Fol. Biol. 2004, 50, 143-152
https://doi.org/10.14712/fb2004050050143
The Biological Functions of β3 Integrins
References
1. , B. D., Yeager, M. (2002) Three-dimensional model of the human platelet integrin αIIbβ3 based on electron cryomicroscopy and x-ray crystallography. Proc. Natl. Acad. Sci. USA 99, 14059-14064.
<https://doi.org/10.1073/pnas.212498199>
2. , P., Prasad, K. S., Denis, C. V., He, M., Papalia, J. M., Hynes, R. O., Phillips D. R., Wagner D. D. (2002) CD40L stabilizes arterial thrombi by a β3 integrin-dependent mechanism. Nat. Med. 8, 247-252.
<https://doi.org/10.1038/nm0302-247>
3. , M. A., Goodman, S. L., Xiong, J. P. (2002) Coming to grips with integrin binding to ligands. Curr. Opin. Cell Biol. 14, 641-651.
<https://doi.org/10.1016/S0955-0674(02)00371-X>
4. , B. L., Rayburn, H., Crowley, D., Hynes, R. O. (1998) Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell 95, 507-519.
<https://doi.org/10.1016/S0092-8674(00)81618-9>
5. , R. B., French, D. L., Vilaire, G., Brown, D. L., Chen, F., Coller, B. S., Derrick, J. M., Gartner, T. K., Bennet, J. S., Poncz M. (2000) A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3. Blood 95, 180-188.
<https://doi.org/10.1182/blood.V95.1.180>
6. , S., Caen, J. (2002) Molecular basis of Glanzmannís Thrombasthenia and current strategies in treatment. Blood Rev. 16, 193-202.
<https://doi.org/10.1016/S0268-960X(02)00030-9>
7. , J. S. (2001) Novel platelet inhibitors. Annu. Rev. Med. 52, 161-184.
<https://doi.org/10.1146/annurev.med.52.1.161>
8. , A., Roivainen, M., Hovi, T., Mason, P. W., Baxt, B. (1995) Antibodies to the vitronectin receptor (integrin αVβ3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells. J. Virol. 69, 2664-2666.
<https://doi.org/10.1128/jvi.69.4.2664-2666.1995>
9. , S. E., Tybjaerg-Hansen, A., Nordestgaard, B. G. (2003) Integrin β3 Leu33Pro homozygosity and risk of cancer. J. Natl. Cancer Inst. 95, 1150-1157.
<https://doi.org/10.1093/jnci/djg005>
10. , H., Benchaibi, M., Berthier-Vergnes, O., Lizard, G., Bailly, M., McGregor, J. L. (1994) Two human melanoma cell-line variants with enhanced in vivo tumor growth and metastatic capacity do not express the β3 integrin subunit. Eur. J. Biochem. 220, 485-491.
<https://doi.org/10.1111/j.1432-1033.1994.tb18647.x>
11. , K., Henn, V., Grafe, M., de Boer, O. J., Becker, A. E., Kroczek, R. A. (2003) CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40CD40L signalling in atherosclerosis. J. Pathol. 201, 288-295.
<https://doi.org/10.1002/path.1425>
12. , G. F., Cosgrove, L., Triglia, T., Beall, J. A., Lopez, A. F., Werkmeister, J. A., Begley, C. G., Haddad, A. P., díApice, A. J. F., Vadas, M. A., Cawley, J. C. (1986) The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Cell 45, 269-280.
<https://doi.org/10.1016/0092-8674(86)90391-0>
13. , R. C., Koch, K. A., Oegema, T. R. Jr., Skubitz, K. M., Pambuccian, S. E., Grindle, S. M., Skubitz, A. P. (2003) Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers. Clin. Exp. Metastasis 20, 343-356.
<https://doi.org/10.1023/A:1024009131191>
14. , H. C., Appeddu, P. A., Parsons, J. T., Hildebrand, J. D., Schaller, M. D., Guan, J. L. (1995) Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem. 270, 16995-16999.
<https://doi.org/10.1074/jbc.270.28.16995>
15. , H. C., Appeddu, P. A., Isoda, H., Guan, J. L. (1996) Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J. Biol. Chem. 271, 26329-26334.
<https://doi.org/10.1074/jbc.271.42.26329>
16. , Y. Q., Trikha, M., Gao, X., Bazaz, R., Porter, A. T., Timar, J., Honn, K. V. (1997) Ectopic expression of platelet integrin αIIbβ3 in tumor cells from various species and histological origin. Int. J. Cancer 72, 642-648.
<https://doi.org/10.1002/(SICI)1097-0215(19970807)72:4<642::AID-IJC16>3.0.CO;2-D>
17. , S. L., Lai, C. F., Fausto, A., Chellaiah, M., Feng, X., McHugh, K. P., Teitelbaum, S. L., Civitelli, R., Hruska, K. A., Ross, F. P., Avioli, L. V. (2000) Regulation of αvβ3 and αvβ5 integrins by dexamethasone in normal human osteoblastic cells. J. Cell Biochem. 7, 265-276.
<https://doi.org/10.1002/(SICI)1097-4644(20000501)77:2<265::AID-JCB9>3.0.CO;2-6>
18. , F., Ferri, C., Desderi, G., Paloscia, L., Materazzo, G., Mascellanti, M., Fazia, M., Iezzi, A., Cuccurullo, C., Pini, B., Bucci, M., Santucci, A., Cuccurullo, F., Mezzetti, A. (2003) Preprocedural level of soluble CD40L is predicVol. 50 tive of enhanced inflammatory response and restenosis after coronary angioplasty. Circulation 108, 2776-2782.
<https://doi.org/10.1161/01.CIR.0000103700.05109.0D>
19. , B. S., Londrigan, S. L., Lee, D. J. (1997) Rotavirus contains integrin ligand sequences and a disintegrin-like domain that are implicated in virus entry into cells. Proc. Natl. Acad. Sci. USA 94, 5389-5394.
<https://doi.org/10.1073/pnas.94.10.5389>
20. , E. H., Jansen, K. F., Van Kraats, A. A., Cornelissen, I. M., Ruiter, D. J., Van Muijen, G. N. (1995) Alpha v-integrins in human melanoma: gain of αvβ3 and loss of αvβ5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice. Int. J. Cancer 61, 491-496.
<https://doi.org/10.1002/ijc.2910610411>
21. , S., Katz, J. A., Saibeni, S., Papa, A., Gasbarrini, A., Vecchi, M., Fiocchi, C. (2003) Activated platelets are the source of elevated levels of soluble CD40L in the circulation of inflammatory bowel disease patients. Gut 52, 1435-1441.
<https://doi.org/10.1136/gut.52.10.1435>
22. , H., Baxt, B. (2003) Foot-and-mouth disease virus receptors: comparison of bovine αv integrin utilization by type A and O viruses. J. Virol. 77, 2500-2511.
<https://doi.org/10.1128/JVI.77.4.2500-2511.2003>
23. , B., Mueller, B. M., Romerdahl, C. A., Cheresh, D. A. (1992) Involvement of integrin αV gene expression in human melanoma tumorigenicity. J. Clin. Invest. 89, 2018-2022.
<https://doi.org/10.1172/JCI115811>
24. , I. N., Brown, E. J., Ginsberg, M. H., Mackow, E. R. (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by β3 integrins. J. Virol. 73, 3951-3959.
<https://doi.org/10.1128/JVI.73.5.3951-3959.1999>
25. , K., Kulkarni, B., Nair, S., Shetty, S., Mohanty, D. (2002) Human platelet alloantigen polymorphism in Glanzmannís thrombasthenia and its impact on the severity of the disease. Br. J. Haematol. 119, 348-353.
<https://doi.org/10.1046/j.1365-2141.2002.03864.x>
26. , F. G., Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032.
<https://doi.org/10.1126/science.285.5430.1028>
27. , A., Dabrowska, K., Switala-Jelen, K., Nowaczyk, M., Weber-Dabrowska, B., Boratynski, J., Wietrzyk, J., Opolski, A. (2003a) New insights into the possible role of bacteriophages in host defense and disease. Med. Immunol. 2, 2.
<https://doi.org/10.1186/1476-9433-2-2>
28. , A., Nowaczyk, M., Weber-Dabrowska, B., Kniotek, M., Boratynski, J., Ahmed, A., Dabrowska K, Wierzbicki P, Switala-Jelen K, Opolski A. (2003b) New insights into the possible role of bacteriophages in transplantation. Transplant. Proc. 35, 2372-2373.
<https://doi.org/10.1016/S0041-1345(03)00811-X>
29. , J. L., Shalloway, D. (1992) Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692.
<https://doi.org/10.1038/358690a0>
30. , C. A., Mendez, E., Zarate, S., Isa, P., Lopez, S., Arias, C. F. (2000) Integrin αvβ3 mediates rotavirus cell entry. Proc. Natl. Acad. Sci. USA 97, 14644-14649.
<https://doi.org/10.1073/pnas.250299897>
31. , T. A., Plow, E. F. (1994) Integrin-ligand interactions: a year in review. Curr. Opin. Cell Biol. 6, 656-662.
<https://doi.org/10.1016/0955-0674(94)90091-4>
32. , P. J., Ruminski, P. G., Rico, J. G., Lu, H. S., Griggs, D. W. (2002) Adenovirus inhibition by peptidomimetic integrin antagonists. Antiviral Res. 55, 169-178.
<https://doi.org/10.1016/S0166-3542(02)00021-9>
33. , K. M., McHugh, K. P., Tsakiris, D. A., Rayburn, H., Crowley, D., Ullman-Cullere, M., Ross, F. P., Coller, B. S., Teitelbaum, S., Hynes, R. O. (1999) β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103, 229-238.
<https://doi.org/10.1172/JCI5487>
34. , S. Y., Lee, H., You, W. K., Chung, K. H., Kim, D. S., Song, K. (2003) The snake venom disintegrin salmosin induces apoptosis by disassembly of focal adhesions in bovine capillary endothelial cells. Biochem. Biophys. Res. Commun. 302, 502-508.
<https://doi.org/10.1016/S0006-291X(03)00213-4>
35. , R., Kawaguchi, M., Masui, T., Koshiba, T., Ida, J., Fujimoto, K., Wada, M., Doi, R., Imamura, M. (2002) Expression of integrin αvβ3 in pancreatic carcinoma: relation to MMP-2 activation and lymph node metastasis. Pancreas 25, e30-35.
<https://doi.org/10.1097/00006676-200208000-00021>
36. , M. J. (2000) Integrin structure. Biochem. Soc. Trans. 28, 311-339.
<https://doi.org/10.1042/bst0280311>
37. , T., Horsnell, C., Maaronen, M., Khan, M., Kalkkinen, N., Auvinen, P., Kinnunen, L., Stanway, G. (1992) A distinct picornavirus group identified by sequence analysis. Proc. Natl. Acad. Sci. USA 89, 8847-8851.
<https://doi.org/10.1073/pnas.89.18.8847>
38. , T., Blakemore, W., Newman, J. W., Knowles, N. J., Mould, A. P., Humphries, M. J., King, A. M. (2000a) Footand-mouth disease virus is a ligand for the high-affinity binding conformation of integrin α5β1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding. J. Gen. Virol. 81, 1383-1391.
39. , T., Sheppard, D., Denyer, M., Blakemore, W., King, A. M. (2000b) The epithelial integrin αvβ6 is a receptor for foot-and-mouth disease virus. J. Virol. 74, 4949-4956.
<https://doi.org/10.1128/JVI.74.11.4949-4956.2000>
40. , I. C., Chung, K. H., Lee, S. J., Yun, Y., Moon, H. M., Kim, D. S. (1998) Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb. Res. 91, 65-73.
<https://doi.org/10.1016/S0049-3848(98)00053-X>
41. , I. C., Lee, Y. D., Kim, D. S. (1999) A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 59, 3754-3760.
42. , R., Ishikawa, T., Kamiya, S., Oguma, F., Ueki, M., Goto, S., Nakamura H, Katayama, T, Fukai, F. (2002) A new type of antimetastatic peptide derived from fibronectin. Clin. Cancer Res. 8, 2455-2462.
43. , R., Veerapandian, B., Kunicki, T. J., Ely, K. R. (1995) Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site. J. Biol. Chem. 270, 2268-2273.
<https://doi.org/10.1074/jbc.270.5.2268>
44. , S., Diefenbach, B., Mehta, R., Jonczyk, A., Luckenbach, G. A., Goodman, S. L. (1999) Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J. Biol. Chem. 274, 1979-1985.
<https://doi.org/10.1074/jbc.274.4.1979>
45. , R. M., Lee, S. F., Hewlett, I. K., Yamada, K. M., Dhawan, S. (2002) Involvement of integrin alphavbeta3 in the pathogenesis of human immunodeficiency virus type 1 infection in monocytes. Virology 297, 31-38.
<https://doi.org/10.1006/viro.2002.1399>
46. , S. J., Lam, S. C., Lau, L. F. (2002) Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J. Biol. Chem. 277, 46248-46255.
<https://doi.org/10.1074/jbc.M209288200>
47. , R., Hoess, R. H., Bennett, J. S., DeGrado, W. F. (2003) Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 16, 65-72.
<https://doi.org/10.1093/proeng/gzg002>
48. , X., Regezi, J., Ross, F. P., Blystone, S., Ilic, D., Leong, S. P., Ramos, D. M. (2001) Integrin αvβ3 mediates K1735 murine melanoma cell motility in vivo and in vitro. J. Cell Sci. 114, 2665-2672.
<https://doi.org/10.1242/jcs.114.14.2665>
49. , W. L., Longley, R. L., Brassard, D. L., Armstrong, L., Schaefer, E. J. (2002) Role of integrin alphaVbeta3 in the production of recombinant adenoviruses in HEK-293 cells. Gene Ther. 9, 907-914.
<https://doi.org/10.1038/sj.gt.3301726>
50. , J. F., Hart, I. R. (1996) The role of alpha v-integrins in tumour progression and metastasis. Semin. Cancer Biol. 7, 129-138.
<https://doi.org/10.1006/scbi.1996.0018>
51. , K. P., Hodivala-Dilke, K., Zheng, M. H., Namba, N., Lam, J., Novack, D., Xu, F., Ross, F. P., Hynes, R. O., Teitelbaum, S. L., (2000) Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest. 105, 433-440.
<https://doi.org/10.1172/JCI8905>
52. , K., Kumagai, H., Masuda, T., Kawada, M., Ishizuka, M., Takeuchi, T. (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int. J. Cancer 93, 307-316.
<https://doi.org/10.1002/ijc.1321>
53. , J. S., Kanca, O., McIntyre, B. W. (2002) Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. J. Immunol. 168, 2737-2744.
<https://doi.org/10.4049/jimmunol.168.6.2737>
54. , W. B., Li, J. H., Singh, F., Michelson, A. D., Bussel, J., Coller, B. S., French, D. L. (2003) Two novel mutations in the αIIb calcium-binding domains identify hydrophobic regions essential for αIIbβ3 biogenesis. Blood 101, 2268-2276.
<https://doi.org/10.1182/blood-2002-07-2266>
55. , G. J. (1999) Role of integrins in cancer: survey of expression patterns. Proc. Soc. Exp. Biol. Med. 222, 124-138.
<https://doi.org/10.1046/j.1525-1373.1999.d01-122.x>
56. , J. O., Kim, J. E., Jeong, H. W., Lee, S. J., Lee, B. H., Choi, J. Y., Park, R. W., Park, J. Y., Kim, I. S. (2003) Identification of the αvβ3 integrin-interacting motif of βig-h3 and its anti-angiogenic effect. J. Biol. Chem. 278, 25902-25909.
<https://doi.org/10.1074/jbc.M300358200>
57. , B., Eggers, H. J., Zimmermann, H. (1999) Integrin αvβ3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain Barty. J. Gen. Virol. 80, 2311-2313.
<https://doi.org/10.1099/0022-1317-80-9-2311>
58. , J. A., Cher, M. L., Zhou, Z., Mullins, C., Bhagat, S., Trikha, M. (2003) Inhibition of αvβ3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases. Clin. Exp. Metastasis 20, 413-420.
<https://doi.org/10.1023/A:1025461507027>
59. , S., McLane, M. A., Kloczewiak, M., Stewart, G. J. (1994) Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Semin. Hematol. 31, 289-300.
60. , E., Tsopanoglou, N. E., Andriopoulou, P., Maragoudakis, M. E. (2002) On the mechanism of thrombin-induced angiogenesis: involvement of αvβ3-integrin. Am. J. Physiol. Cell Physiol. 283, 1501-1510.
61. , L., Mrowiec, Z., Schwartz, E., Khorshidi, M., Dutcher, J. P., Puszkin, E. (1995) Characterization of tumor-induced platelet aggregation: the role of immunorelated GPIb and GPIIb/IIIa expression by MCF-7 breast cancer cells. Thromb. Res. 79, 261-274.
<https://doi.org/10.1016/0049-3848(95)00113-6>
62. , E. F., Haas, T. A., Zhang, L., Loftus, J., Smith, J. W. (2000) Ligand binding to integrins. J. Biol. Chem. 275, 21785-21788.
<https://doi.org/10.1074/jbc.R000003200>
63. , K. S., Andre, P., Yan, Y., Phillips, D. R. (2003) The platelet CD40L, GPIIb-IIIa axis in atherothrombotic disease. Curr. Opin. Hematol. 10, 356-361.
<https://doi.org/10.1097/00062752-200309000-00006>
64. , T., Koivunen, E., Hyypia, T. (1997) Cell-surface interactions of echovirus 22. J. Biol. Chem. 272, 21176-21180.
<https://doi.org/10.1074/jbc.272.34.21176>
65. , A., Tseng, Y., Wirtz, D. (2002) Micromechanical coupling between cell surface receptors and RGD peptides. Biochem. Biophys. Res. Commun. 296, 771-778.
<https://doi.org/10.1016/S0006-291X(02)00903-8>
66. , M. E., Sho, M., Robertson, S. W., Geehan, C. S., Briscoe, D. M. (2003) Proangiogenic function of CD40LCD40 interaction. J. Immunol. 171, 1534-1541.
<https://doi.org/10.4049/jimmunol.171.3.1534>
67. , M., Piirainen, L., Hovi, T., Virtanen, I., Riikonen, T., Heino, J., Hyypia, T. (1994) Entry of coxsackievirus A9 into host cells: specific interactions with αvβ3 integrin, the vitronectin receptor. Virology 203, 357-365.
<https://doi.org/10.1006/viro.1994.1494>
68. , S. A., Zutter, M. M. (1995) The α2β1 integrin: a collagen receptor on platelets and other cells. Thromb. Haemost. 74, 813-821.
69. , T., Miwa, A. (2002) Ets-1 and integrin β3 for lung metastasis from colorectal cancer. APMIS 110, 347-353.
<https://doi.org/10.1034/j.1600-0463.2002.100410.x>
70. , D. D., Hanks, S. K., Hunter, T., van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
<https://doi.org/10.1038/372786a0>
71. , M., Vuori, K., Ruoslahti, E. (1997) αvβ3 integrin associates with activated insulin and PDGFβ receptors and potentiates the biological activity of PDGF. EMBO J. 16, 5600-5607.
<https://doi.org/10.1093/emboj/16.18.5600>
72. , M. A., Schaller, M. D., Ginsberg, M. H. (1995) Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11, 549-599.
<https://doi.org/10.1146/annurev.cb.11.110195.003001>
73. , R. E. (1998) Role of the β3 integrin subunit in human primary melanoma progression: multifunctional activities associated with αvβ3 integrin expression. Am. J. Pathol. 153, 1347-1351.
<https://doi.org/10.1016/S0002-9440(10)65719-7>
74. , R. E., Seftor, E. A., Stetler-Stevenson, W. G., Hendrix, M. J. (1993) The 72 kDa type IV collagenase is modulated via differential expression of αvβ3 and α5β1 integrins during human melanoma cell invasion. Cancer Res. 53, 3411-3415.
75. , D. (2000) In vivo functions of integrins: lessons from null mutations in mice. Matrix Biol. 19, 203-209.
<https://doi.org/10.1016/S0945-053X(00)00065-2>
76. , M., Springer, T. A. (2003) Therapeutic antagonists and conformational regulation of integrin function. Nat. Rev. Drug Discov. 2, 703-716.
<https://doi.org/10.1038/nrd1174>
77. , R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G., Bussolino, F. (1999) Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18, 882-892.
<https://doi.org/10.1093/emboj/18.4.882>
78. , T., Knudsen, K. A., Beviglia, L., Rossi, C., Poggi, A., Niewiarowski, S. (1991) Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, an RGD-containing peptide isolated from the venom of Trimeresurus albolabris. Exp. Cell Res. 196, 6-12.
<https://doi.org/10.1016/0014-4827(91)90449-5>
79. , J., Trikha, M., Szekeres, K., Bazaz, R., Honn, K. (1998) Expression and function of the high affinity αIIbβ3 integrin in murine melanoma cells. Clin. Exp. Metastasis 16, 437-445.
<https://doi.org/10.1023/A:1006533508560>
80. , J., Trikha, M., Szekeres, K., Bazaz, R., Tovari, J., Silletti, S., Raz, A., Honn, K. V. (1996) Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion. Cancer Res. 56, 1902-1908.
81. , E. C., Baker, E. K., Ginsberg, M. H., Loftus, J. C. (1999) A mutation in the α subunit of the platelet αIIbβ3 identifies a novel region important for ligand binding. Blood 93, 918-924.
<https://doi.org/10.1182/blood.V93.3.918>
82. , M., Triantafilou, K., Wilson, K. M., Takada, Y., Fernandez, N. (1999) Involvement of β 2-microglobulin and integrin αvβ 3 molecules in the coxackievirus A9 infectious cycle. J. Gen. Virol. 80, 2591-2606.
<https://doi.org/10.1099/0022-1317-80-10-2591>
83. , K., Triantafilou, M., Takada, Y., Fernandez, N. (2000) Human parechovirus 1 utilizes integrins αvβ3and αvβ1 as receptors. J. Virol. 261, 110-111.
84. , K., Takada, Y., Triantafilou, M. (2001) Mechanisms of integrin-mediated virus attachment and internalization process. Crit. Rev. Immunol. 21, 311-322.
<https://doi.org/10.1615/CritRevImmunol.v21.i4.10>
85. , M., Timar, J., Lundy, S. K., Szekeres, K., Tang, K., Grignon, D., Porter, A. T., Honn, K. V. (1996) Human prostate carcinoma cells express functional αIIbβ3 integrin. Cancer Res. 56, 5071-5078.
86. , M., Timar, J., Zacharek, A., Nemeth, J. A., Cai, Y., Dome, B., Somlai, B., Raso, E., Ladanyi, A., Honn, K. V. (2002) Role for β3 integrins in human melanoma growth and survival. Int. J. Cancer 101, 156-167.
<https://doi.org/10.1002/ijc.10521>
87. , G. C. (2003) αv integrin inhibitors and cancer therapy. Curr. Opin. Investig. Drugs 4, 722-731.
88. , N., de Lemos, J. A., Libby, P. Morrow, D. A., Murphym, S. A., Nuzzo, R., Gibson, C. M., Cannon, C. P., Braunwald, E., Schonbeck, U. (2003) Soluble CD40L: risk prediction after acute coronary syndromes. Circulation 108, 1049-1052.
<https://doi.org/10.1161/01.CIR.0000088521.04017.13>
89. , H. M., Jorna, A. S., Hoekman, K., Broxterman, H. J., Gebbink, M. F., Pinedo, H. M. (2000) Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets. Blood 96, 4216-4221.
<https://doi.org/10.1182/blood.V96.13.4216>
90. , O., Velyvis, A., Velyveiene, A., Hu, B., Haas, T. A., Plow, E. F., et al. (2002) A structural mechanism of integrin αIIbβ 3 ìinside-outî activation as regulated by its cytoplasmic face. Cell 110, 587-597.
<https://doi.org/10.1016/S0092-8674(02)00906-6>
91. , H. (2003) The new immunosuppression: just kill the T cell. Nat. Med. 9, 1259-1260.
<https://doi.org/10.1038/nm1003-1259>
92. , K. K., Mainiero, F., Isakoff, S. J., Marcantonio, E. E., Giancotti, F. G. (1996) The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 733-743.
<https://doi.org/10.1016/S0092-8674(00)81392-6>
93. , T. J., Mathias, P., Cheresh, D. A., Nemerow, G. R. (1993) Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 73, 309-319.
<https://doi.org/10.1016/0092-8674(93)90231-E>
94. , A. S., Garcia-Cardena, G., Leong, M., Madri, J. A., Sessa, W. C., Languino, L. R. (1998) The synergistic activity of αvβ3 integrin and PDGF receptor increases cell migration. J. Cell Sci. 111, 469-478.
<https://doi.org/10.1242/jcs.111.4.469>
95. , J. P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., Arnaout, M. A. (2001) Crystal structure of the extracellular segment of integrin αvβ3. Science 294, 339-345.
<https://doi.org/10.1126/science.1064535>
96. , M. H., Masri, C. S., Ratcliff, N. B., Bond, M., Starling, R. C., Tuzcu, E. M., McCarthy, P. M., Young, J. B. (2002a) The role of vitronectin receptor (alphavbeta3) and tissue factor in the pathogenesis of transplant coronary vasculopathy. J. Am. Coll. Cardiol. 39, 804-810.
<https://doi.org/10.1016/S0735-1097(01)01823-X>
97. , M. H., Yang, J., Masri, C. S., Ratcliff, N. B., Bond, M., Starling, R. C., McCarthy, P., Plow, E., Young, J. B. (2002b) Acute cellular rejection following human heart transplantation is associated with increased expression of vitronectin receptor (integrin αvβ3). Am. J. Transpl. 2, 129-133.
<https://doi.org/10.1034/j.1600-6143.2002.020203.x>
98. , C. H., Peng, H. C., Huang, T. F. (1998) Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin αvβ3 antagonist and inducing apoptosis. Blood 92, 3268-3276.
<https://doi.org/10.1182/blood.V92.9.3268>
99. , C. H., Peng, H. C., Yang, R. S., Huang, T. F. (2001) Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective αvβ3 blockade of endothelial cells. Mol. Pharmacol. 59, 1333-1342.
<https://doi.org/10.1016/S0026-895X(24)12595-3>
100. , H., Eggers, H. J., Nelsen-Salz, C. (1997) Cell attachment and mouse virulence of Echovirus 9 correlate with an RGD motif in the capsid protein VP1. Virology 233, 149-156.
<https://doi.org/10.1006/viro.1997.8601>
