Fol. Biol. 2026, 72, 95-108
https://doi.org/10.14712/fb2026.0010
Intravitreal Application of Mesenchymal Stem Cell By-Products Does Not Ameliorate Experimental Autoimmune Uveitis
References
1. , P., Mills, S. J., Cowin, A. J. (2020) Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Int. J. Mol. Sci. 21, 7038.
<https://doi.org/10.3390/ijms21197038>
2. , L., Shao, H., Wang, H. et al. (2017) Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis. Sci. Rep. 7, 4323.
<https://doi.org/10.1038/s41598-017-04559-y>
3. , M. A., Sendon-Lago, J., Seoane, S. et al. (2016) Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis. Exp. Eye Res. 149, 84-92.
<https://doi.org/10.1016/j.exer.2016.06.022>
4. , R. R., Roberge, F. G., Chan, C. C. et al. (1988) A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J. Immunol. 140, 1490-1495.
<https://doi.org/10.4049/jimmunol.140.5.1490>
5. , M., Le Blanc, K., Mueller, I. et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317.
<https://doi.org/10.1080/14653240600855905>
6. , J. C., Poston, J. N., Balyasnikova, I. et al. (2014) Delayed administration of bone marrow mesenchymal stem cell conditioned medium significantly improves outcome after retinal ischemia in rats. Invest. Ophthalmol. Vis. Sci. 55, 3785-3796.
<https://doi.org/10.1167/iovs.13-11683>
7. , Y., Chen, X., Shao, H. et al. (2024) Enhanced immunosuppressive capability of mesenchymal stem cell-derived small extracellular vesicles with high expression of CD73 in experimental autoimmune uveitis. Stem Cell Res. Ther. 15, 149.
<https://doi.org/10.1186/s13287-024-03764-7>
8. , O., Fajstova, A., Klimova, A. et al. (2020) Severity of experimental autoimmune uveitis is reduced by pretreatment with live probiotic Escherichia coli Nissle 1917. Cells 10, 23.
<https://doi.org/10.3390/cells10010023>
9. , J., Seidler Stangova, P., Klimova, A. et al. (2016) The microbiota determines susceptibility to experimental autoimmune uveoretinitis. J. Immunol. Res. 2016, 5065703.
<https://doi.org/10.1155/2016/5065703>
10. , B., Kossl, J., Bohacova, P. et al. (2019) The immunomodulatory potential of mesenchymal stem cells in a retinal inflammatory environment. Stem Cell Rev. Rep. 15, 880-891.
<https://doi.org/10.1007/s12015-019-09908-0>
11. , B., Kossl, J., Javorkova, E. et al. (2017) The identification of interferon-γ as a key supportive factor for retinal differentiation of murine mesenchymal stem cells. Stem Cells Dev. 26, 1399-1408.
<https://doi.org/10.1089/scd.2017.0111>
12. , V., Palacka, K., Hermankova, B. (2021) Mesenchymal stem cell-based therapy for retinal degenerative diseases: experimental models and clinical trials. Cells 10, 588.
<https://doi.org/10.3390/cells10030588>
13. , K. A., Lobo-Chan, A. M. (2021) Epidemiology and risk factors in non-infectious uveitis: a systematic review. Front. Med. (Lausanne) 8, 695904.
<https://doi.org/10.3389/fmed.2021.695904>
14. , M., Choi, J. K., Jittayasothorn, Y. et al. (2020) Interleukin 35-producing exosomes suppress neuroinflammation and autoimmune uveitis. Front. Immunol. 11, 1051.
<https://doi.org/10.3389/fimmu.2020.01051>
15. , A., Shen, W. Y., Wilson, A. S. et al. (2003) Differentiation of marrow stromal cells into photoreceptors in the rat eye. J. Neurosci. 23, 7742-7749.
<https://doi.org/10.1523/JNEUROSCI.23-21-07742.2003>
16. , A., Seidler Stangova, P., Svozilkova, P. et al. (2016) The critical points in induction of experimental autoimmune uveitis. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 160, 140-142.
<https://doi.org/10.5507/bp.2015.056>
17. , A. M., Zarbin, M. A. (2014) Trophic factors in the pathogenesis and therapy for retinal degenerative diseases. Surv. Ophthalmol. 59, 134-165.
<https://doi.org/10.1016/j.survophthal.2013.09.004>
18. , A. E., Albini, T. A., Townsend, J. H. et al. (2017) Vision loss after intravitreal injection of autologous “stem cells” for AMD. N. Engl. J. Med. 376, 1047-1053.
<https://doi.org/10.1056/NEJMoa1609583>
19. , G., Yuan, L., Ren, X. et al. (2013) The effect of mesenchymal stem cells on dynamic changes of T cell subsets in experimental autoimmune uveoretinitis. Clin. Exp. Immunol. 173, 28-37.
<https://doi.org/10.1111/cei.12080>
20. , Y., Ren, X., Zhang, Z. et al. (2022) Effect of small extracellular vesicles derived from IL-10-overexpressing mesenchymal stem cells on experimental autoimmune uveitis. Stem Cell Res. Ther. 13, 100.
<https://doi.org/10.1186/s13287-022-02780-9>
21. , H., Ong, H. S., Riau, A. K. et al. (2019) Current trends and future perspective of mesenchymal stem cells and exosomes in corneal diseases. Int. J. Mol. Sci. 20, 2853.
<https://doi.org/10.3390/ijms20122853>
22. , B., Poston, J. N., Dreixler, J. C. et al. (2017) Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats. Graefes Arch. Clin. Exp. Ophthalmol. 255, 1581-1592.
<https://doi.org/10.1007/s00417-017-3690-1>
23. , M., Jayawardena, T. M., Schmeckpeper, J. et al. (2011) Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J. Mol. Cell. Cardiol. 50, 280-289.
<https://doi.org/10.1016/j.yjmcc.2010.08.005>
24. , E., Anderson, J. D., Oltjen, S. et al. (2017) Protective effect of intravitreal administration of exosomes derived from mesenchymal stem cells on retinal ischemia. Curr. Eye Res. 42, 1358-1367.
<https://doi.org/10.1080/02713683.2017.1319491>
25. , M., Guyomard, J. L., Simonutti, M. et al. (2007) Panretinal, high-resolution color photography of the mouse fundus. Invest. Ophthalmol. Vis. Sci. 48, 2769-2774.
<https://doi.org/10.1167/iovs.06-1099>
26. , S. S., Moisseiev, E., Bauer, G. et al. (2017) Advances in bone marrow stem cell therapy for retinal dysfunction. Prog. Retin. Eye Res. 56, 148-165.
<https://doi.org/10.1016/j.preteyeres.2016.10.002>
27. , Y., Chan, A. M., Chang, Y. L. et al. (2018) Human embryonic stem cell-derived mesenchymal stromal cells decrease the development of severe experimental autoimmune uveitis in B10.RIII mice. Ocul. Immunol. Inflamm. 26, 1228-1236.
<https://doi.org/10.1080/09273948.2017.1343356>
28. , G., Ramadan, A., Abburi, C. et al. (2014) Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS One 9, e84671.
<https://doi.org/10.1371/journal.pone.0084671>
29. , J. T., Bodaghi, B., Couto, C. et al. (2019) New observations and emerging ideas in diagnosis and management of non-infectious uveitis: a review. Semin. Arthritis Rheum. 49, 438-445.
<https://doi.org/10.1016/j.semarthrit.2019.06.004>
30. , P., Dusek, O., Klimova, A. et al. (2019) Metronidazole attenuates the intensity of inflammation in experimental autoimmune uveitis. Folia Biol. (Praha) 65, 265-274.
<https://doi.org/10.14712/fb2019065050265>
31. , T., Oh, J. Y., Kim, D. K. et al. (2017) MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis. Stem Cell Reports 8, 1214-1225.
<https://doi.org/10.1016/j.stemcr.2017.04.008>
32. , R., Ilengo, C., Quarto, R. et al. (2012) Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 53, 786-793.
<https://doi.org/10.1167/iovs.11-8211>
33. , T., Dastiridou, A., Symeonidis, C. et al. (2018) A focus on the epidemiology of uveitis. Ocul. Immunol. Inflamm. 26, 2-16.
<https://doi.org/10.1080/09273948.2016.1196713>
34. , J. H., Liu, X. L., Sun, J. M. et al. (2020) Role of mesenchymal stem cell derived extracellular vesicles in autoimmunity: a systematic review. World J. Stem Cells 12, 879-896.
<https://doi.org/10.4252/wjsc.v12.i8.879>
35. , H., Koch, P., Chen, M. et al. (2008) A clinical grading system for retinal inflammation in the chronic model of experimental autoimmune uveoretinitis using digital fundus images. Exp. Eye Res. 87, 319-326.
<https://doi.org/10.1016/j.exer.2008.06.012>
36. , B., Shao, H., Su, C. et al. (2016) Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1. Sci. Rep. 6, 34562.
<https://doi.org/10.1038/srep34562>
37. , B., Zhang, X., Li, X. (2014) Exosomes derived from mesenchymal stem cells. Int. J. Mol. Sci. 15, 4142-4157.
<https://doi.org/10.3390/ijms15034142>
38. , P. T., Zhang, L. J., Shao, H. et al. (2016) Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. Int. J. Ophthalmol. 9, 1381-1389.

