Haemochromatosis-Causing Mutations C282Y and H63D Are Not Risk Factors for Coronary Artery Disease in Caucasians with Type 2 Diabetes

Zorc, M.; Hruškovičová, H.; Globočnik Petrovič, M.; Milčič, M.; Peterlin, B.; Petrovič, Daniel

doi:10.14712/fb2004050020069

Fol. Biol. 2004, 50, 69-70

https://doi.org/10.14712/fb2004050020069

Haemochromatosis-Causing Mutations C282Y and H63D Are Not Risk Factors for Coronary Artery Disease in Caucasians with Type 2 Diabetes

M. Zorc¹, H. Hruškovičová², M. Globočnik Petrovič³, M. Milčič², B. Peterlin², Daniel Petrovič¹

¹Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
²Division of Medical Genetics, Department of Obstetrics and Gynecology, Medical Centre Ljubljana, Ljubljana, Slovenia
³Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia

Received February 2004
Accepted March 2004

Iron metabolism might be involved in the pathogenesis of CAD, and C282Y and H63D mutations in the HFE gene are associated with increased serum iron levels and net iron accumulation. The aim of this study was to look for a relationship between the C282Y and H63D gene mutations of the HFE gene and coronary artery disease (CAD) in a group of patients with type 2 diabetes lasting more than 10 years. The C282Y and H63D gene mutations were tested in 338 Caucasians with type 2 diabetes: 156 cases with CAD and 182 subjects with no history of CAD. The C282Y and the H63D HFE gene distributions in patients with CAD (C282Y: YY 0.6%, CY 9.0%, CC 90.4%; H63D: DD 3.8%, HD 21.8%, HH 74.4%) were not significantly different from those of diabetic subjects without CAD (C282Y: YY 0%, CY 8.2%, CC 91.8%; H63D: DD 2.2%, HD 20.3%, HH 77.5%). In conclusion, we failed to demonstrate that the C282Y and H63D HFE gene mutations were risk factors for CAD in Caucasians with type 2 diabetes lasting longer than 10 years.