Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

Crossref logo

Fol. Biol. 2007, 53, 79-84

https://doi.org/10.14712/fb2007053030079

Experimental Therapy with 9-[2-(Phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): Origin of Resistance

Michal Zápotocký1,2, J. Hanzalová2, J. Starková1, I. Votruba3, A. Holý3, Berta Otová2

1Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
2Institute of Biology and Medical Genetics, 1st Faculty of Medicine and General Teaching Hospital, Charles University, Prague, Czech Republic
3Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Received February 2007
Accepted April 2007

References

1. Birkuš, G., Votruba, I., Holý, A., Otová, B. (1999) PMEApp as a substrate toward replicative DNA polymerases δ, and ε*. Biochem. Pharamacol. 58, 487-492. <https://doi.org/10.1016/S0006-2952(99)00118-5>
2. Bobková, K., Otová, B., Marinov, I., Mandys, V., Panczak, A., Votruba, I. Holý, A. (2000) Anticancer effect of PMEDAP - monitoring of apoptosis. Anticancer Res. 20, 1041-1048.
3. Bobková, K., Gut, I., Mandys, V., Holý, A., Votruba, I., Otová, B. (2001) Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/Cub rat strain bearing T-cell lymphoma. Anticancer Res. 21, 2725-2732.
4. Franěk, F., Holý, A., Votruba, I., Eckschlager, T. (1998) Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue. Cytotechnology 28, 65-72. <https://doi.org/10.1023/A:1008017328061>
5. Gauthier, E. R., Madison, S. D., Michel, R. N. (1997) Rapid RNA isolation without the use of commercial kits: application to small tissue samples. Pflugers Arch. 433, 664-668. <https://doi.org/10.1007/s004240050328>
6. Hatse, S., De Clercq, E., Balzarini J. (1998) Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacine-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line. Mol. Pharmacol. 54, 907-917. <https://doi.org/10.1124/mol.54.5.907>
7. Holý, A., Rosenberg, I., Dvořáková, H. (1989) Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases. Collect. Czech. Chem. Commun. 54, 2190-2210. <https://doi.org/10.1135/cccc19892190>
8. Holý, A. (2003) Phosphonomethoxyalkyl analogs of nucleotides. Curr. Pharm. Des. 9, 2567-2592. <https://doi.org/10.2174/1381612033453668>
9. Horská, K., Votruba, I., Holý, A. (2006) Interaction of phosphates of the acyclic nucleoside phosphonates with NDP kinase from yeast and bovine liver. Collect. Czech. Chem. Commun. 71, 35-43. <https://doi.org/10.1135/cccc20060035>
10. Kramata, P., Votruba, I., Otová, B., Holý, A. (1996) Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases δ and ε. Mol. Pharmacol. 49, 1005-1011.
11. Kramata, P., Downey, K. M., Paborsky, L. R. (1998) In corporation and excision of 9-(2-phosphonylmethoxyethyl)guanine by DNA polymerace δ and ε in vitro. J. Biol. Chem. 273, 21966-21971. <https://doi.org/10.1074/jbc.273.34.21966>
12. Krejčová, R., Horská, K., Votruba, I., Holý, A. (2000) Phosphorylation of purine phosphonomethoxyalkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Collect. Czech. Chem. Commun. 65, 1653-1668. <https://doi.org/10.1135/cccc20001653>
13. Lee, K., Klein-Szanto, A. J. P., Kruh, G. D. (2000) Analysis of the MRP4 drug resistant profile in transfected NIH3T3. J. Natl. Cancer Inst. 92, 1934-1940. <https://doi.org/10.1093/jnci/92.23.1934>
14. Morrison, T. M., Weiss, J. J., Wittwer, C. T. (1998) Quantification of low-copy transcripts by continuous SYBR green I monitoring during amplification. Biotechniques 24, 954-962.
15. Otová, B., Zídek, Z., Holý, A., Votruba, I., Sladká, M., Marinov, I., Lešková, V. (1997) Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP. In vivo 11, 163-168.
16. Otová, B., Francová, K., Franěk, F., Koutnik, P., Votruba, I., Holý, A., Sladká, M., Schramlová, J. (1999) 9-[2-(Phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) - a potential drug against hematological malignancies - induces apoptosis. Anticancer Res. 19, 3173-3182.
17. Otová, B., Sladká, M., Damoiseaux, J., Panczak, A., Mandys, V., Marinov, I. (2002) Relevant animal model of human lymphoblastic leukaemia/lymphoma – spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub). Folia Biol. (Praha) 48, 213-226.
18. Sampath, J., Adachi, M., Hatse, S., Naesens, L., Balzarini, J., Flatley, R., Matherly, L., Schuetz, J. (2002) Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 4, 1-9. <https://doi.org/10.1208/ps040314>
19. Schuetz, J., Connelly M., Sun, D., Paibir, S., Flynn, P. M., Srinivaa, R. V., Kumar, A., Fridland, A. (1999) MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drug. Nat. Med. 5, 1048-1051. <https://doi.org/10.1038/12487>
20. Veselý, J., Merta, A., Votruba, I., Holý, A., Rosenberg, I. (1990) The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L-1210 mouse leukemic cells. Neoplasma 37, 105-110.
21. Wijnholds, J., Mol, C. A., van Deemter, L., de Haas, M., Scheffer, G. L., Baas, F., Beijnen, J. H., Scheper, R., Hatse, S., De Clercq, E., Balzarini, J., Borst, P. (2000) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc. Natl. Acad. Sci. USA 97, 7476-7481. <https://doi.org/10.1073/pnas.120159197>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive