Cytogenetic Investigation of Workers Professionally Exposed to Phosphates and Their Derivatives

Glouib, K.; Verschaeve, L.; Naber, N.; Hilali, Abdelilah

doi:10.14712/fb2005051060166

Fol. Biol. 2005, 51, 166-171

https://doi.org/10.14712/fb2005051060166

Cytogenetic Investigation of Workers Professionally Exposed to Phosphates and Their Derivatives

K. Glouib¹, L. Verschaeve², N. Naber³, Abdelilah Hilali¹

¹Laboratory of Cytogenetics and Toxicogenetics, Hassan 1 University, Faculty of Sciences and Technics, Settat, Morocco
²VITO, Expertise Centre of Environmental Toxicology, Mol, Belgium
³Laboratory of Anthropogenetics, UCD, Faculty of Sciences, El Jadida, Morocco

Received July 2005
Accepted August 2005

The phosphor industry in Morocco employs a great number of workers that may be exposed to this essential but also toxic compound. In the present investigation, professionally exposed subjects from two different production lines (miners and production unit workers) were investigated for the presence of genetic damage in their peripheral blood lymphocytes. This was done with the well-known micronucleus assay. The proliferation and mitotic indices were also investigated. It was found that the micronucleus frequency was considerably increased compared to the frequency in non-exposed control subjects. Mitotic and proliferation indices were not increased, at least not in a statistically significant way. At the time being this investigation should be considered as a preliminary study in which the influence of potential confounders cannot be adequately assessed. However, our results are non-equivocal and clearly indicate a potential health risk in these workers.