Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2003, 49, 129-141

https://doi.org/10.14712/fb2003049040129

Selected Genetic Aspects of Male Infertility - What Animal Models Tell Us

František Liška

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic

Received May 2003
Accepted July 2003

Many advances have been recently made in understanding the genetic control of fertility in model systems. This review concentrates on genetic causes of male factor infertility in mammalian models. More than 150 genes proved to be important for the male fertility in mammals and the list is continuously growing. Most of those genes were discovered using gene targeting in the mouse. Here, several interesting male infertility mutations are described with regard to the pathogenesis of reproduction failure. A detailed table comprising most of the genes causing male infertility is presented as supplementary Table 1, at http://www.img.cas.cz/fb/v49no4_table1.html, including the corresponding references.

Funding

This work was supported by grant No. 301/02/0464 from the Grant Agency of the Czech Republic and by grant No. 36/2001/C from the Grant Agency of Charles University.

References

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