Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

Crossref logo

Fol. Biol. 2003, 49, 217-222

https://doi.org/10.14712/fb2003049060217

Adjuvant Cytokine Treatment of Minimal Residual Disease after Surgical Therapy in Mice Carrying HPV16-Associated Tumours: Cytolytic Activity of Spleen Cells from Tumour Regressors

Marie Indrová1, R. Mikyšková1, T. Jandlová1, V. Vonka2, J. Bubeník1, J. Bieblová1

1Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
2Institute of Haematology and Blood Transfusion, Prague, Czech Republic

Received October 2003
Accepted November 2003

References

1. Bubeník, J. (2002) Animal models for development of therapeutic HPV16 vaccines. Int. J. Oncol. 20, 207-212.
2. Bubeník, J. (2003) MHC class I downregulation and tumour immunotherapy. Oncol. Rep. 10, 2005-2008.
3. Bubeník, J., Lotzová, E., Indrová, M. Šímová, J., Jandlová, T., Bubeníková, D. (1992) Use of IL-2 gene transfer in local immunotherapy of cancer. Cancer Lett. 62, 257-262. <https://doi.org/10.1016/0304-3835(92)90104-4>
4. Bubeník, J., Zeuthen J., Indrová, M., Bubeníková, D., Šímová, J. (1994) Kinetics and function of peritoneal exudate cells during local IL-2 gene therapy of cancer. Int. J. Oncol. 4, 13-16.
5. Bubeník, J., Šímová, J., Hájková, R., Sobota, V., Jandlová, T., Šmahel, M., Sobotková. E., Vonka, V. (1999) Interleukin-2 gene therapy of residual disease in mice carrying tumours induced by HPV 16. Int. J. Oncol. 14, 593-597.
6. Bubeník, J., Mikyšková, R., Vonka, V., Mendoza, L., Šímová, J., Šmahel, M., Indrová, M. (2003) Interleukin 2 and dendritic cells as adjuvants for surgical therapy of tumours associated with human papilloma virus type 16. Vaccine 21, 890-896. <https://doi.org/10.1016/S0264-410X(02)00537-6>
7. Goldie, H., Butler, C. H., Anderson, M. M. (1953) Growth characteristic of free C1498 (granulocytic leukaemia) tumour cells in the peritoneal fluid and the blood of C57 mice. Cancer Res. 13, 125-129.
8. Indrová, M., Bubeník, J., Šímová, J., Bieblová, J., Jandlová, T., Šmahel, M., Vonka, V., Glazman-Kusnierczyk, H., Pajtasz-Piasecka, E., Radzikowski, C., Mikyšková, R. (2001) Chemoimmunotherapy of cancer: potentiated effectiveness of granulocyte-macrophage colony-stimulating factor and ifosfamide derivative CBM-4A. Oncol. Rep. 8, 1371-1374.
9. Indrová, M., Bubeník, J., Mikyšková, R., Vonka, V., Šmahel, M., Žák, R., Šímová, J., Bieblová, J., Mendoza, L., Jandlová, T. (2002) Tumour inhibitory and antimetastatic effect of IL-2 in mice carrying MHC class I tumours of HPV 16 origin. Int. J. Oncol. 20, 643-646.
10. Indrová, M., Bubeník, J., Mikyšková, R., Mendoza, L., Šímová, J., Bieblová, J., Jandlová, T., Jinoch, P., Šmahel, M., Vonka, V., Pajtasz-Piasecka, E. (2003) Chemoimmunotherapy in mice carrying HPV16-associated, MHC class I+ and class Iñ tumours: effects of CBM-4A potentiated with IL-2, IL-12, GM-CSF and genetically modified tumour vaccines. Int. J. Oncol. 22, 691-695.
11. Jinoch, P., Žák, R., Janoušková, O., Kunke, O., Ritich, S., Dušková, M., Sobotková, E., Marinov, I., Andělová, M., Šmahel, M., Vonka, V. (2003) Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine-kinase and either GM-CSF or IL-2. Int. J. Oncol. 23, 775-783.
12. LaBelle, J. L., Truit, R. L. (2002) Characterization of murine NKT cell tumor previously described as an acute myelogenous leukemia. Leuk. Lymphoma 43, 1637-1644. <https://doi.org/10.1080/1042819021000002974>
13. Lin, K. Y., Guarnieri, F. G., Staveley O'Carroll, K. F., Levitsky, H. J., August, J. T., Pardoll, D. M., Wu, T. C. (1996) Treatment of established tumours with a novel vaccine that enhances major histocompatibility class II presentation of tumour antigen. Cancer Res. 56, 21-26.
14. Mikyšková, R., Bubeník, J., Mendoza, L., Vonka, V., Šmahel, M., Šímová, J., Jandlová, T. (2001) Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases. Clin. Exp. Metastasis 18, 581-587. <https://doi.org/10.1023/A:1011987206008>
15. Mikyšková, R., Bieblová, J., Šímová, J., Indrová, M., Jandlová, T., Vonka, V., Šmahel, M., Bubeník, J., Mendoza, L. (2003a) Local IFNγ therapy of HPV16-associated tumours. Folia Biol. (Praha) 49, 26-32.
16. Mikyšková, R., Indrová, M. Šímová, J., Jandlová, T., Bieblová, J., Jinoch J., Bubeník, J., Vonka, V. (2003b) Treatment of minimal residual disease after surgery or chemotherapy in mice carrying HPV16-associated tumours: cytokine and gene therapy with IL-2 and GMCSF. Int. J. Oncol., in press.
17. Offringa, R., van der Burg, S. H., Ossendorp, F., Toes, R. E., Melief, C. J. (2000) Design and evaluation of antigen-specific vaccination strategies against cancer. Curr. Opin. Immunol. 12, 576-582. <https://doi.org/10.1016/S0952-7915(00)00145-X>
18. Šmahel, M., Sobotková, E., Bubeník, J., Šímová, J., Žák, R., Ludvíková, V., Hájková, R., Kovařík, J., Jelínek, F., Povýšil, C., Marinov, J., Vonka, V. (2001) Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16. Br. J. Cancer 84, 374-380. <https://doi.org/10.1054/bjoc.2000.1615>
19. Vlk, V., Rössner, P., Indrová, M., Bubeník, J., Sobota, V. (1998) Interleukin-2 gene therapy of surgical minimal residual tumour disease. Int. J. Cancer 76, 115-119. <https://doi.org/10.1002/(SICI)1097-0215(19980330)76:1<115::AID-IJC18>3.0.CO;2-B>
20. Wigzell, H., Ramstedt, U. (1986) Natural killer cells. In: Cellular Immunology, ed. Weir, M. M., pp. 601-609, Blackwell Scientific Publ., Oxford.
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive