Fol. Biol. 2004, 50, 157-158
https://doi.org/10.14712/fb2004050050157
A Gly482Ser Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1) Gene Is Associated with Type 2 Diabetes in Caucasians
References
1. , I., Luan, J., Middelberg, R. P., Harding, A. H., Franks, P. W., Jakes, R. W., Clayton, D., Schafer, A. J., O'Rahilly, S., Wareham, N. J. (2003) Candidate gene association study in type 2 diabetes indicates a role for genes involved in β-cell function as well as insulin action. PLoS Biol. 1, 041-055.
2. , J., Andersen, G., Urhammer, S. A., Gaede, P. H., Drivsholm, T., Borch-Johnsen, K., Hansen, T., Pedersen, O. (2001) Mutation analysis of peroxisome proliferatoractivated receptor-γ coactivator-1 and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 44, 2220-2226.
<https://doi.org/10.1007/s001250100032>
3. , H., Oberkofler, H., Linnemayr, V., Iglseder, B., Hedegger, M., Wolfsgruber, P., Paulweber, B., Fastner, G., Krempler, F., Patsch, W. (2002) Peroxisome proliferatoractivated receptor-γ coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes 51, 1281-1286.
<https://doi.org/10.2337/diabetes.51.4.1281>
4. , K., Tobe, K., Okada, T., Kadowaki, H., Akanuma, Y., Ito, C., Kimura, S., Kadowaki, T. (2002) A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 45, 740-743.
<https://doi.org/10.1007/s00125-002-0803-z>
5. , C., Chikri, M., Boutin, P., Samson, C., Froguel, P. (2002) No association between the G482S polymorphism of the proliferator-activated receptor-γ coactivator-1 gene and Type II diabetes in French Caucasias. Diabetologia 45, 602-603.
<https://doi.org/10.1007/s00125-002-0783-z>
6. , Y. L., Bogardus, C., Pedersen, O., Baier, L. (2003) A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor-γ coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes 52, 895-898.
<https://doi.org/10.2337/diabetes.52.3.895>
7. , H., Groop, L. (2004) Candidate genes for type 2 diabetes. Rev. Endocr. Metab. Disord. 5, 151-176.
<https://doi.org/10.1023/B:REMD.0000021437.46773.26>
8. , R. E., Thompson, D. B., Prochazka, M., Baier, L., Mott, D., Ravussin, E., Sakul, H., Ehm, M. G., Burns, D. K., Foroud, T., Garvey, W. T., Hanson, R. L., Knowler, W. C., Bennett, P. H., Bogardus, C. (1998) An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J. Clin. Invest. 101, 1757-1764.
<https://doi.org/10.1172/JCI1850>
