Fol. Biol. 2000, 46, 25-29
SHR.BN-Congenic Strains for Genetic Analysis of Multifactorially Determined Traits
The laboratory rat is an important laboratory animal with multiple well-defined inbred strains, including some of the most widely used animal models of human diseases. Recent advances in the development of rat genetic resources will enable the exploitation of the full potential of rat models of human diseases and, in addition, the rat can provide useful information for comparative genomics of humans and mice. In the current review, we describe the development of congenics strains by introgression of differential chromosome segments from the Brown Norway (BN) rat to the genetic background of the spontaneously hypertensive rat (SHR). These SHR.BN-congenic strains and recombinant sublines derived from them were developed as a model system for genetic analysis of multifactorially determined pathophysiological and morphological conditions.
Funding
This work was supported by grants 306/97/0521 and 204/98/K015 from the Grant Agency of the Czech Republic and by the grant 96005 from the US-CZ Science and Technology Program. M. Pravenec is an International Research Scholar of the Howard Hughes Medical Institute.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.