Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2004, 50, 69-70

https://doi.org/10.14712/fb2004050020069

Haemochromatosis-Causing Mutations C282Y and H63D Are Not Risk Factors for Coronary Artery Disease in Caucasians with Type 2 Diabetes

M. Zorc1, H. Hruškovičová2, M. Globočnik Petrovič3, M. Milčič2, B. Peterlin2, Daniel Petrovič1

1Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
2Division of Medical Genetics, Department of Obstetrics and Gynecology, Medical Centre Ljubljana, Ljubljana, Slovenia
3Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia

Received February 2004
Accepted March 2004

References

1. Campbell, S., George, D. K., Robb, S. D., Spooner, R., McDonagh, T. A., Dargie, H. J., Mills, P. R. (2003) The prevalence of haemochromatosis gene mutations in the West of Scotland and their relation to ischaemic heart disease. Heart 89, 1023-1026. <https://doi.org/10.1136/heart.89.9.1023>
2. Gunn, I. R., Maxwell, F. K., Gaffney, D., McMahon, A. D., Packard, C. J. (2004) Haemochromatosis gene mutations and risk of coronary heart disease: a west of Scotland coronary prevention study (WOSCOPS) substudy. Heart 90, 304-306. <https://doi.org/10.1136/hrt.2003.015149>
3. Kankova, K., Jansen E. H., Marova, I., Stejskalova, A., Pacal, L., Muzik, J., Vacha, J. (2002) Relations among serum ferritin, C282Y and H63D mutations in the HFE gene and type 2 diabetes mellitus in the Czech population. Exp. Clin. Endocrinol. Diabetes 110, 223-229. <https://doi.org/10.1055/s-2002-33071>
4. Magnusson, M. K., Sigfusson, N., Sigvaldason, H., Johannesson, G. M., Magnusson, S., Thorgeirsson, G. (1994) Low iron-binding capacity as a risk factor for myocardial infarction. Circulation 89, 102-108. <https://doi.org/10.1161/01.CIR.89.1.102>
5. Malecki, M. T., Klupa, T., Walus, M., Czogala, W., Greenlaw, P., Sieradzki, J. (2003) A search for association between hereditary hemochromatosis HFE gene mutations and type 2 diabetes mellitus in a Polish population. Med. Sci. Monit. 9, BR91-BR95.
6. Njajou, O. T., Alizadeh, B. Z., Vaessen, N., Vergeer, J., Houwing-Duistermaat, J., Hofman, A., Pols, H. A., Van Duijn, C. M.(2002) The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis. Diabetes Care 25, 2112-2113. <https://doi.org/10.2337/diacare.25.11.2112-a>
7. Peterlin, B., Globocnik Petrovic, M., Makuc, J., Hawlina, M., Petrovic, D. (2003) A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes. J. Hum. Genet. 48, 646-649. <https://doi.org/10.1007/s10038-003-0094-3>
8. Rasmussen, M. L., Folsom, A. R., Catellier, D. J., Tsai, M. Y., Garg, U., Eckfeldt, J. H. (2001) A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the ARIC study. Atherosclerosis 154, 739-746. <https://doi.org/10.1016/S0021-9150(00)00623-7>
9. Sempos, C. T., Looker, A. C., Gillum, R. F., Makuc, D. M. (1994) Body iron stores and the risk of coronary heart disease. N. Engl. J. Med. 330, 1119-1124. <https://doi.org/10.1056/NEJM199404213301604>
10. Tuomainen, T. P., Kontula, K., Nyyssonen, K., Lakka, T. A., Helio, T., Salonen, J. (1999) Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation: a prospective cohort study in men in eastern Finland. Circulation 100, 1274-1279. <https://doi.org/10.1161/01.CIR.100.12.1274>
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