Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2004, 50, 35-42

https://doi.org/10.14712/fb2004050020035

Non-immune Functions of MHC Class I Glycoproteins in Normal and Malignant Cells

D. Fishman, S. Elhyany, Shraga Segal

Department of Immunology and Microbiology, Faculty of Health Sciences, Ben-Gurion University Cancer Research Center, Ben-Gurion University of the Negev Beer-Sheva, Israel

References

1. Assa-Kunik, E., Fishman, D., Kellman-Pressman, S., Tsory, S., Elhyany, S., Baharir, O., Segal, S. (2003) Alterations in the expression of MHC class I glycoproteins by B16BL6 melanoma cells modulate insulin receptor-regulated signal transduction and augment [correction of augments] resistance to apoptosis. J. Immunol. 171, 2945-2952. <https://doi.org/10.4049/jimmunol.171.6.2945>
2. Bartosz, G., Szabo, G., Szollosi, J., Damjanovich, S. (1981) Aging of the erythrocyte. IX. Fluorescence studies on changes in membrane properties. Mech. Ageing Dev. 16, 265-274. <https://doi.org/10.1016/0047-6374(81)90102-0>
3. Bene, L., Balazs, M., Matko, J., Most, J., Dierich, M. P., Szollosi, J., Damjanovich, S. (1994) Lateral organization of the ICAM-1 molecule at the surface of human lymphoblasts: a possible model for its co-distribution with the IL-2 receptor, class I and class II HLA molecules. Eur. J. Immunol. 24, 2115-2123. <https://doi.org/10.1002/eji.1830240928>
4. Bian, H., Reed, E. F. (1999) Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: enhancement by IFN-gamma and TNF-alpha. J. Immunol. 163, 1010-1018. <https://doi.org/10.4049/jimmunol.163.2.1010>
5. Bian, H., Harris, P. E., Mulder, A., Reed, E. F. (1997) AntiHLA antibody ligation to HLA class I molecules expressed by endothelial cells stimulates tyrosine phosphorylation, inositol phosphate generation, and proliferation. Hum. Immunol. 53, 90-97. <https://doi.org/10.1016/S0198-8859(96)00272-8>
6. Bian, H., Harris, P. E., Reed, E. F. (1998) Ligation of HLA class I molecules on smooth muscle cells with anti-HLA antibodies induces tyrosine phosphorylation, fibroblast growth factor receptor expression and cell proliferation. Int. Immunol. 10, 1315-1323. <https://doi.org/10.1093/intimm/10.9.1315>
7. Calorini, L., Marozzi, A., Byers, H. R., Waneck, G. L., Lee, K. W., Isselbacher, K. J., Gattoni-Celli, S. (1992) Expression of a transfected H-2Kb gene in B16 cells correlates with suppression of liver metastases in triple immunodeficient mice. Cancer Res. 52, 4036-4041.
8. Caroni, P. (2001) New EMBO membersí review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts. EMBO J. 20, 4332-4336. <https://doi.org/10.1093/emboj/20.16.4332>
9. Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., Saltiel, A. R. (2001) Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410, 944-948. <https://doi.org/10.1038/35073608>
10. Chouaib, S., Asselin-Paturel, C., Mami-Chouaib, F., Caignard, A., Blay, J. Y. (1997) The host-tumour immune conflict: from immunosuppression to resistance and destruction. Immunol. Today 18, 493-497. <https://doi.org/10.1016/S0167-5699(97)01115-8>
11. Chvatchko, Y., Van Obberghen, E., Kiger, N., Fehlmann, M. (1983) Immunoprecipitation of insulin receptors by antibodies against Class 1 antigens of the murine H-2 major histocompatibility complex. FEBS Lett. 163, 207-211. <https://doi.org/10.1016/0014-5793(83)80820-5>
12. Corriveau, R. A., Huh, G. S., Shatz, C. J. (1998) Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron 21, 505-520. <https://doi.org/10.1016/S0896-6273(00)80562-0>
13. Cresswell, P., Bangia, N., Dick, T., Diedrich, G. (1999) The nature of the MHC class I peptide loading complex. Immunol. Rev. 172, 21-28. <https://doi.org/10.1111/j.1600-065X.1999.tb01353.x>
14. Damjanovich, S., Matko, J., Matyus, L., Szabo, G., Jr., Szollosi, J., Pieri, J. C., Farkas, T., Gaspar, R., Jr. (1998) Supramolecular receptor structures in the plasma membrane of lymphocytes revealed by flow cytometric energy transfer, scanning forceand transmission electron-microscopic analyses. Cytometry 33, 225-233. <https://doi.org/10.1002/(SICI)1097-0320(19981001)33:2<225::AID-CYTO18>3.0.CO;2-W>
15. Drake, D. R., 3rd, Braciale, T. J. (2001) Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells. J. Immunol. 166, 7009-7013. <https://doi.org/10.4049/jimmunol.166.12.7009>
16. Dricu, A., Kanter, L., Wang, M., Nilsson, G., Hjertman, M., Wejde, J., Larsson, O. (1999) Expression of the insulinlike growth factor 1 receptor (IGF-1R) in breast cancer cells: evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway. Glycobiology 9, 571-579. <https://doi.org/10.1093/glycob/9.6.571>
17. Due, C., Simonsen, M., Olsson, L. (1986) The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc. Natl. Acad. Sci. USA 83, 6007-6011. <https://doi.org/10.1073/pnas.83.16.6007>
18. Eyal, A., Levin, I., Segal, S., Levi, I., Klein, B., Kuperman, O. (1990) Variation of HLA-ABC surface antigen expression on adenocarcinoma of the colon in correlation with the degree of differentiation. Nat. Immun. Cell Growth Regul. 9, 222-227.
19. Fehlmann, M., Peyron, J. F., Samson, M., Van Obberghen, E., Brandenburg, D., Brossette, N. (1985) Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes. Proc. Natl. Acad. Sci. USA 82, 8634-8637. <https://doi.org/10.1073/pnas.82.24.8634>
20. Fishman, D., Irena, B., Kellman-Pressman, S., Karas, M., Segal, S. (2001) The role of MHC class I glycoproteins in the regulation of induction of cell death in immunocytes by malignant melanoma cells. Proc. Natl. Acad. Sci. USA 98, 1740-1744. <https://doi.org/10.1073/pnas.98.4.1740>
21. Garcia-Lora, A., Algarra, I., Collado, A., Garrido, F. (2003a) Tumour immunology, vaccination and escape strategies. Eur. J. Immunogenet. 30, 177-183. <https://doi.org/10.1046/j.1365-2370.2003.00384.x>
22. Garcia-Lora, A., Algarra, I., Garrido, F. (2003b) MHC class I antigens, immune surveillance, and tumour immune escape. J. Cell. Physiol. 195, 346-355. <https://doi.org/10.1002/jcp.10290>
23. Geppert, T. D., Lipsky, P. E. (1991) Association of various T cell-surface molecules with the cytoskeleton. Effect of cross-linking and activation. J. Immunol. 146, 3298-3305. <https://doi.org/10.4049/jimmunol.146.10.3298>
24. Gorelik, E., Kim, M., Duty, L., Henion, T., Galili, U. (1993) Control of metastatic properties of BL6 melanoma cells by H-2Kb gene: immunological and nonimmunological mechanisms. Clin. Exp. Metastasis 11, 439-452. <https://doi.org/10.1007/BF00054935>
25. Gorelik, E., Duty, L., Anaraki, F., Galili, U. (1995) Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection. Cancer Res. 55, 4168-4173.
26. Gorelik, E., Xu, F., Henion, T., Anaraki, F., Galili, U. (1997) Reduction of metastatic properties of BL6 melanoma cells expressing terminal fucose(alpha)1-2-galactose after alpha1,2-fucosyltransferase cDNA transfection. Cancer Res. 57, 332-336.
27. Gorelik, E., Galili, U., Raz, A. (2001) On the role of cell surface carbohydrates and their binding proteins (lectins) in tumour metastasis. Cancer Metastasis Rev. 20, 245-277. <https://doi.org/10.1023/A:1015535427597>
28. Gur, H., Geppert, T. D., Wacholtz, M. C., Lipsky, P. E. (1999) The cytoplasmic and the transmembrane domains are not sufficient for class I MHC signal transduction. Cell Immunol. 191, 105-116. <https://doi.org/10.1006/cimm.1998.1417>
29. Hahne, M., Rimoldi, D., Schroter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., et al. (1996) Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumour immune escape. Science 274, 1363-1366. <https://doi.org/10.1126/science.274.5291.1363>
30. Hammerling, G. J., Klar, D., Katzav, S., Segal, S., Feldman, M., Wallich, R., Hammerling, A. (1986) Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes. J. Immunogenet. 13, 153-157. <https://doi.org/10.1111/j.1744-313X.1986.tb01096.x>
31. Harris, P. E., Bian, H., Reed, E. F. (1997) Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: a possible mechanism for transplant atherosclerosis. J. Immunol. 159, 5697-5704. <https://doi.org/10.4049/jimmunol.159.11.5697>
32. Huang, X., Orucevic, A., Li, M., Gorelik, E. (2000) Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. Clin. Exp. Metastasis 18, 329-335. <https://doi.org/10.1023/A:1010867618014>
33. Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., Shatz, C. J. (2000) Functional requirement for class I MHC in CNS development and plasticity. Science 290, 2155-2159. <https://doi.org/10.1126/science.290.5499.2155>
34. Hwang, J. B., Frost, S. C. (1999) Effect of alternative glycosylation on insulin receptor processing. J. Biol. Chem. 274, 22813-22820. <https://doi.org/10.1074/jbc.274.32.22813>
35. Hwang, J. B., Hernandez, J., Leduc, R., Frost, S. C. (2000) Alternative glycosylation of the insulin receptor prevents oligomerization and acquisition of insulin-dependent tyrosine kinase activity. Biochim. Biophys. Acta 1499, 74-84. <https://doi.org/10.1016/S0167-4889(00)00109-9>
36. Ilangumaran, S., Arni, S., van Echten-Deckert, G., Borisch, B. Hoessli, D. C. (1999) Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes. Mol. Biol. Cell 10, 891-905. <https://doi.org/10.1091/mbc.10.4.891>
37. Isakov, N., Feldman, M., Segal, S. (1984) Loss of the H-2.33 private specificity by 3LL tumour cells correlates with the tumour potential to metastasize across the H-2K region genetic barriers. Exp. Clin. Immunogenet. 1, 170-174.
38. Katzav, S., Segal, S., Feldman, M. (1985) Metastatic capacity of cloned T10 sarcoma cells that differ in H-2 expression: inverse relationship to their immunogenic potency. J. Natl. Cancer Inst. 75, 307-318.
39. Kim, M., Rao, M. V., Tweardy, D. J., Prakash, M., Galili, U., Gorelik, E. (1993) Lectin-induced apoptosis of tumour cells. Glycobiology 3, 447-453. <https://doi.org/10.1093/glycob/3.5.447>
40. Kim, M., Duty, L., Herberman, R., Gorelik, E. (1994) Divergent effects of H-2K and H-2D genes on sensitivity of BL6 melanoma cells to NK cells or TNF-mediated cytotoxicity. Cell. Immunol. 155, 358-371. <https://doi.org/10.1006/cimm.1994.1129>
41. Kittur, D., Shimizu, Y., DeMars, R., Edidin, M. (1987) Insulin binding to human B lymphoblasts is a function of HLA haplotype. Proc. Natl. Acad. Sci. USA 84, 1351-1355. <https://doi.org/10.1073/pnas.84.5.1351>
42. Kusumi, A., Sako, Y. (1996) Cell surface organization by the membrane skeleton. Curr. Opin. Cell Biol. 8, 566-574. <https://doi.org/10.1016/S0955-0674(96)80036-6>
43. Lamberth, K., Claesson, M. H. (2001) Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in Tlymphoma cells. Tissue Antigens 58, 171-180. <https://doi.org/10.1034/j.1399-0039.2001.580305.x>
44. Lauri, D., De Giovanni, C., Biondelli, T., Lalli, E., Landuzzi, L., Facchini, A., Nicoletti, G., Nanni, P., Dejana, E., Lollini, P. L. (1993) Decreased adhesion to endothelial cells and matrix proteins of H-2Kb gene transfected tumour cells. Br. J. Cancer 68, 862-867. <https://doi.org/10.1038/bjc.1993.446>
45. Levin, I., Kuperman, O., Goldstein, J., Neumann, L., Segal, S., Kaneti, J., Lismer, L., Machpud, A., Klein, B. (1991) Cellular B-2 microglobulin expression as a prognostic indicator in renal cell carcinoma. Acta Oncol. 30, 941-945. <https://doi.org/10.3109/02841869109088247>
46. Levin, I., Klein, B., Segal, S., Eyal, A., Gopas, J., Kaneti, J,. Saadon, M., Kuperman, O. (1992) Expression of HLA class I-encoded cell surface antigens in transitional cell carcinoma of the urinary bladder. Tissue Antigens 39, 19-22. <https://doi.org/10.1111/j.1399-0039.1992.tb02150.x>
47. Levin, I., Klein, T., Kuperman, O., Segal, S., Shapira, J., Gal, R., Hart, Y., Klein, B. (1994) The expression of HLA class I antigen in prostate cancer in relation to tumour differentiation and patient survival. Cancer Detect. Prev. 18, 443-445.
48. Li, M., Muller, J., Xu, F., Hearing, V. J., Gorelik, E. (1996) Inhibition of melanoma-associated antigen expression and ecotropic retrovirus production in B16BL6 melanoma cells transfected with major histocompatibility complex class I genes. Cancer Res. 56, 4464-4474.
49. Liegler, T., Alexander, J., Cresswell, P., Goldfine, I., Goodenow, R. S. (1990) An analysis of insulin receptor expression and binding on MHC class I positive and negative human lymphoblastoid cells. J. Immunol. 145, 1788-1793. <https://doi.org/10.4049/jimmunol.145.6.1788>
50. Lopez-Botet, M., Llano, M., Navarro, F., Bellon, T. (2000) NK cell recognition of non-classical HLA class I molecules. Semin. Immunol. 12, 109-119. <https://doi.org/10.1006/smim.2000.0213>
51. Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R. C., Falasca, M. (2003) Insulin induces phosphatidylinositol-3phosphate formation through TC10 activation. EMBO J. 22, 4178-4189. <https://doi.org/10.1093/emboj/cdg402>
52. Matko, J., Bodnar, A., Vereb, G., Bene, L., Vamosi, G., Szentesi, G., Szollosi, J., Gaspar, R., Horejsi, V., Waldmann, T. A., Damjanovich, S. (2002) GPImicrodomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur. J. Biochem. 269, 1199-1208. <https://doi.org/10.1046/j.0014-2956.2002.02759.x>
53. Meruelo, D., Edidin, M. (1975) Association of mouse liver adenosine 3í:5í-cyclic monophosphate (cyclic AMP) levels with histocompatibility-2 genotype. Proc. Natl. Acad. Sci. USA 72, 2644-2648. <https://doi.org/10.1073/pnas.72.7.2644>
54. Moretta, L., Mingari, M. C., Pende, D., Bottino, C., Biassoni, R., Moretta, A. (1996) The molecular basis of natural killer (NK) cell recognition and function. J. Clin. Immunol. 16, 243-253. <https://doi.org/10.1007/BF01541388>
55. Nagy, P., Matyus, L., Jenei, A., Panyi, G., Varga, S., Matko, J., Szollosi, J., Gaspar, R., Jovin, T. M., Damjanovich, S. (2001) Cell fusion experiments reveal distinctly different association characteristics of cell-surface receptors. J. Cell. Sci. 114, 4063-4071. <https://doi.org/10.1242/jcs.114.22.4063>
56. Nagy, P., Vereb, G., Sebestyen, Z., Horvath, G., Lockett, S. J., Damjanovich, S., Park, J. W., Jovin, T. M., Szollosi, J. (2002) Lipid rafts and the local density of ErbB proteins influence the biological role of homoand heteroassociations of ErbB2. J. Cell. Sci. 115, 4251-4262. <https://doi.org/10.1242/jcs.00118>
57. Naranda, T., Goldstein, A., Olsson, L. (1997) A peptide derived from an extracellular domain selectively inhibits receptor internalization: target sequences on insulin and insulin-like growth factor 1 receptors. Proc. Natl. Acad. Sci. USA 94, 11692-11697. <https://doi.org/10.1073/pnas.94.21.11692>
58. Nath, N., Bian, H., Reed, E. F., Chellappan, S. P. (1999) HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J. Immunol. 162, 5351-5358. <https://doi.org/10.4049/jimmunol.162.9.5351>
59. Olsson, L., Goldstein, A., Stagsted, J. (1994) Regulation of receptor internalization by the major histocompatibility complex class I molecule. Proc. Natl. Acad. Sci. USA 91, 9086-9090. <https://doi.org/10.1073/pnas.91.19.9086>
60. Pamer, E., Cresswell, P. (1998) Mechanisms of MHC class Irestricted antigen processing. Annu. Rev. Immunol. 16, 323-358. <https://doi.org/10.1146/annurev.immunol.16.1.323>
61. Phillips, M. L., Moule, M. L., Delovitch, T. L., Yip, C. C. (1986) Class I histocompatibility antigens and insulin receptors: evidence for interactions. Proc. Natl. Acad. Sci. USA 83, 3474-3478. <https://doi.org/10.1073/pnas.83.10.3474>
62. Prezioso, J. A., Hearing, V. J., Muller, J., Urabe, K., Wang, N., Gorelik, E. (1995) Impairment of the melanogenic pathway in B16 melanoma cells transfected with class I H-2 genes. Melanoma Res. 5, 15-25. <https://doi.org/10.1097/00008390-199502000-00003>
63. Prior, I. A., Hancock, J. F. (2001) Compartmentalization of Ras proteins. J. Cell Sci. 114, 1603-1608. <https://doi.org/10.1242/jcs.114.9.1603>
64. Ramachandra, L., Chu, R. S., Askew, D., Noss, E. H., Canaday, D. H., Potter, N. S., Johnsen, A., Krieg, A. M., Nedrud, J. G., Boom, W. H., Harding, C. V. (1999) Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses. Immunol. Rev. 168, 217-239. <https://doi.org/10.1111/j.1600-065X.1999.tb01295.x>
65. Ramalingam, T. S., Chakrabarti, A., Edidin, M. (1997) Interaction of class I human leukocyte antigen (HLA-I) molecules with insulin receptors and its effect on the insulin-signaling cascade. Mol. Biol. Cell. 8, 2463-2474. <https://doi.org/10.1091/mbc.8.12.2463>
66. Reiland, J., Edidin, M. (1993) Chemical cross-linking detects association of insulin receptors with four different class I human leukocyte antigen molecules on cell surfaces. Diabetes 42, 619-625. <https://doi.org/10.2337/diab.42.4.619>
67. Ruhwald, M., Pedersen, A. E., Claesson, M. H. (1999) MHC class I cross-talk with CD2 and CD28 induces specific intracellular signalling and leads to growth retardation and apoptosis via a p56(lck)-dependent mechanism. Exp. Clin. Immunogenet. 16, 199-211. <https://doi.org/10.1159/000019112>
68. Scofield, V. L., Schlumpberger, J. M., West, L. A., Weissman, I. L. (1982) Protochordate allorecognition is controlled by a MHC-like gene system. Nature 295, 499-502. <https://doi.org/10.1038/295499a0>
69. Segal, S., Tartakovsky, B., Katzav, S., DeBaetselier, P. (1980) The immunologic basis of the fetal-maternal relationship. Transplant. Proc. 12, 582-587.
70. Seliger, B., Maeurer, M. J., Ferrone, S. (2000) Antigen-processing machinery breakdown and tumour growth. Immunol. Today 21, 455-464. <https://doi.org/10.1016/S0167-5699(00)01692-3>
71. Shalev, A., Greenberg, A. H., Logdberg, L., Bjorck, L. (1981) beta 2-Microglobulin-like molecules in low vertebrates and invertebrates. J. Immunol. 127, 1186-1191. <https://doi.org/10.4049/jimmunol.127.3.1186>
72. Shalev, A., Pla, M., Ginsburger-Vogel, T., Echalier, G., Logdberg, L., Bjorck, L., Colombani, J., Segal, S. (1983) Evidence for beta 2-microglobulin-like and H-2-like antigenic determinants in Drosophila. J. Immunol. 130, 297-302. <https://doi.org/10.4049/jimmunol.130.1.297>
73. Shalev, A., Caspi, R. R., Logdberg, L., Bjorck, L., Segal, S., Avtalion, R. R. (1984) Specific activity of carp antisera against beta 2-microglobulin (beta 2m) and evidence for a beta 2m homologue in carp (Cyprinus carpio). Dev. Comp. Immunol. 8, 639-648. <https://doi.org/10.1016/0145-305X(84)90096-X>
74. Simons, K., Ikonen, E. (1997) Functional rafts in cell membranes. Nature 387, 569-572. <https://doi.org/10.1038/42408>
75. Simonsen, M., Skjodt, K., Crone, M., Sanderson, A., FujitaYamaguchi, Y., Due, C., Ronne, E., Linnet, K., Olsson, L. (1985) Compound receptors in the cell membrane: ruminations from the borderland of immunology and physiology. Prog. Allergy 36, 151-176.
76. Skov, S., Bregenholt, S., Claesson, M. H. (1997a) MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis. J. Immunol. 158, 3189-3196. <https://doi.org/10.4049/jimmunol.158.7.3189>
77. Skov, S., Odum, N., Claesson, M. H. (1995) MHC class I signaling in T cells leads to tyrosine kinase activity and PLCgamma 1 phosphorylation. J. Immunol. 154, 1167-1176. <https://doi.org/10.4049/jimmunol.154.3.1167>
78. Skov, S., Klausen, P., Claesson, M. H. (1997b) Ligation of major histocompatibility complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis. J. Cell Biol. 139, 1523-1531. <https://doi.org/10.1083/jcb.139.6.1523>
79. Skov, S., Nielsen, M., Bregenholt, S., Odum, N., Claesson, M. H. (1998) Activation of Stat-3 is involved in the induction of apoptosis after ligation of major histocompatibility complex class I molecules on human Jurkat T cells. Blood 91, 3566-3573. <https://doi.org/10.1182/blood.V91.10.3566>
80. Solheim, J. C. (1999) Class I MHC molecules: assembly and antigen presentation. Immunol. Rev. 172, 11-19. <https://doi.org/10.1111/j.1600-065X.1999.tb01352.x>
81. Stagsted, J., Reaven, G. M., Hansen, T., Goldstein, A., Olsson, L. (1990) Regulation of insulin receptor functions by a peptide derived from a major histocompatibility complex class I antigen. Cell 62, 297-307. <https://doi.org/10.1016/0092-8674(90)90367-N>
82. Stagsted, J. (1998) Journey beyond immunology. Regulation of receptor internalization by major histocompatibility complex class I (MHC-I) and effect of peptides derived from MHC-I. APMIS 85 (Suppl.), 1-40.
83. Syken, J., Shatz, C. J. (2003) Expression of T cell receptor beta locus in central nervous system neurons. Proc. Natl. Acad. Sci. USA 100, 13048-13053. <https://doi.org/10.1073/pnas.1735415100>
84. Szollosi, J., Horejsi, V., Bene, L., Angelisova, P., Damjanovich, S. (1996) Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J. Immunol. 157, 2939-2946. <https://doi.org/10.4049/jimmunol.157.7.2939>
85. Vainio, S., Heino, S., Mansson, J. E., Fredman, P., Kuismanen, E., Vaarala, O., Ikonen, E. (2002) Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae. EMBO Rep. 3, 95-100. <https://doi.org/10.1093/embo-reports/kvf010>
86. Verland, S., Simonsen, M., Gammeltoft, S., Allen, H., Flavell, R. A., Olsson, L. (1989) Specific molecular interaction between the insulin receptor and a D product of MHC class I. J. Immunol. 143, 945-951. <https://doi.org/10.4049/jimmunol.143.3.945>
87. Waheed, A. A., Jones, T. L. (2002) Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts. J. Biol. Chem. 277, 32409-32412. <https://doi.org/10.1074/jbc.C200383200>
88. Wallich, R., Bulbuc, N., Hammerling, G. J., Katzav, S., Segal, S., Feldman, M. (1985) Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. Nature 315, 301-305. <https://doi.org/10.1038/315301a0>
89. Xu, F., Carlos, T., Li, M., Sanchez-Sweatman, O., Khokha, R., Gorelik, E. (1998) Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes. Clin. Exp. Metastasis 16, 358-370. <https://doi.org/10.1023/A:1006569631330>
90. Yewdell, J. W., Reits, E., Neefjes, J. (2003) Making sense of mass destruction: quantitating MHC class I antigen presentation. Nat. Rev. Immunol. 3, 952-961. <https://doi.org/10.1038/nri1250>
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