Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2004, 50, 43-57

https://doi.org/10.14712/fb2004050020043

Comparative Gene Map of Hypertriglyceridaemia

Ondřej Šeda1,2,3

1Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada
2Department of Metabolism and Diabetes, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
3Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic

Elevated triglyceride levels in the circulation are currently recognized as an independent risk factor for coronary artery disease. Hypertriglyceridaemia represents one of the attributes of metabolic syndrome and is present in the most common genetic dyslipidaemia, the familial combined hyperlipidaemia. The factual concentration of triglycerides is determined by a complex interaction of environmental and genetic components. Deeper understanding of the causative gene variants and the mode of their participation in the pathogenesis of hypertriglyceridaemia is required for devising efficient therapy of hypertriglyceridaemia. This is the first systematic review of linkage and candidate gene studies dealing with the dissection of genetic determinants of (hyper)triglyceridaemia in human and two major mammalian model species, mouse and rat. Based on the merged sets of data, a synthetic view of the genetic component of triglyceridaemia, the "hypertriglyceridaemia gene map", is presented.

Funding

This work was supported by following grants: GAČR 301/04/0248 from the Grant Agency of the Czech Republic, GAAV ČR B5105401 from the Grant Agency of the Academy of Sciences of the Czech Republic, NR/7888 from the Internal Grant Agency of the Ministry of Health of the Czech Republic. O. Šeda is a recipient of TACTICS fellowship.

References

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