Fol. Biol. 2026, 72, 128-135
https://doi.org/10.14712/fb2026.0013
The Predictive Value of NLRP3-Mediated Inflammatory Factor Production for Abnormal Liver Function in Pregnant Women with Hepatitis B
Lei Zhang
, Juan Du, Lan Shao, Chunyan Yu, Cuili Yang, Yu Wang, Jinyu Gu
, Juan Du, Lan Shao, Chunyan Yu, Cuili Yang, Yu Wang, Jinyu Gu
Department of Obstetrics and Gynecology, Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, 050000, China
Received October 27, 2025
Accepted March 6, 2026
References
1. , Q., Liu, H., Han, W. et al. (2019) Maternal HBsAg carriers and adverse pregnancy outcomes: a hospital-based prospective cohort analysis. J. Viral Hepat. 26, 1011-1018.
<https://doi.org/10.1111/jvh.13105>
2. , D. C., Wang, X., Griffin, A. et al. (2022) Preeclampsia and COVID-19: the role of inflammasome activation. Curr. Hypertens. Rep. 24, 341-348.
<https://doi.org/10.1007/s11906-022-01195-4>
3. , Z. B., Han, T., Cai, Y. X. et al. (2025) Hepatic steatosis and pyroptosis are induced by the hepatitis B virus X protein via B56α-METTL3 interaction-mediated m6A modification of the NLRP3 mRNA. Cell Death Dis. 16, 698.
<https://doi.org/10.1038/s41419-025-08019-8>
4. on the management of autoimmune hepatitis. (2025) J. Hepatol. 83, 453-501.
5. , Y. C., Huang, D. Q., Nguyen, M. H. (2023) Global burden of hepatitis B virus: current status, missed opportunities and a call for action. Nat. Rev. Gastroenterol. Hepatol. 20, 524-537.
<https://doi.org/10.1038/s41575-023-00760-9>
6. , J. S., Lee, D., Hong, J. Y. (2024) Multi-layered mechanisms of immunological tolerance at the maternal-fetal interface. Immune Netw. 24, e30.
<https://doi.org/10.4110/in.2024.24.e30>
7. , G. A., Choi, S. W., Han, S. et al. (2024) Non-linear association between liver fibrosis scores and viral load in patients with chronic hepatitis B. Clin. Mol. Hepatol. 30, 793-806.
<https://doi.org/10.3350/cmh.2024.0252>
8. , Q. Y., An, Z. Y., Li, C. et al. (2021) Chronic active hepatitis B with COVID-19 in pregnancy: a case report. J. Clin. Transl. Hepatol. 9, 133-135.
9. , W. Y., Kong, C. W., To, W. W. K. (2021) Prevalence of hepatitis B carrier status and its negative association with hypertensive disorders in pregnancy. Obstet. Gynecol. Int. 2021, 9912743.
<https://doi.org/10.1155/2021/9912743>
10. , H., Cao, W., Zhang, L. et al. (2023) Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity. Front. Immunol. 14, 1122048.
<https://doi.org/10.3389/fimmu.2023.1122048>
11. , W., Wang, Y., Liu, J. (2025) NLRP3 inflammasome activation in liver disorders: from molecular pathways to therapeutic strategies. J. Inflamm. Res. 18, 8277-8294.
<https://doi.org/10.2147/JIR.S532908>
12. , M. L., Romao-Veiga, M., Ribeiro, V. R. et al. (2021) Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia. J. Reprod. Immunol. 144, 103286.
<https://doi.org/10.1016/j.jri.2021.103286>
13. , E., Mezzasoma, L., Bellezza, I. et al. (2023) Microbiota-associated HAF-EVs regulate monocytes by triggering or inhibiting inflammasome activation. Int. J. Mol. Sci. 24, 2527.
<https://doi.org/10.3390/ijms24032527>
14. , H. A., Abuhamdah, S. M. A., Hassan, M. H. et al. (2024) NLRP3 inflammasome pathway involved in the pathogenesis of metabolic associated fatty liver disease. Sci. Rep. 14, 19648.
<https://doi.org/10.1038/s41598-024-69764-y>
15. , O., Lamkanfi, M. (2022) The human inflammasomes. Mol. Aspects Med. 88, 101100.
<https://doi.org/10.1016/j.mam.2022.101100>
16. , R. K., Thakur, V., Arya, S. et al. (2022) Placenta as a site of HEV replication and inflammatory cytokines modulating the immunopathogenesis of HEV in pregnant women. J. Med. Virol. 94, 3457-3463.
<https://doi.org/10.1002/jmv.27699>
17. , K., Battistella, S., Russo, F. P. (2024) NLRP3 inflammasome in acute and chronic liver diseases. Int. J. Mol. Sci. 25, 4537.
<https://doi.org/10.3390/ijms25084537>
18. , Q., Hu, T., Xu, L. et al. (2025) Fingolimod suppresses NLRP3 inflammasome activation and alleviates oxidative stress in traumatic brain injury-induced acute lung injury. J. Inflamm. Res. 18, 2229-2245.
<https://doi.org/10.2147/JIR.S503428>
19. , Q., Wang, C. R., Li, H. et al. (2025) Higher risk of postpartum phase transition to immune-active among HBeAg-positive pregnant women with indeterminate phase. Front. Cell Infect. Microbiol. 15, 1652690.
<https://doi.org/10.3389/fcimb.2025.1652690>
20. , S. G., Lelievre, R. M., Westerveld, M. J. et al. (2022) Viral-mediated activation and inhibition of programmed cell death. PLoS Pathog. 18, e1010718.
<https://doi.org/10.1371/journal.ppat.1010718>
21. , P., Yang, G., Cheng, Q. et al. (2024) The role of inflammasome in chronic viral hepatitis. Front. Cell Infect. Microbiol. 14, 1382029.
<https://doi.org/10.3389/fcimb.2024.1382029>
22. , L., Wang, J., Zhao, K. et al. (2024) The relationship between viral replication and the severity of hepatic necroinflammatory damage changed before HBeAg loss in patients with chronic hepatitis B virus infection. J. Clin. Transl. Hepatol. 12, 381-388.
<https://doi.org/10.14218/JCTH.2023.00378>
23. , M., Wang, J., Yin, J. et al. (2023) Effects of HBsAg carriers on pregnancy complications in pregnant women: a retrospective cohort study. Front. Med. (Lausanne) 10, 1166530.
<https://doi.org/10.3389/fmed.2023.1166530>
24. , S., Zeng, N., Sun, F. et al. (2021) Hepatocellular carcinoma prediction models in chronic hepatitis B: a systematic review of 14 models and external validation. Clin. Gastroenterol. Hepatol. 19, 2499-2513.
<https://doi.org/10.1016/j.cgh.2021.02.040>
25. , W. H., Ding, J., Xie, X. X. et al. (2020) Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation. Inflamm. Res. 69, 683-696.
<https://doi.org/10.1007/s00011-020-01351-z>
26. , D., Wang, S., Cheng, N. et al. (2025) Exploring the combined impact of hepatitis B antibody status and systemic immune-inflammation index on mortality risk: a population-based study. PLoS One 20, e0328400.
<https://doi.org/10.1371/journal.pone.0328400>
27. , H., Luo, Y., Chen, X. et al. (2025) TAGLN2 exacerbates acute pancreatitis-induced liver injury by increasing hepatocyte pyroptosis via Kupffer cells-mediated inflammatory response. Arch. Immunol. Ther. Exp. (Warsz.) 73.
