of CXCL family members in different diseases. Cell Death Discov. 9, 212.
<https://doi.org/10.1038/s41420-023-01524-9>
30. , Y., Hobbs, B. D., Hersh, C. P. et al. (2021) Identifying miRNA-mRNA networks associated with COPD phenotypes. Front. Genet. 12, 748356.
<https://doi.org/10.3389/fgene.2021.748356>
