Correlation Between circ_0092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary Heart Disease and Its Clinical Value

Dai, Wenqin; Wang, Lingli; Li, Yuan; Liu, Li; Chen, Peng

doi:10.14712/fb2026.0011

Fol. Biol., Online First article

https://doi.org/10.14712/fb2026.0011

Correlation Between circ_0092576 and Arterial Stenosis Severity and Inflammatory Status in Patients with Coronary Heart Disease and Its Clinical Value

Wenqin Dai¹

, Lingli Wang², Yuan Li³

, Li Liu³

, Peng Chen⁴

¹Department of Cardiology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430063, Hubei, China
²Department of Cardiology, Shanghai 8th People’s Hospital, Shanghai, China
³Department of General Practice, Chinese and Western Medicine Hospital of Panzhihua, Panzhihua, Sichuan, China
⁴Department of Interventional Medicine, People’s Hospital of Jiulongpo District, Chongqing, 400050, China

Received November 6, 2025
Accepted March 17, 2026

This study aims to investigate the predictive value of circ_0092576 for coronary heart disease (CHD) and major adverse cardiac events (MACE) risk, and to elucidate its association with the degree of coronary artery stenosis and inflammatory status. A total of 200 CHD patients and 180 non-CHD controls were recruited. Plasma levels of circ_0092576, IL-1β, TNF-α and IL-10 were measured using RT-qPCR. Coronary artery stenosis severity was assessed using the Gensini score system, and MACE occurrence was recorded during regular follow-up. circ_0092576 levels were significantly higher in CHD patients than in the control group, with an area under the ROC curve (AUC) of 0.885. Furthermore, circ_0092576 showed significant positive correlations with Gensini scores and pro-inflammatory factors IL-1β and TNF-α while exhibiting a negative correlation with the anti-inflammatory factor IL-10. Follow-up revealed significantly elevated circ_0092576 levels in patients who developed MACE. Compared to the low circ_0092576 group, the high circ_0092576 group exhibited a significantly higher cumulative incidence of MACE. Elevated circ_0092576 levels correlate with increased risk of CHD and subsequent MACE. In summary, circ_0092576 is a potential biomarker for CHD risk and prognosis. Elevated levels indicate increased risk of CHD, more severe coronary artery stenosis, stronger inflammation, and are associated with an increased risk of adverse cardiac events.