Fol. Biol. 2002, 48, 213-226
Relevant Animal Model of Human Lymphoblastic Leukaemia/Lymphoma Spontaneous T-Cell Lymphomas in an Inbred Sprague-Dawley Rat Strain (SD/Cub)
More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory.
Keywords
T-cell, lymphoma, leukaemia, rat model, immunophenotype, cytogenetics, cell cycle, immunochemistry, experimental therapy.
Funding
This work was supported by the Grant of the Ministry of Education, Youth and Sports of the Czech Republic CEZ J13/98:111100004.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.