Fol. Biol. 2003, 49, 118-127
Functional Consequences of the Glycophenotype of Squamous Epithelia - Practical Employment
Squamous epithelia represent a morphologically and differentiation-dependent stratified tissue. The stem cells are located in the bulge region of hair follicles or in the basal layer of interfollicular epidermis and in the limbus of the cornea. This article summarizes the data about the glycobiological aspects of squamous epithelia cell differentiation under physiological as well as pathological conditions in relation to the function of this epithelial tissue. The entries about the LC, Merkel cells and melanocytes are also mentioned. The employment of the described data in the diagnostics of carcinomas derived from this type of epithelium as well as in the cell therapy of skin defects are shown.
Funding
The part of results summarized in this review was received in projects supported by the Ministry of Education, Youth and Sport of the Czech Republic Nos. MSM 111100005 and LN0A0065, the Ministry of Health of the Czech Republic No. ND 6340-3, the Grant Agency of the Czech Republic No. 203/00/1310 and No. 304/02/0463, and the Academy of Sciences of the Czech Republic No. S4050005.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.