Genomic Organization of the Mouse <i>src</i> Gene. Sequencing of <i>src</i> Introns Revealed a New Chromosome 2 Microsatellite Marker

Fučík, Vladimír; Beran, J.; Černý, Z.; Mácha, J.; Jonák, J.

doi:10.14712/fb2002048010034

Fol. Biol. 2002, 48, 34-39

https://doi.org/10.14712/fb2002048010034

Genomic Organization of the Mouse src Gene. Sequencing of src Introns Revealed a New Chromosome 2 Microsatellite Marker

Vladimír Fučík¹, J. Beran¹, Z. Černý¹, J. Mácha², J. Jonák¹

¹Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
²Faculty of Science, Charles University, Prague, Czech Republic

Received August 2001
Accepted November 2001

Ten introns interrupting the coding sequence of the mouse src protooncogene were sequenced (in total 11260 bp) and their general characteristics compared with the homologous genes in human and chicken. While the study of genome organization of the src gene was performed only in the inbred mouse strain BALB/cHeA (Mus musculus domesticus), one special region in the intron 5 was also sequenced in additional mouse strains (M. musculus musculus and M. spretus), because the discovered CA and GT repeat array differences could serve as a new polymorphic marker in the chromosome No. 2 and help elucidate some evolutionary relations between mouse strains.