Fol. Biol. 2005, 51, 198-203
https://doi.org/10.14712/fb2005051060198
Toll-like Receptors. III. Biological Significance and Impact for Human Medicine
References
1. 2000) Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer. Cytokines Cell Mol. Ther. 6, 171-176.
< , S. S., Kirkwood, J. M., Bryant, J. (https://doi.org/10.1080/mccm.6.4.171.176>
2. 2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680.
< , S., Takeda, K., Kaisho, T. (https://doi.org/10.1038/90609>
3. 2000) CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms. J. Immunol. 165, 6889-6895.
< , D., Chu, R. S., Krieg, A. M., Harding, C. V. (https://doi.org/10.4049/jimmunol.165.12.6889>
4. 2002) Activation of Paneth cell alpha-defensins in mouse small intestine. J. Biol. Chem. 277, 5219-5228.
< , T., Satchell, D. P., Pesendorfer, P., Tanabe, H., Wilson, C. L., Hagen, S. J., Ouellette, A. J. (https://doi.org/10.1074/jbc.M109410200>
5. 2004) The emerging role of interferon in human systemic lupus. Curr. Opin. Immunol. 18, 801-807.
< , E. C., Gregersen, P. K., Behrens, T. W. (https://doi.org/10.1016/j.coi.2004.09.014>
6. 2002) Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1 J. Biol. Chem. 277, 8048-8453.
< , D. D., Tupper, J. C., Erwert, R. D., Winn, R. K., Harlan, J. M. (https://doi.org/10.1074/jbc.M111249200>
7. 2001) Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment. J. Infect. Dis. 183, 844-849.
< , D. I., Harrison, C. J., Tomai, M. A., Miller, R. L. (https://doi.org/10.1086/319262>
8. 2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294, 1540-1543.
< , P., Palucka, A. K., Gill, M., Pascual, V., Banchereau, J. (https://doi.org/10.1126/science.1064890>
9. 2002) T cell polarisation and role ofcytokines in induction of autoimmunity processes. Rheumatol. 16, 117-124.
, M. (
10. 1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5, 919-923.
< , M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. (https://doi.org/10.1038/11360>
11. 2004) Direct bacterial protein PAMPs recognition by human NK cells involves TLRs and triggers {alpha}-defensin production. Blood 104, 1778-1783.
< , A., Jeannin, P., Gauchat, J. F., Blaecke, A., Malissard, M., N'Guyen, T., Thieblemont, N., Delneste, Y. (https://doi.org/10.1182/blood-2003-08-2820>
12. 1998) Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathway. J. Biol. Chem. 273, 20185-20188.
< , K. B., Wong, F., Harlan, J. M., Chaudhary, P. M., Hood, L., Karsan, A. (https://doi.org/10.1074/jbc.273.32.20185>
13. 2003) Human beta-defensins and Toll-like receptors in the upper airway. Allergy 58, 748-753.
< , S., de Belder, T., Holtappels, G., Gevaert, P., Verhasselt, B., van Cauwenberge, P., Bachert, C. (https://doi.org/10.1034/j.1398-9995.2003.00180.x>
14. 2005) The Yin and Yang of type I interferon activity in bacterial infection. Nat. Rev. Immunol. 5, 675-687.
< , T., Müller, M., Stockinger, S. (https://doi.org/10.1038/nri1684>
15. 2003) The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner. J. Biol. Chem. 278, 46252-46260.
< , P. L., Ram, S., Andersen, J. M., Guo, W., Ingalls, R. R. (https://doi.org/10.1074/jbc.M306587200>
16. 2001) Reduction of recurrent HSV disease using imiquimod alone or combined with a glycoprotein vaccine. Vaccine 19, 1820-1826.
< , C. J., Miller, R. L., Bernstein, D. I. (https://doi.org/10.1016/S0264-410X(00)00387-X>
17. 2003) The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 33, 2987-2997.
< , F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., Bauer, S. (https://doi.org/10.1002/eji.200324238>
18. 2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
< , H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., Akira, S. (https://doi.org/10.1038/35047123>
19. 2001) Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J. Immunol. 166, 2444-2450.
< , C. J., Kiertscher, S. M., Godowski, P. J., Bouis, D. A., Norgard, M. V., Roth, M. D., Modlin, R. L. (https://doi.org/10.4049/jimmunol.166.4.2444>
20. 2004) Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation. Cell Microbiol. 6, 187-199.
< , T., Kiura, K., Yasuda, M., Kataoka, H., Inoue, N., Hasebe, A., Takeda, K., Akira, S., Shibata, K. (https://doi.org/10.1046/j.1462-5822.2003.00356.x>
21. 2002) In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16, 429-439.
< , D., Kullberg, M. C., Hieny, S., Caspar, P., Collazo, C. M., Sher, A. (https://doi.org/10.1016/S1074-7613(02)00278-9>
22. 2001) Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31, 3388-3393.
< , D., Napolitani, G., Colonna, M., Sallusto, F., Lanzavecchia, A. (https://doi.org/10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q>
23. 2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194, 863-869.
< , N., Ho, S., Antonenko, S., Maletyt, R. W., Kastelein, R. A., Bazan, F., Liu, Y. J. (https://doi.org/10.1084/jem.194.6.863>
24. 2001) Endotoxin-induced maturation o fMyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694.
< , T., Takeuchi, O., Kawai, T., Hoshino, K., Akira, S. (https://doi.org/10.4049/jimmunol.166.9.5688>
25. 2002) Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int. Immunol. 14, 695-700.
< , T., Hoshino, K., Iwabe, T., Takeuchi, O., Yasui, T., Akira, S. (https://doi.org/10.1093/intimm/dxf039>
26. 2004) Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4, 249-258.
< D. M. (https://doi.org/10.1038/nri1329>
27. 1999) Direct immunologic activities of CpG DNA and implications for gene therapy. J. Gene Med. 1, 56-63.
< , A. M. (https://doi.org/10.1002/(SICI)1521-2254(199901/02)1:1<56::AID-JGM5>3.0.CO;2-6>
28. 2000) The role of CpG motifs in innate immunity. Curr. Opin. Immunol. 12, 35-43.
< , A. M. (https://doi.org/10.1016/S0952-7915(99)00048-5>
29. 2005) Regulatory T cells: Development, function and role in autoimmunity. Autoimmunity Rev. 4, 351-363.
< , R. Y., Ansari A. A., Lian, Z. X., Gerschwin, M. E. (https://doi.org/10.1016/j.autrev.2005.01.007>
30. 2001) Type I interferons potently enhance humoral immunity and can promote iso-type switching by stimulating dendritic cells in vivo. Immunity 14, 461-470.
< , A., Schiavoni, G., D'Agostino, G., Gresser, I., Belardelli, F., Tough, D. F. (https://doi.org/10.1016/S1074-7613(01)00126-1>
31. 2004) CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 34, 1483-1487.
< , L., Gerth, A. J., Peng, S. L. (https://doi.org/10.1002/eji.200324736>
32. 2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458.
< , F. Y., Xu, D., Brint, E. K., O'Neil, L. A. J. (https://doi.org/10.1038/nri1630>
33. 2003) The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2. J. Immunol. 170, 2409-2416.
< , M., Sly, L. M., Luu, Y., Young, D., Cooper, H., Reiner, N. E. (https://doi.org/10.4049/jimmunol.170.5.2409>
34. 1998) Type I IFNs enhance the terminal differentiation of dendritic cells. J. Immunol. 161, 1947-1953.
< , T., Pang, K. C., Thomas, E., Hertzog, P., Hart, D. N., Trapani, J., Cebon, J. (https://doi.org/10.4049/jimmunol.161.4.1947>
35. 2002) Cutting edge: Immune stimulation by Neisserial porins is Toll-like receptor 2 and MyD88 dependent. J. Immunol. 168, 1533-1537.
< , P., Henneke, P., Ho, Y., Latz, E., Golenbock, D. T., Wetzler, L. M. (https://doi.org/10.4049/jimmunol.168.4.1533>
36. 2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447-454.
< , F., Tschopp, J. (https://doi.org/10.1016/j.it.2005.06.004>
37. 2001) Interferon gamma-producing ability in blood lymphocytes of patients with lung cancer through activation of the innate immune system by BCG cell wall skeleton. Int. Immunopharmacol. 1, 1559-1569.
< , M., Seya, T., Kikkawa, S., Tsuji, S., Shida, K., Nomura, M., Kurita-Taniguchi, M., Ohigashi, H., Yokouchi, H., Takami, K., Hayashi, A., Azuma, I., Masaoka, T., Kodama, K., Toyoshima, K., Higashiyama, M. (https://doi.org/10.1016/S1567-5769(01)00071-6>
38. 2003) Induction of apoptosis by Toll-like receptor-7 agonist in tissue cultures. Br. J. Dermatol. 66, 9-14.
< , T., Nindl, I., Schmook, T., Ulrich, C., Sterry, W., Stocktleth, E. (https://doi.org/10.1046/j.0366-077X.2003.05632.x>
39. 2001) The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J. Biol. Chem. 276, 25680-25686.
< , K. S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C. J., Schumann, R. R. (https://doi.org/10.1074/jbc.M011615200>
40. 1999) Treatment of primary herpes simplex virus infection in guinea pigs by imiquimod. Antiviral Res. 44, 31-42.
< , R. L., Imbertson, L. M., Reiter, M. J., Gerster, J. F. (https://doi.org/10.1016/S0166-3542(99)00052-2>
41. 2002) Immunomodulation as a treatment strategy for genital herpes: review of the evidence. Int. Immunopharmacol. 2, 443-451.
< , R. L., Tomai, M. A., Harrison, C. J., Bernstein, D. I. (https://doi.org/10.1016/S1567-5769(01)00184-9>
42. 2000) Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164, 5998-6004.
< , M., Bosisio, D., Polentarutti, N., D'amico, G., Stoppacciaro, A., Mancinelli, R., van't Veer, C., Penton-Rol, G., Ruco, L. P., Allavena, P., Mantovani, A. (https://doi.org/10.4049/jimmunol.164.11.5998>
43. 2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036.
< , C., Medzhitov, R. (https://doi.org/10.1126/science.1078231>
44. 2004) Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21, 733-741.
< , C., Medzhitov, R. (https://doi.org/10.1016/j.immuni.2004.10.006>
45. 1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283, 1183-1186.
< , M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., de Waal Maletyt, R., Liu, Y. J. (https://doi.org/10.1126/science.283.5405.1183>
46. 1998) Oral bropirimine immunotherapy of bladder carcinoma in situ after prior intravesical bacille Calmette-Guerin. Urology 51, 226-231.
< , M. F., Manyak, M. J., Sagalowsky, A. I., Belldegrun, A., Benson, M. C., Bihrle, W., Carroll, P. R., Ellis, W. J., Hudson, M. A., Sharkey, F. E. (https://doi.org/10.1016/S0090-4295(97)00510-4>
47. 2004) Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod. Apoptosis 9, 291-298.
< , M. P., Schon, M. (https://doi.org/10.1023/B:APPT.0000025805.55340.c3>
48. 1998) Paclitaxel, bropirimine and linomide: effect on growth inhibition in a murine prostate cancer model by different growth regulatory mechanisms. Methods Find. Exp. Clin. Pharmacol. 20, 111-114.
< , M., Ratanawong, S., Chou, P., Ray, V., Mirochnik, Y., Slobodskoy, L., Rubenstein, M., Guinan, P. (https://doi.org/10.1358/mf.1998.20.2.481838>
49. 1999) The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835-1837.
< , F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., Liu, Y. J. (https://doi.org/10.1126/science.284.5421.1835>
50. 2002) In vitro antitumor activity of bropirimine against urinary bladder tumor cells. Anticancer Res. 22, 1667-1671.
, Y., Matsuyama, H., Wada, T., Kurisu, H., Tahara, M., Naito, K. (
51. 2002) TLR4, but not TLR2, mediates IFN-beta-induced STAT1 alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 3, 392-398.
< , V., Jones, B. W., Perera, P. Y., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R., Major, J., Hamilton, T. A., Fenton, M. J., Vogel, S. N. (https://doi.org/10.1038/ni774>
52. 1997) Loxoribine affects fludarabine activity on freshly isolated B-chronic lymphocytic leukemia cells. Leuk. Lymphoma 26, 343-348.
< , P., Zinzani, P. L., Pellacani, A., Ottaviani, E., Magagnoli, M., Tura, S. (https://doi.org/10.3109/10428199709051784>
53. 2000) Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect. Immun. 68, 6883-6890.
< , S., Matsumoto, M., Takeuchi, O., Akira, S., Azuma, I., Hayashi, A., Toyoshima, K., Seya, T. (https://doi.org/10.1128/IAI.68.12.6883-6890.2000>
54. 2001) Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166, 249-255.
< , A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S. K., Segal, D. M. (https://doi.org/10.4049/jimmunol.166.1.249>
55. 1999) Results of a European comparative randomized study comparing oral bropirimine versus intravesical BCG treatment in BCG-naive patients with carcinoma in situ of the urinary bladder. European Bropirimine Study Group. Eur. Urol. 36, 576-581.
< , W. P., Konig, M., Boeminghaus, F. P., Hall, R. R., Schulman, C. C., Zurlo, M., Fittipaldo, A., Riggi, M., Debruyne, F. M. (https://doi.org/10.1159/000020051>
56. 1992) Shigella flexneri induces apoptosis in infected macrophages. Nature 358, 167-169.
< , A., Prevost, M. C., Sansonetti, P. J. (https://doi.org/10.1038/358167a0>