Fol. Biol. 2004, 50, 153-156
https://doi.org/10.14712/fb2004050050153
The Frequency of Alleles of the Pro12Ala Polymorphism in PPARγ2 Is Different between Healthy Controls and Patients with Type 2 Diabetes
References
1. 2000) The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26, 76-80.
< , D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M. C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., Tuomi, T., Gaudet, D., Hudson, T. J., Daly, M., Groop, L., Lander, E. S. (https://doi.org/10.1038/79216>
2. 2000) The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int. J. Obes. Relat. Metab. Disord. 24, 391-393.
< , K., Hercberg, S., Passinge, B., Galan, P., VarroudVial, M., Shuldiner, A. R., Beamer, B. A., Charpentier, G., Guy-Grand, B., Froguel, P., Vaisse, C. (https://doi.org/10.1038/sj.ijo.0801191>
3. 2001) The pleiotropic functions of peroxisome proliferator-activated receptor γ. J. Mol. Med. 79, 30-47.
< , M. B., Renaud, J. P. (https://doi.org/10.1007/s001090000145>
4. 1998) Pro12Ala substitution in PPAR γ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 20, 284-287.
< , S. S., Fajas, L., Nemoto, M., Pihlajam‰ki, J., Mykk‰nen, L., Kuusisto, J., Laakso, M., Fujimoto, W., Auwerx, J. A. (https://doi.org/10.1038/3099>
5. 2000) The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes. Biochem. Biophys. Res. Commun. 271, 212-216.
< , K., Okada, T., Tobe, K., Yasuda, K., Mori, Y., Kadowaki, H., Hagura, R., Akanuma, Y., Kimura, S., Ito, C., Kadowaki, T. (https://doi.org/10.1006/bbrc.2000.2605>
6. 2000) The PPAR gamma2 polymorphism Pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients. Horm. Metab. Res. 32, 413-416.
< , S., Stumvoll, M., Becker, R., Koch, M., Nielsen, M., Loblein, K., Maerker, E., Volk, A., Renn, W., Balletshofer, B., Machicao, F., Rett, K., Haring, H. U. (https://doi.org/10.1055/s-2007-978663>
7. 1999) The PPAR γ2 amino acid polymorphism Pro12Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in subgroup of obese subjects. Diabetologia 42, 758-762.
< , M., Rett, K., Maerker, E., Volk, A., Haist, K., Deninger, M., Renn, W., H‰ring, H. U. (https://doi.org/10.1007/s001250051225>
8. 1999) Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes. Diabetes 48, 1466-1468.
< , F. P., Vaccaro, O., Sabatino, L., Tufano, A., Rivellese, A. A., Riccardi, G., Colantuoni, V. (https://doi.org/10.2337/diabetes.48.7.1466>
9. 1998) Effect of the Pro12Ala variant of the human peroxisome proliferatoractivated receptor γ2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men. Biochem. Biophys. Res. Commun. 251, 195-198.
< , Y., Kim-Motoyama, H., Katakura, T., Yasuda, K., Kadowaki, H., Beamer, B. A., Shuldiner, A. R., Akanuma,Y., Yazaki, Y., Kadowaki, T. (https://doi.org/10.1006/bbrc.1998.9421>
10. 2001) The Pro12Ala substitution is associated with resistance to development of diabetes in the general population. Diabetes 5, 891-894.
< , H., Ikegami, H., Kawaguchi, Y., Seino, S., Yokoi, N., Takeda, J., Inoue, I., Seino, Y., Yasuda, K., Hanafusa, T., Yamagata, K., Awata, T., Kadowaki, T., Hara, K., Yamada, N., Gotoda, T., Iwasaki, N., Iwasaki, N., Sanke, T., Nanjo, K., Oka, Y., Matsutani, A., Maeda, E., Kasuga, M. (https://doi.org/10.2337/diabetes.50.4.891>
11. 1999) Pro12Ala missense mutation of the peroxisome proliferator activated receptor γ and diabetes mellitus. Biochem. Biophys. Res. Commun. 254, 450-453.
< , J., Engeli, S., Distler, A., Sharma, A. M. (https://doi.org/10.1006/bbrc.1998.9962>
12. 2001) Gene PPARγ arouses interest of obesitologists and diabetologists. Diabetology, Metabolism, Endocrinology, Nutrition 4, 278-286.
, D., Kunešová, M., Hainer, V., Bendlová, B. (
13. 1997) Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem. Biophys. Res. Commun. 241, 270-274.
< , C. J., Beamer, B. A., Negri, C., Silver, K., Brown, K. A., Yarnall, D. P., Burns, D. K., Roth, J., Shuldiner, A. R. (https://doi.org/10.1006/bbrc.1997.7798>
14. 2002) Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 (PPARγ2) is associated with higher levels of total cholesterol and LDLcholesterol in male caucasian type 2 diabetes patients. Exp. Clin. Endocrinol. Diabetes 110, 60-66.
< , B., Barth, N., Spielgel, D., Schmitz, G., Schölmerich, J., Schäffler, A. (https://doi.org/10.1055/s-2002-23487>