Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2002, 48, 213-226

https://doi.org/10.14712/fb2002048060213

Relevant Animal Model of Human Lymphoblastic Leukaemia/Lymphoma Spontaneous T-Cell Lymphomas in an Inbred Sprague-Dawley Rat Strain (SD/Cub)

Berta Otová1, M. Sladká1, J. Damoiseaux2, A. Panczak1, V. Mandys3,4, I. Marinov5

1Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
2Department of Experimental and Clinical Immunology, University Maastricht, Maastricht, The Netherlands
3Department of Pathology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
4Department of Teratology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
5Institute of Haematology and Blood Transfusion, Clinical Department, Prague, Czech Republic

Received June 2002
Accepted July 2002

More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory.

Funding

This work was supported by the Grant of the Ministry of Education, Youth and Sports of the Czech Republic CEZ J13/98:111100004.

References

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