Fol. Biol. 2004, 50, 100-106
https://doi.org/10.14712/fb2004050030100
Prospects for an Effective T Cell-Based Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
References
1. 1994) Cytotoxic T lymphocyte activity and CD8 subpopulations in children at risk of HIV infection. Clin. Exp. Immunol. 97, 61-67.
< , M. C., Watret, K. C., Mok, J. Y., Bird, A. G., Froebel, K. S. (https://doi.org/10.1111/j.1365-2249.1994.tb06580.x>
2. 2002) Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. J. Virol. 76, 4108-4112.
< , T. M., Mortara, L., Mothe, B. R., Liebl, M., Jing, P., Calore, B., Piekarczyk, M., Ruddersdorf, R., OíConnor, D. H., Wang, X., Wang, C., Allison, D. B., Altman, J. D., Sette, A., Desrosiers, R. C., Sutter, G., Watkins, D. I. (https://doi.org/10.1128/JVI.76.8.4108-4112.2002>
3. 2003) Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. Aids 17, 2581-2591.
< , M., Addo, M. M., Rosenberg, E. S., Hecht, F. M., Lee, P. K., Vogel, M., Yu, X. G., Draenert, R., Johnston, M. N., Strick, D., Allen, T. M., Feeney, M. E., Kahn, J. O., Sekaly, R. P., Levy, J. A., Rockstroh, J. K., Goulder, P. J., Walker, B. D. (https://doi.org/10.1097/00002030-200312050-00005>
4. 2002) Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection. J. Infect. Dis. 185, 1355-1358.
< , J., Kinloch, S., Sonnerborg, A., Nilsson, J., Fehniger, T. E., Spetz, A. L., Behbahani, H., Goh, L. E., McDade, H., Gazzard, B., Stellbrink, H., Cooper, D., Perrin, L. (https://doi.org/10.1086/340124>
5. 2002) Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8, 379-385.
< , V., Dunbar, P. R., Callan, M., Klenerman, P., Gillespie, G. M., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., Little, S., Havlir, D. V., Richman, D. D., Gruener, N., Pape, G., Waters, A., Easterbrook, P., Salio, M., Cerundolo, V., McMichael, A. J., RowlandJones, S. L. (https://doi.org/10.1038/nm0402-379>
6. 2002) Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes. Eur. J. Immunol. 32, 2644-2652.
< , C. A., Guillon, C., Baalen, M. v. M., Verschuren, E. J., Boers, P. H., Osterhaus, A. D., Gruters, R. A. (https://doi.org/10.1002/1521-4141(200209)32:9<2644::AID-IMMU2644>3.0.CO;2-R>
7. 2002) Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415, 335-339.
< , D. H., Kunstman, J., Kuroda, M. J., Schmitz, J. E., Santra, S., Peyerl, F. W., Krivulka, G. R., Beaudry, K., Lifton, M. A., Gorgone, D. A., Montefiori, D. C., Lewis, M. G., Wolinsky, S. M., Letvin, N. L. (https://doi.org/10.1038/415335a>
8. 2000) Control of viraemia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486-492.
< , D. H., Santra, S., Schmitz, J. E., Kuroda, M. J., Fu, T. M., Wagner, W., Bilska, M., Craiu, A., Zheng, X. X., Krivulka, G. R., Beaudry, K., Lifton, M. A., Nickerson, C. E., Trigona, W. L., Punt, K., Freed, D. C., Guan, L., Dubey, S., Casimiro, D., Simon, A., Davies, M. E., Chastain, M., Strom, T. B., Gelman, R. S., Montefiori, D. C., Lewis, M. G., Letvin, N. L. (https://doi.org/10.1126/science.290.5491.486>
9. 1994) Virus-specific CD8+ CTL activity associated with control of viraemia in primary HIV-1 infection. J. Virol. 68, 6103-6110.
< , P., Lewicki, H., Hahn, B. E., Shaw, G. M., Oldstone, M. B. (https://doi.org/10.1128/jvi.68.9.6103-6110.1994>
10. 2004a) Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science 303, 316.
< , D. R., Desrosiers, R. C., Doms, R. W., Feinberg, M. B., Gallo, R. C., Hahn, B., Hoxie, J. A., Hunter, E., Korber, B., Landay, A., Lederman, M. M., Lieberman, J., McCune, J. M., Moore, J. P., Nathanson, N., Picker, L., Richman, D., Rinaldo, C., Stevenson, M., Watkins, D. I., Wolinksky, S. M., Zack, J. A. (https://doi.org/10.1126/science.1094620>
11. 2004b) HIV vaccine design and the neutralizing antibody problem. Nat. Immunol. 5, 233-236.
< , D. R., Desrosiers, R. C., Doms, R. W., Koff, W. C., Kwong, P. D., Moore, J. P., Nabel, G. J., Sodroski, J., Wilson, I. A., Wyatt, R. T. (https://doi.org/10.1038/ni0304-233>
12. 1998) Early HIVspecific cytotoxic T lymphocytes and disease progression in children born to HIV-infected mothers. AIDS Res. Hum. Retroviruses 14, 1435-1444.
< , F., Burgard, M., Teglas, J. P., Bui, E., Rouzioux, C., Mayaux, M. J., Blanche, S., Riviere, Y. (https://doi.org/10.1089/aid.1998.14.1435>
13. 2002) Inverse correlation between memory Gag-specific cytotoxic T lymphocytes and viral replication in human immunodeficiency virus-infected children. J. Infect. Dis. 186, 1589-1596.
< , F., Le Chenadec, J., Corre, B., Porrot, F., Burgard, M., Rouzioux, C., Blanche, S., Mayaux, M. J., Riviere, Y. (https://doi.org/10.1086/345482>
14. 1999) Control of SHIV-89.6P infection of cynomolgus monkeys by HIV-1 Tat protein vaccine. Nat. Med. 5, 643-650.
< , A., Caputo, A., Fracasso, C., Maggiorella, M. T., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, M. L., Betti, M., Borsetti, A., Belli, R., Akerblom, L., Corrias, F., Butto, S., Heeney, J., Verani, P., Titti, F., Ensoli, B. (https://doi.org/10.1038/9488>
15. 1999) HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage. Science 283, 1748-1752.
< , M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., OíBrien, S. J. (https://doi.org/10.1126/science.283.5408.1748>
16. 2001) Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 410, 106-111.
< , P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., Foster, R., Rowland-Jones, S., Sekaly, R. P., McMichael, A. J., Pantaleo, G. (https://doi.org/10.1038/35065118>
17. 1992) Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1-infected mothers. Eur. J. Immunol. 22, 2211-2217.
< , R., Langlade-Demoyen, P., Marescot, M. R., Blanche, S., Blondin, G., Wain-Hobson, S., Griscelli, C., Vilmer, E., Plata, F. (https://doi.org/10.1002/eji.1830220905>
18. 1994) Mother-to-child transmission of human immunodeficiency virus type 1: report from the Nairobi Study. J. Infect. Dis. 170, 1134-1140.
< , P., Embree, J. E., Kreiss, J. K., Ndinya-Achola, J. O., Braddick, M., Temmerman, M., Nagelkerke, N. J., Maitha, G., Holmes, K. K., Piot, P., et al. (https://doi.org/10.1093/infdis/170.5.1134>
19. 1994) Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers. J. Infect. Dis. 170, 1296-1299.
< , A., Cirillo, C., Moretta, L. (https://doi.org/10.1093/infdis/170.5.1296>
20. 1997) Late postnatal mother-to-child transmission of HIV-1 in Abidjan, Cote díIvoire. Lancet 349, 1054-1059.
< , E. R., Wiktor, S. Z., Satten, G. A., Adjorlolo-Johnson, G. T., Sibailly, T. S., Ou, C. Y., Karon, J. M., Brattegaard, K., Whitaker, J. P., Gnaore, E., De Cock, K. M., Greenberg, A. E. (https://doi.org/10.1016/S0140-6736(96)06444-6>
21. 2002) Neutralizing antibodies against HIV ñ back in the major leagues? Curr. Opin. Immunol. 14, 495-502.
< , F., Ruprecht, R. M. (https://doi.org/10.1016/S0952-7915(02)00362-X>
22. 2004) Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nat. Med. 10, 275-281.
< , T. C., Dodds, E. J., Yant, L. J., Vojnov, L., Rudersdorf, R., Cullen, C., Evans, D. T., Desrosiers, R. C., Mothe, B. R., Sidney, J., Sette, A., Kunstman, K., Wolinsky, S., Piatak, M., Lifson, J., Hughes, A. L., Wilson, N., OíConnor, D. H., Watkins, D. I. (https://doi.org/10.1038/nm998>
23. 1995) Early suppression of SIV replication by CD8+ nef-specific cytotoxic T cells in vaccinated animals. Nat. Med. 1, 1167-1173.
< , A., Cranage, M., Cook, N., Almond, N., Bootman, J., Rud, R., Silvera, P., Dennis, M., Corcoran, T., Stott, J., McMichael, A., Gotch, F. (https://doi.org/10.1038/nm1195-1167>
24. 1990) Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs. Blood 76, 1924-1926.
< , J., Cory, J. M., Hewlett, I. K., Epstein, J. S., Eyster, M. E. (https://doi.org/10.1182/blood.V76.10.1924.1924>
25. 1999) Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J. Infect. Dis. 179, 548-557.
< , W. C., Markee, J., Akridge, R. E., Meldorf, M., Musey, L., Karchmer, T., Krone, M., Collier, A., Corey, L., Emerman, M., McElrath, M. J. (https://doi.org/10.1086/314632>
26. 2001) Mother-to-child transmission of HIV infection and CTL escape through HLAA2-SLYNTVATL epitope sequence variation. Immunol. Lett. 79, 109-116.
< , P. J., Pasquier, C., Holmes, E. C., Liang, B., Tang, Y., Izopet, J., Saune, K., Rosenberg, E. S., Burchett, S. K., McIntosh, K., Barnardo, M., Bunce, M., Walker, B. D., Brander, C., Phillips, R. E. (https://doi.org/10.1016/S0165-2478(01)00272-3>
27. 1997) Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3, 212-217.
< , P. J. R., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giangrande, P., Luzzi, G., Morgan, B., Edwards, A., McMichael, A. J., RowlandJones, S. (https://doi.org/10.1038/nm0297-212>
28. 2003) Development of prophylactic AIDS vaccines: the current state of affairs. Curr. Opin. Mol. Ther. 5, 25-33.
, T. (
29. 1996) Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res. Hum. Retroviruses 12, 585-592.
< , T., Harrer, E., Kalams, S. A., Elbeik, T., Staprans, S. I., Feinberg, M. B., Cao, Y., Ho, D. D., Yilma, T., Caliendo, A. M., Johnson, R. P., Buchbinder, S. P., Walker, B. D. (https://doi.org/10.1089/aid.1996.12.585>
30. 1999) Dramatic rise in plasma viraemia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189, 991-998.
< , X., Bauer, D. E., Tuttleton, S. E., Lewin, S., Gettie, A., Blanchard, J., Irwin, C. E., Safrit, J. T., Mittler, J., Weinberger, L., Kostrikis, L. G., Zhang, L., Perelson, A. S., Ho, D. D. (https://doi.org/10.1084/jem.189.6.991>
31. 2001) Polymorphisms in HLA class I gene associated with both favourable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T lymphocytes responses to ALVAC-HIV recombinant canarypox vaccines. J. Virol. 75, 8681-8689.
< , R. A., Rivers, C., Tang, J., Bender, T. J., Goepfert, P. A., El Habib, R., Weinhold, K., Mulligan, M. J., Group, N. A. V. E. (https://doi.org/10.1128/JVI.75.18.8681-8689.2001>
32. 2000) HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J. Immunol. 164, 1602-1611.
< , R., Plummer, F. A., Kimani, J., Dong, T., Kiama, P., Rostron, T., Njagi, E., MacDonald, K. S., Bwayo, J. J., McMichael, A. J., Rowland-Jones, S. L. (https://doi.org/10.4049/jimmunol.164.3.1602>
33. 2001) Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses. J. Clin. Invest. 107, 341-349.
< , R., Rowland-Jones, S. L., Kimani, J., Dong, T., Yang, H. B., Kiama, P., Rostron, T., Njagi, E., Bwayo, J. J., MacDonald, K. S., McMichael, A. J., Plummer, F. A. (https://doi.org/10.1172/JCI10714>
34. 2001) Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med. 193, 375-386.
< , A. D., Long, C., Holmes, E. C., Allen, R. L., Wilson, J., Conlon, C., Workman, C., Shaunak, S., Olson, K., Goulder, P., Brander, C., Ogg, G., Sullivan, J. S., Dyer, W., Jones, I., McMichael, A. J., Rowland-Jones, S., Phillips, R. E. (https://doi.org/10.1084/jem.193.3.375>
35. 1997) Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with the control of acute HIV-1 infection in macaques. J. Infect. Dis. 176, 1188-1197.
< , S. J., Woodward, A., Zhao, A. (https://doi.org/10.1086/514112>
36. 2002) HIV: current opinion in escapology. Curr. Opin. Microbiol. 5, 408-413.
< , P., Wu, Y., Phillips, R. (https://doi.org/10.1016/S1369-5274(02)00339-9>
37. 1994) Temporal association of cellular immune responses with the initial control of viraemia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650-4655.
< , R. A., Safrit, J. T., Cao, Y., Andrews, C. A., McLoed, G., Borkowsky, W., Farthing, C., Ho, D. D. (https://doi.org/10.1128/jvi.68.7.4650-4655.1994>
38. 2004) HIV evolution: CTL escape mutation and reversion after transmission. Nat. Med. 10, 282-289.
< , A. J., Pfafferott, K. J., Chetty, P., Draenert, R., Addo, M. M., Feeney, M., Tang, Y., Holmes, E. C., Allen, T., Prado, J. G., Altfeld, M., Brander, C., Dixon, C., Ramduth, D., Jeena, P., Thomas, S. A., John, A. S., Roach, T. A., Kupfer, B., Luzzi, G., Edwards, A., Taylor, G., Lyall, H., Tudor-Williams, G., Novelli, V., Martinez-Picado, J., Kiepiela, P., Walker, B. D., Goulder, P. J. (https://doi.org/10.1038/nm992>
39. 1995) HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J. Immunol. 154, 433-443.
< , K., Holmes, D., Hereema, A., Wong, J., Panicali, D. L., Sullivan, J. L. (https://doi.org/10.4049/jimmunol.154.1.433>
40. 2002) Pediatric HIV-1 infection: advances and remaining challenges. AIDS Rev. 4, 21-26.
, K., Sullivan, J. L. (
41. 2003) Functional and morphological development of lymphoid tissues and immune regulatory and effector function in rhesus monkeys: cytokine-secreting cells, immunoglobulin-secreting cells, and CD5(+) B-1 cells appear early in fetal development. Clin. Diagn. Lab. Immunol. 10, 140-153.
, N., Tarantal, A. F., Lu, F. X., Rourke, T., Marthas, M. L., McChesney, M. B., Hendrickx, A. G., Miller, C. J. (
42. 2003) Mature CD8(+) T lymphocyte response to viral infection during fetal life. J. Clin. Invest. 111, 1747-1755.
< , A., Appay, V., Van Der Sande, M., Dulphy, N., Liesnard, C., Kidd, M., Kaye, S., Ojuola, O., Gillespie, G. M., Vargas Cuero, A. L., Cerundolo, V., Callan, M., McAdam, K. P., Rowland-Jones, S. L., Donner, C., McMichael, A. J., Whittle, H. (https://doi.org/10.1172/JCI200317470>
43. 1994) Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 265, 1587-1590.
< , R., Kanki, P., Thior, I., Travers, K., Eisen, G., Siby, T., Traore, I., Hsieh, C. C., Dia, M. C., Gueye, E. H., et al. (https://doi.org/10.1126/science.7915856>
44. 1998) Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72, 164-169.
< , T., Shibata, R., Siemon, C., Connors, M., Lane, H. C., Martin, M. A. (https://doi.org/10.1128/JVI.72.1.164-169.1998>
45. 1997) HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIVseropositive individuals. Nat. Med. 3, 1250-1257.
< , S., Trabattoni, D., Lo Caputo, S., Piconi, S., Ble, C., Meacci, F., Ruzzante, S., Salvi, A., Semplici, F., Longhi, R., Fusi, M. L., Tofani, N., Biasin, M., Villa, M. L., Mazzotta, F., Clerici, M. (https://doi.org/10.1038/nm1197-1250>
46. 2001) Morbidity and mortality in breastfed and formula-fed infants of HIV-1-infected women: A randomized clinical trial. JAMA 286, 2413-2420.
< , D., Nduati, R., John, G., Reilly, M., Richardson, B., Mwatha, A., Ndinya-Achola, J., Bwayo, J., Kreiss, J. (https://doi.org/10.1001/jama.286.19.2413>
47. 1998) T cell responses and viral escape. Cell 93, 673-676.
< , A. (https://doi.org/10.1016/S0092-8674(00)81428-2>
48. 1998) Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. AIDS Res. Hum. Retroviruses 14, 607-617.
< , H., Monard, S., Pollack, H., Ip, J., Rochford, G., Wu, L., Hoxie, J., Borkowsky, W., Ho, D. D., Moore, J. P. (https://doi.org/10.1089/aid.1998.14.607>
49. 2002) Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296, 1439-1443.
< , C. B., John, M., James, I. R., Christiansen, F. T., Witt, C. S., Mallal, S. A. (https://doi.org/10.1126/science.1069660>
50. 2002) Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies. DNA Cell. Biol. 21, 659-664.
< , D. H., Allen, T. M., Watkins, D. I. (https://doi.org/10.1089/104454902760330192>
51. 1998) Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279, 2103-2106.
< , G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland-Jones, S. L., Cerundolo, V., Hurley, A., Markowitz, M., Ho, D. D., Nixon, D. F., McMichael, A. J. (https://doi.org/10.1126/science.279.5359.2103>
52. 1999) Vaccination with Rev and Tat against AIDS. Vaccine 17, 2713-2714.
< , A. D., van Baalen, C. A., Gruters, R. A., Schutten, M., Siebelink, C. H., Hulskotte, E. G., Tijhaar, E. J., Randall, R. E., van Amerongen, G., Fleuchaus, A., Erfle, V., Sutter, G. (https://doi.org/10.1016/S0264-410X(98)00498-8>
53. 1996) Fetal or neonatal infection with attenuated simian immunodeficiency virus results in protective immunity against oral challenge with pathogenic SIVmac251. Virology 222, 275-278.
< , M. G., Miller, C. J., Tarantal, A. F., Marthas, M. L., Greene, T. P., Collins, J. R., van Rompay, K. K., McChesney, M. B. (https://doi.org/10.1006/viro.1996.0420>
54. 1997) Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J. Exp. Med. 185, 1153-1161.
< , C. A., Sullivan, J. L., Panicali, D., Luzuriaga, K. (https://doi.org/10.1084/jem.185.7.1153>
55. 1995) Envspecific cytotoxic T lymphocytes in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J. Clin. Invest. 96, 867-876.
< , L. A., Sullivan, J., Berzofsky, J. A., Clerici, M., Kessler, H. A., Landay, A. L., Shearer, G. M. (https://doi.org/10.1172/JCI118133>
56. 1998) Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Curr. Biol. 8, 355-358.
< , D. A., Sewell, A. K., Dong, T., Tan, R., Goulder, P. J., Rowland-Jones, S. L., Phillips, R. E. (https://doi.org/10.1016/S0960-9822(98)70138-1>
57. 2003a) Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers. J. Infect. Dis. 187, 736-740.
< , B. A., John-Stewart, G. C., Hughes, J. P., Nduati, R., Mbori-Ngacha, D., Overbaugh, J., Kreiss, J. K. (https://doi.org/10.1086/374272>
58. 2003b) Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection. J. Virol. 77, 7120-7123.
< , B. A., Mbori-Ngacha, D., Lavreys, L., JohnStewart, G. C., Nduati, R., Panteleeff, D. D., Emery, S., Kreiss, J. K., Overbaugh, J. (https://doi.org/10.1128/JVI.77.12.7120-7123.2003>
59. 2003) Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. J. Infect. Dis. 187, 741-747.
< , C. M., Nduati, R. W., Richardson, B. A., Steele, M. S., John-Stewart, G. C., Mbori-Ngacha, D. A., Kreiss, J. K., Overbaugh, J. (https://doi.org/10.1086/374273>
60. 1995) HIV-specific cytotoxic T-cells in HIVexposed but uninfected Gambian women. Nat. Med. 1, 59-64.
< , S., Sutton, J., Ariyoshi, K., Dong, T., Gotch, F., McAdam, S., Whitby, D., Sabally, S., Gallimore, A., Corrah, T., Takiguchi, M., Schultz, T., McMichael, A., Whittle, H. (https://doi.org/10.1038/nm0195-59>
61. 1998) Cytotoxic T cell responses to multiple conserved epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Inv. 102, 1758-1765.
< , S. L., Dong, T., Fowke, K. R., Kimani, J., Krausa, P., Newell, H., Blanchard, T., Ariyoshi, K., Oyugi, J., Ngugi, E., Bwayo, J. J., MacDonald, K. S., McMichael, A. J., Plummer, F. A. (https://doi.org/10.1172/JCI4314>
62. 1995) Immune responses in HIV-exposed seronegatives: have they repelled the virus? Curr. Opin. Immunol. 7, 448-455.
< , S. L., McMichael, A. (https://doi.org/10.1016/0952-7915(95)80087-5>
63. 1993) HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 341, 860-861.
< , S. L., Nixon, D. F., Aldhous, M. C., Gotch, F., Ariyoshi, K., Hallam, N., Kroll, J. S., Froebel, K., McMichael, A. (https://doi.org/10.1016/0140-6736(93)93063-7>
64. 2004) Immunoprophylaxis to prevent mother-to-child transmission of HIV-1. J. Acquir. Immune Defic. Syndr. 35, 169-177.
< , J. T., Ruprecht, R., Ferrantelli, F., Xu, W., Kitabwalla, M., Van Rompay, K., Marthas, M., Haigwood, N., Mascola, J. R., Luzuriaga, K., Jones, S. A., Mathieson, B. J., Newell, M. L. (https://doi.org/10.1097/00126334-200402010-00012>
65. 1999) Control of viraemia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283, 857-860.
< , J. E., Kuroda, M. J., Sasseville, V. G., Simon, M. A., Lifton, M. A., Racz, P., Tenner-Racz, K., Dalesandro, M., Scallon, B. J., Ghrayeb, J., Forman, M. A., Montefiori, D. C., Rieber, E. P., Letvin, N. L., Reinmann, K. A. (https://doi.org/10.1126/science.283.5403.857>
66. 2001) Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants. J. Immunol. 167, 7134-7140.
< , Z. A., Chadwick, E. G., Gibson, L. L., Catalina, M. D., McManus, M. M., Yogev, R., Palumbo, P., Sullivan, J. L., Britto, P., Gay, H., Luzuriaga, K. (https://doi.org/10.4049/jimmunol.167.12.7134>
67. 2000) The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children. J. Infect. Dis. 182, 88-95.
< , H. M., Chandwani, R., Sheehy, M. E., Dobroszycki, J., Fennelly, G., Wiznia, A., Radding, J., Rigaud, M., Pollack, H., Borkowsky, W., Rosenberg, M., Nixon, D. F. (https://doi.org/10.1086/315639>
68. 1999) Lack of infection in HIVexposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response. Proc. Natl. Acad. Sci. USA 96, 1030-1035.
< , S. A., Skurnick, J., Louria, D., Osmond, D., Chang, S. Y., Sninsky, J., Ferrari, G., Weinhold, K., Lindquist, C., Levy, J. A. (https://doi.org/10.1073/pnas.96.3.1030>
69. UNAIDS (2001). AIDS Epidemic Update: December 2001. Geneva, UNAIDS/WHO.
70. 1991) Postnatal transmission of human immunodeficiency virus type 1 from mother to infant. A prospective cohort study in Kigali, Rwanda. N. Engl. J. Med. 325, 593-598.
< , P., Simonon, A., Msellati, P., Hitimana, D. G., Vaira, D., Bazubagira, A., Van Goethem, C., Stevens, A. M., Karita, E., Sondag-Thull, D., et al. (https://doi.org/10.1056/NEJM199108293250901>
71. 2003) Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251. J. Virol. 77, 179-190.
< , K. K., Greenier, J. L., Cole, K. S., Earl, P., Moss, B., Steckbeck, J. D., Pahar, B., Rourke, T., Montelaro, R. C., Canfield, D. R., Tarara, R. P., Miller, C., McChesney, M. B., Marthas, M. L. (https://doi.org/10.1128/JVI.77.1.179-190.2003>
72. 1998) Beta-chemokines are released from HIV-1-specific cytolytic T cell granules complexed to proteoglycans. Nature 391, 908-911.
< , L., Yang, O. O., Garcia-Zepeda, E. A., Ge, Y., Kalams, S. A., Walker, B. D., Pasternack, M. S., Luster, A. D. (https://doi.org/10.1038/36129>
73. 1987) HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 328, 345-348.
< , B. D., Chakrabarti, S., Moss, B., Paradis, T. J., Flynn, T., Durno, A. G., Blumberg, R. S., Kaplan, J. C., Hirsch, M. S., Schooley, R. T. (https://doi.org/10.1038/328345a0>
74. 1997) Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. J. Immunol. 158, 6029-6036.
< , T. J., Jagodzinski, P. P., Hyjek, E. M., Wustner, J., Trinchieri, G., Lischner, H. W., Kozbor, D. (https://doi.org/10.4049/jimmunol.158.12.6029>
75. 2000) Association between HIV-specific T helper responses and CTL activities in pediatric AIDS. Eur. J. Immunol. 30, 117-127.
< , T. J., Wierzbicki, A., Whiteman, V. E., Trinchieri, G., Lischner, H. W., Kozbor, D. (https://doi.org/10.1002/1521-4141(200001)30:1<117::AID-IMMU117>3.0.CO;2-4>
76. 1999) Frequent detection of escape from cytotoxic Tlymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the Ariel Project for the prevention of transmission of HIV from mother to infant. J. Virol. 73, 3975-3985.
< , C. C., Brown, R. C., Korber, B. T., Wilkes, B. M., Ruhl, D. J., Sakamoto, D., Kunstman, K., Luzuriaga, K., Hanson, I. C., Widmayer, S. M., Wiznia, A., Clapp, S., Ammann, A. J., Koup, R. A., Wolinsky, S. M., Walker, B. D. (https://doi.org/10.1128/JVI.73.5.3975-3985.1999>
77. 2002) Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation. J. Virol. 76, 8757-8768.
< , K., Kesmir, C., Gaschen, B., Addo, M. M., Altfeld, M., Brunak, S., Chigaev, A., Detours, V., Korber, B. T. (https://doi.org/10.1128/JVI.76.17.8757-8768.2002>
78. 1998) Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205-2213.
< , A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J., Suresh, M., Altman, J. D., Ahmed, R. (https://doi.org/10.1084/jem.188.12.2205>
79. 1996) Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc. Natl. Acad. Sci. USA 93, 14720-14725.
< , C., Cui, Y., Houston, S., Chang, L. J. (https://doi.org/10.1073/pnas.93.25.14720>
80. 2003) Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. J. Virol. 77, 6108-6116.
< , T., Corey, L., Hwangbo, Y., Lee, J. M., Learn, G. H., Mullins, J. I., McElrath, M. J. (https://doi.org/10.1128/JVI.77.11.6108-6116.2003>
81. 1999) Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection. Clin. Diagn. Lab. Immunol. 6, 718-724.
< , U., Campbell, D., Weinhold, K., Frank, I., Rutstein, R., Starr, S. E. (https://doi.org/10.1128/CDLI.6.5.718-724.1999>