Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2003, 49, 63-68

https://doi.org/10.14712/fb2003049020063

Pretreatment with Interleukin-2 Modulates Perioperative Immunodysfunction in Patients with Renal Cell Carcinoma

Malte Böhm1, A. Ittenson2, T. Klatte1, K. F. Schierbaum1, F.-W. Röhl3, S. Ansorge2, E. P. Allhoff1

1Department of Urology, Otto-von-Guericke-University, Magdeburg, Germany
2Institute of Experimental Internal Medicine, Otto-von-Guericke-University, Magdeburg, Germany
3Institute of Biometrics and Medical Informatics, Otto-von-Guericke-University, Magdeburg, Germany

Received January 2003
Accepted February 2003

References

1. Allendorf, J. D., Bessler, M., Whelan, R. L., Trokel, M., Laird, D. A., Terry, M. B., Treat, M. R. (1997) Postoperative immune function varies inversely with the degree of surgical trauma in a murine model. Surg. Endosc. 11, 427-430. <https://doi.org/10.1007/s004649900383>
2. American Cancer Society (2000) American Cancer Society's Guide to Complementary and Alternative Cancer Methods. American Cancer Society, Atlanta.
3. Ashida, S., Okuda, H., Chikazawa, M., Tanimura, M., Sugita, O., Yamamoto, Y., Nakamura, S., Moriyama, M., Shuin, T. (2000) Detection of circulating cancer cells with von Hippel-Lindau gene mutation in peripheral blood of patients with renal cell carcinoma. Clin. Cancer. Res. 6, 3817-3822.
4. Biffl, W. L., Moore, E. E., Moore, F. A., Peterson, V. M. (1996) Interleukin-6 in the injured patient - marker of injury or mediator of inflammation? Ann. Surg. 224, 647-664. <https://doi.org/10.1097/00000658-199611000-00009>
5. Bilkenroth, U., Taubert, H., Riemann, D., Rebmann, U., Heynemann, H., Meye, A. (2001) Detection and enrichment of disseminated renal carcinoma cells from peripheral blood by immunomagnetic cell separation. Int. J. Cancer 92, 577-582. <https://doi.org/10.1002/ijc.1217>
6. Bovo, G., Brivio, F., Brenna, A., Fumagalli, L., Perego, P., Brivio, O., Uggeri, F., Lavorato, F., Bratina, G. (1995) Preoperative interleukin-2 immunotherapy induces eosinophilic infiltration in colorectal neoplastic stroma. Pathologica 87, 135-138.
7. Böhm, M., Ittenson, A., Philipp, C., Röhl, F.-W., Ansorge, S., Allhoff, E. P. (2001) Complex perioperative immunodysfunction in patients with renal cell carcinoma. J. Urol. 166, 831-836. <https://doi.org/10.1016/S0022-5347(05)65846-6>
8. Böhm, M., Ittenson, A., Schierbaum, K. F., Röhl, F.-W., Ansorge, S., Allhoff, E. P. (2002) Pretreatment with interleukin-2 (IL-2) attenuates perioperative immunodysfunction in patients with renal cell carcinoma. Eur. Urol. 41, 458-468. <https://doi.org/10.1016/S0302-2838(02)00031-3>
9. Brivio, F., Brivio, O., Lissoni, P., Emanuelli, G., Girlando, M., Uggeri, F. (1997) Presurgical neuroimmunotherapy with melatonin and interleukin-2 in cancer patients. In: Therapeutic Potential of Melatonin. Front. Horm. Res., eds. Maestroni, G. J. M., Conti, A., Reiter, R. J., pp. 137-148, Karger, Basel.
10. Brivio, F., Lissoni, P., Alderi, G., Barni, S., Lavorato, F., Fumagalli, L. (1996) Preoperative interleukin-2 subcutaneous immunotherapy may prolong the survival time in advanced colorectal cancer patients. Oncology 53, 263-268. <https://doi.org/10.1159/000227571>
11. Brivio, F., Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Erba, L., Alderi, G., Nociti, V. (1993) Effects of a preoperative course of interleukin-2 on surgical and immunobiological variables in patients with colorectal cancer: a phase 2 study. Eur. J. Surg. 159, 43-47.
12. Brivio, F., Lissoni, P., Tisi, E., Erba, L., Barni, S., Tancini, G., Rescaldani, R., Alderi, G., Nociti, V. (1992) Effects of a preoperative therapy with interleukin-2 on surgeryinduced lymphocytopenia in cancer patients. Oncology 49, 215-218. <https://doi.org/10.1159/000227041>
13. Brix-Christensen, V., Tønnesen, E., Sørensen, I. J., Bilfinger, T. V., Sanchez, R. G., Stefano, G. B. (1998) Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery. Acta Anaesthesiol. Scand. 42, 63-70. <https://doi.org/10.1111/j.1399-6576.1998.tb05082.x>
14. Danielpour, D. (1993) Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor fl1. J. Immunol. Methods 158, 17-25. <https://doi.org/10.1016/0022-1759(93)90254-5>
15. Deehan, D. J., Heys, S. D., Simpson, W., Broom, J., McMillan, D. N., Eremin, O. (1995) Modulation of the cytokine and acute-phase response to major surgery by recombinant interleukin-2. Br. J. Surg. 82, 86-90. <https://doi.org/10.1002/bjs.1800820130>
16. Fair, W. R. (1999) Back to the future - the role of complementary medicine in urology. J. Urol. 162, 411-420. <https://doi.org/10.1016/S0022-5347(05)68573-4>
17. Fornara, P., Doehn, C., Seyfarth, M., Jocham, D. (2000) Why is urological laparoscopy minimally invasive? Eur. Urol. 37, 241-250. <https://doi.org/10.1159/000052351>
18. Gilliland, H. E., Armstrong, M. A., Carabine, U., McMurray, T. J. (1997) The choice of anesthetic maintenance technique influences the antiinflammatory cytokine response to abdominal surgery. Anesth. Analg. 85, 1394-1398. <https://doi.org/10.1213/00000539-199712000-00039>
19. Gitzelmann, C. A., Mendoza-Sagaon, M., Talamini, M. A., Ahmad, S. A., Pegoli, W. J., Paidas, C. N. (2000) Cellmediated immune response is better preserved by laparoscopy than laparotomy. Surgery 127, 65-71. <https://doi.org/10.1067/msy.2000.101152>
20. Giuliani, L., Giberti, C., Martorana, G., Rovida, S. (1990) Radical extensive surgery for renal cell carcinoma: longterm results and prognostic factors. J. Urol. 143, 468-474. <https://doi.org/10.1016/S0022-5347(17)39992-5>
21. Heiss, M. M., Fraunberger, P., Delanoff, C., Stets, R., Allgayer, H., Strohlein, M. A., Tarabichi, A., Faist, E., Jauch, K. W., Schildberg, F. W. (1997) Modulation of immune response by blood transfusion: evidence for a differential effect of allogeneic and autologous blood in colorectal cancer surgery. Shock 8, 402-408. <https://doi.org/10.1097/00024382-199712000-00002>
22. Hensler, T., Hecker, H., Heeg, K., Heidecke, C.-D., Bartels, H., Barthlen, W., Wagner, H., Siewert, J. R., Holzmann, B. (1997) Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect. Immun. 65, 2283-2291. <https://doi.org/10.1128/iai.65.6.2283-2291.1997>
23. Herrlinger, A., Schrott, K. M., Schott, G., Sigel, A. (1991) What are the benefits of extended dissection of the regional lymph nodes in the therapy of renal cell carcinoma? J. Urol. 146, 1224-1227. <https://doi.org/10.1016/S0022-5347(17)38052-7>
24. Hisano, S., Sakamoto, K., Ishiko, T., Kamohara, H., Ogawa, M. (1997) IL-6 and soluble IL-6 receptor levels change differently after surgery both in the blood and in the operative field. Cytokine 9, 447-447. <https://doi.org/10.1006/cyto.1996.0187>
25. Hultén, L., Rosencrantz, M., Seeman, T., Wahlqvist, L., Åhrén, C. (1969) Occurrence and localization of lymph node metastases in renal carcinoma. Scand. J. Urol. Nephrol. 3, 129-133. <https://doi.org/10.3109/00365596909135393>
26. Hunter, J. D. (1999) Effects of anaesthesia on the human immune system. Hosp. Med. 60, 658-663. <https://doi.org/10.12968/hosp.1999.60.9.1198>
27. Ishijima, N., Suzuki, H. (1998) Blood transfusion and post-operative serum interleukin-6 levels in colorectal cancer patients. Hepatogastroenterology 45, 1011-1013.
28. Kato, M., Honda, I., Suzuki, H., Murakami, M., Matsukawa, S., Hashimoto, Y. (1998) Interleukin-10 production during and after upper abdominal surgery. J. Clin. Anesth. 10, 184-188. <https://doi.org/10.1016/S0952-8180(97)00264-X>
29. Koo, A. S., Armstrong, C., Bochner, B., Shimabukuro, T., Tso, C.-L., DeKernion, J. B., Belldegrun, A. (1992) Interleukin-6 and renal cell cancer: production, regulation, and growth effects. Cancer Immunol. Immunother. 35, 97-105. <https://doi.org/10.1007/BF01741856>
30. Kuntz, C., Wunsch, A., Bay, F., Windeler, J., Glaser, F., Herfarth, C. (1998) Prospective randomized study of stress and immune response after laparoscopic vs conventional colonic resection. Surg. Endosc. 12, 963-967. <https://doi.org/10.1007/s004649900757>
31. Leaver, H. A., Craig, S. R., Yap, P. L., Walker, W. S. (2000) Lymphocyte responses following open and minimally invasive thoracic surgery. Eur. J. Clin. Invest. 30, 230-238. <https://doi.org/10.1046/j.1365-2362.2000.00622.x>
32. Lodge, P., Jones, L., Bader, R., Murphy, G., Salgaller, M. (2000) Dendritic cell-based immunotherapy of prostate cancer: immune monitoring of a phase II clinical trial. Cancer Res. 60, 829-833.
33. Masotti, A., Morandini, G., Ortolani, R., Fumagalli, L. (1998) Phase-II randomized study of pre-operative IL-2 administration in operable NSCLC. Lung Cancer 20, 191-202. <https://doi.org/10.1016/S0169-5002(98)00024-5>
34. McKiernan, J. M., Buttyan, R., Bander, N. H., de la Taille, A., Stifelman, M. D., Emanuel, E. R., Bagiella, E., Rubin, M. A., Katz, A. E., Olsson, C. A., Sawczuk, I. S. (1999) The detection of renal carcinoma cells in the peripheral blood with an enhanced reverse transcriptase-polymerase chain reaction assay for MN/CA9. Cancer 86, 492-497. <https://doi.org/10.1002/(SICI)1097-0142(19990801)86:3<492::AID-CNCR18>3.0.CO;2-R>
35. Miki, S., Iwano, M., Miki, Y., Yamamoto, M., Tang, B., Yokokawa, K., Sonoda, T., Hirano, T., Kishimoto, T. (1989) Interleukin-6 (IL-6) functions as an autocrine growth factor in renal cell carcinomas. FEBS Lett. 250, 607-610. <https://doi.org/10.1016/0014-5793(89)80805-1>
36. Nichols, P. H., Ramsden, C. W., Ward, U., Sedman, P. C., Primrose, J. N. (1992) Perioperative immunotherapy with recombinant interleukin 2 in patients undergoing surgery for colorectal cancer. Cancer Res. 52, 5765-5769.
37. Nichols, P. H., Ramsden, C. W., Ward, U., Trejdosiewicz, L. K., Ambrose, N. S., Primrose, J. N. (1993) Peri-operative modulation of cellular immunity in patients with colorectal cancer. Clin. Exp. Immunol. 94, 4-10. <https://doi.org/10.1111/j.1365-2249.1993.tb05968.x>
38. Ogawa, K., Hirai, M., Katsube, T., Murayama, M., Hamaguchi, K., Shimakawa, T., Naritake, Y., Hosokawa, T., Kajiwara, T. (2000) Suppression of cellular immunity by surgical stress. Surgery 127, 329-336. <https://doi.org/10.1067/msy.2000.103498>
39. Parry-Billings, M., Baigrie, R. J., Lamont, P. M., Morris, P. J., Newsholme, E. A. (1992) Effects of major and minor surgery on plasma glutamine and cytokine levels. Arch. Surg. 127, 1237-1240. <https://doi.org/10.1001/archsurg.1992.01420100099017>
40. Roncarolo, M.-G., Levings, M. K. (2000) The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12, 676-683. <https://doi.org/10.1016/S0952-7915(00)00162-X>
41. Roncarolo, M.-G., Levings, M. K., Traversari, C. (2001) Differentiation of T regulatory cells by immature dendritic cells. J. Exp. Med. 193, F5-F9. <https://doi.org/10.1084/jem.193.2.F5>
42. SAS Institute Inc. (1994) SAS/STAT User's Guide, Version 6; SAS Institute, Cary, North Carolina.
43. Sánchez de la Muela, P., Zudaire, J. J., Robles, J. E., Rosell, D., Aguera, L., De Castro, F., Isa, W., Berián, J. M. (1991) Renal cell carcinoma: vena caval invasion and prognostic factors. Eur. Urol. 19, 284-290. <https://doi.org/10.1159/000473644>
44. Sheeran, P., Hall, G. M. (1997) Cytokines in anaesthesia. Br. J. Anaesth. 78, 201-219. <https://doi.org/10.1093/bja/78.2.201>
45. Song, G. Y., Chung, C.-S., Chaudry, I. H., Ayala, A. (1999) What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant? Surgery 126, 378-383. <https://doi.org/10.1016/S0039-6060(99)70180-7>
46. Southall, J. C., Lee, S. W., Bessler, M., Allendorf, J. D., Whelan, R. L. (1998) The effect of peritoneal air exposure on postoperative tumour growth. Surg. Endosc. 12, 348-350. <https://doi.org/10.1007/s004649900668>
47. Stanojevic-Bakic, N., Vuckovic-Dekic, L., Radomirovic, S., Juranic, Z., Jovanovic, N. (1999) The influence of surgery and anesthesia on lymphocyte functions in breast cancer patients: in vitro effects of indomethacin. Neoplasma 46, 54-60.
48. Steinhauser, M. L., Hogaboam, C. M., Kunkel, S. L., Lukacs, N. W., Strieter, R. M., Standiford, T. J. (1999) IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. J. Immunol. 162, 392-399. <https://doi.org/10.4049/jimmunol.162.1.392>
49. Takenawa, J., Kaneko, Y., Fukumoto, M., Fukatsu, A., Hirano, T., Fukuyama, H., Nakayama, H., Fujita, J., Yoshida, O. (1991) Enhanced expression of interleukin-6 in primary human renal cell carcinomas. J. Natl. Cancer Inst. 83, 1668-1672. <https://doi.org/10.1093/jnci/83.22.1668>
50. Takenawa, J., Kaneko, Y., Okumura, K., Yoshida, O., Nakayama, H., Fujita, J. (1995) Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal cell carcinomas and effects on expression of interleukin-6 or interleukin-6 receptor. J. Urol. 153, 858-862. <https://doi.org/10.1016/S0022-5347(01)67736-X>
51. Ulchaker, J. C., Klein, E. A. (1996) Biology of metastasis and its clinical implications: renal-cell cancer. World J. Urol. 14, 175-181. <https://doi.org/10.1007/BF00186897>
52. World Health Organization (1979) WHO Handbook for Reporting Results of Cancer Treatment, World Health Organization, Geneva.
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