The K469E Polymorphism of the Intracellular Adhesion Molecule 1 (<i>ICAM-1</i>) Gene Is Not Associated with Myocardial Infarction in Caucasians with Type 2 Diabetes

Milutinović, A.; Petrovič, Daniel

doi:10.14712/fb2006052030079

Fol. Biol. 2006, 52, 79-80

https://doi.org/10.14712/fb2006052030079

The K469E Polymorphism of the Intracellular Adhesion Molecule 1 (ICAM-1) Gene Is Not Associated with Myocardial Infarction in Caucasians with Type 2 Diabetes

A. Milutinović, Daniel Petrovič

Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia

Received June 2006
Accepted June 2006

Type 2 diabetes is one of the major risk factors for the development of CAD and subsequent MI. Inflammation, whereby ICAM-1 plays an important role, has been implicated in the pathogenesis of MI. The K469E polymorphism of the ICAM-1 gene has recently been associated with ischemic stroke, atherosclerosis of femoral arteries and microvascular complications of type 2 diabetes. We examined the association between the K469E polymorphism of the ICAM-1 gene and MI among the patients with type 2 diabetes in Slovenian population. Genotyping of the K469E polymorphism of the ICAM-1 gene was performed for 367 subjects with type 2 diabetes: 152 patients with MI and 215 with no history of CAD. The K469E ICAM-1 genotype distribution in patients with MI (EE = 21.7 %, EK = 47.4 %, KK = 30.9 %) did not differ from genotype distribution in patients without CAD (EE = 19.1 %, EK = 50.7 %, KK = 30.2 %), and the EE genotype was not associated with MI in subjects with type 2 diabetes (P = 0.5). In conclusion, the K469E polymorphism of the ICAM-1 gene was not associated with MI in patients with type 2 diabetes, and therefore may not be used as a genetic marker for MI in patients with type 2 diabetes.