Fol. Biol. 2004, 50, 200-202
The Role of NK1.1+ Cells in the Protection against MHC Class I+ HPV16-Associated Tumours
Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation or on the day of transplantation substantially accelerated tumour growth; depletion starting on day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a "missing self" signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of nonNK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results.
Keywords
Funding
This work was supported by grants Nos. IAA50522203 and K5011112 from the Grant Agency of the Academy of Sciences of the Czech Republic; Nos. NC/7148 and NR/7807-3 from the Grant Agency of the Ministry of Health of the Czech Republic and by the League Against Cancer, Prague.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.