Fol. Biol. 2008, 54, 40-45

https://doi.org/10.14712/fb2008054020040

The Influence of Two megsin Polymorphisms on the Progression of IgA Nephropathy

Dita Maixnerová1, M. Merta1, J. Reiterová1, J. Štekrová2, R. Ryšavá1, O. Viklický3, H. Obeidová1, V. Tesař1

1Charles University in Prague, First Faculty of Medicine, Department of Nephrology, Czech Republic
2Charles University in Prague, First Faculty of Medicine, Department of Biology and Human Genetics, Czech Republic
3Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Received October 2007
Accepted April 2008

References

1. Bachmann, F. (1995) The enigma PAI-2: Gene expression, evolutionary and functional aspects. Thromb. Haemostasis 74, 172-179.
2. Bartosik, L. P., Lajoie, G., Sugar, L. (2001) Predicting progression in IgA nephropathy. Am. J. Kidney Dis. 38, 728-735. <https://doi.org/10.1053/ajkd.2001.27689>
3. Bird, P. I. (1998) Serpins and regulation of cell death. Results Probl. Cell Differ. 24, 63-89. <https://doi.org/10.1007/978-3-540-69185-3_4>
4. D’Amico, G. (2004) Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin. Nephrol. 24, 179-196. <https://doi.org/10.1016/j.semnephrol.2004.01.001>
5. Daniel, L., Sainna, Y., Giorgi, R. (2000) Tubular lesions determine prognosis of IgA nephropathy. Am. J. Kidney Dis. 35, 13-20. <https://doi.org/10.1016/S0272-6386(00)70295-2>
6. Davie, M., Martin, J., Thomas, G. J., Lovett, D. H. (1992) Proteinases and glomerular matrix turnover. Kidney Int. 41, 671-678. <https://doi.org/10.1038/ki.1992.103>
7. Donadio, J. V., Bergstralh, E. J., Grande, J. P. (2002) Proteinuria patterns and their association with subsequent end-stage renal disease in IgA nephropathy. Nephrol. Dial. Transplant. 17, 1197-1203. <https://doi.org/10.1093/ndt/17.7.1197>
8. Eitzman, D. T., McCoy, R. D., Zheng, X., Fay, W. P., Shen, T., Ginsburg, D. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J. Clin. Invest. 97, 232-237. <https://doi.org/10.1172/JCI118396>
9. Goto, S., Narita, I., Saito, N., Watanabe, Y., Yamazaki, H., Sakatsume, M., Shimada, H., Nishi, S., Ueno, M., Akazawa, K., Arakawa, M., Gejyo, F. (2002) A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy. Kidney Int. 62, 980-985. <https://doi.org/10.1046/j.1523-1755.2002.00517.x>
10. Hsu, S. I., Ramirez, S. B., Winn, M. P., Bonventre, J. V., Owen, W. F. (2000) Evidence for genetic factors in the development and progression of IgA nephropathy. Kidney Int. 57, 1818-1835. <https://doi.org/10.1046/j.1523-1755.2000.00032.x>
11. Inagi, R., Miyata, T., Suzuki, D., Toyoda, M., Wada, T., Kurokawa, K. (2001) Specific tissue distribution of Megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy. Biochem. Biophys. Res. Commun. 286, 1098-1106. <https://doi.org/10.1006/bbrc.2001.5509>
12. Inagi, R., Miyata, T., Imasawa, T., Nangaku, M., Kurokawa, K. (2002a) Mesangial cell-predominant functional gene, megsin. Nephrol. Dial. Transplant. 17, (9) 32-33. <https://doi.org/10.1093/ndt/17.suppl_9.32>
13. Inagi, R., Miyata, T., Nangaku, M., Ueyama, H., Takeyama, K., Kato, S., Kurokawa, K. (2002b) Transcriptional regulation of a mesangium-predominant gene, megsin. J. Am. Soc. Nephrol. 13, 2715-2722. <https://doi.org/10.1097/01.ASN.0000033507.32175.FA>
14. Inagi, R., Miyata, T., Kurokawa, K. (2003) Mesangial cell-predominant functional gene, megsin. Clin. Exp. Nephrol. 7, 87-92. <https://doi.org/10.1007/s10157-003-0228-0>
15. Johnson, R. J., Lovett, D., Lehrer, R. I., Couser, W. G., Klebanoff, S. J. (1994) Role of oxidants and proteases in glomerular injury. Kidney Int. 45, 352-359. <https://doi.org/10.1038/ki.1994.45>
16. Kim, Y. S., Kang, D., Kwon, D. Y. (2001) Uteroglobin gene polymorphisms affect the progression of immunoglobulin A nephropathy by modulating the level of uteroglobin expression. Pharmacogenetics 11, 299-305. <https://doi.org/10.1097/00008571-200106000-00004>
17. Kobayashi, Y., Kokubo, T., Horii, A. (1997) Prognostic prediction of long-term clinical courses in individual IgA nephropathy patients. Nephrology 3, 35-40. <https://doi.org/10.1111/j.1440-1797.1997.tb00186.x>
18. Kruithof, E. K. O., Baker, M. S., Bunn, C. L. (1995) Biological and clinical aspects of plasminogen activator inhibitor type 2. Blood 86, 4007-4024. <https://doi.org/10.1182/blood.V86.11.4007.bloodjournal86114007>
19. Lau, Y. K., Woo, K. T., Choong, H. L., Zhao, Y., Tan, H. B., Chong, S. M., Tan, E. K., Yap, H. K., Wong, K. S. (2004) Renin-angiotensin system gene polymorphisms: its impact on IgAN and its progression to end-stage renal failure among Chinese in Singapore. Nephron Physiol. 97, 1-8. <https://doi.org/10.1159/000077596>
20. Li, Y., DU, Y., Li, C., Guo, H., Leung, J. C. K., Lam, M. F., Yang, N., Huang, F., Chen, Y., Fang, J., Maxwell, P. H., Lai, K. N., Wang, Y. (2004) Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3’ untranslated region of the Megsin gene. J. Am. Soc. Nephrol. 15, 1739-1743. <https://doi.org/10.1097/01.ASN.0000130858.00688.46>
21. Miyata, T., Nangaku, M., Suzuki, D. (1998) A mesangium predominant gene, megsin, is a new serpin upregulated in IgA nephropathy. J. Clin. Invest. 102, 828-836. <https://doi.org/10.1172/JCI2450>
22. Narita, I., Saito, N., Goto, S. (2002) Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. Kidney Int. 61, 1853-1858. <https://doi.org/10.1046/j.1523-1755.2002.00336.x>
23. Narita, I., Goto, S., Saito, N., Song, J., Omori, K., Kondo, D., Sakatsume, M., Gejyo, F. (2003a) Angiotensinogen gene variation and renoprotective efficacy of renin-angiotensin system blockade in IgA nephropathy. Kidney Int. 64, 1050-1058. <https://doi.org/10.1046/j.1523-1755.2003.00187.x>
24. Narita, I., Goto, S., Saito, N., Song, J., Ajiro, J., Sato, F., Saga, D., Kondo, D., Akazawa, K., Sakatsume, M., Gejyo, F. (2003b) Interaction between ACE and ADD1 gene polymorphisms in the progression of IgA nephropathy in Japanese patients. Hypertension 42, 304-309. <https://doi.org/10.1161/01.HYP.0000085193.25617.78>
25. O’Relly, M. S., Pirie-Shepherd, S., Lane, W. S., Folkman, J. (1999) Antiantiogenic activity of the cleaved conformation of the serpin antithrombin. Science 285, 1926-1928. <https://doi.org/10.1126/science.285.5435.1926>
26. Rauta, V., Finne, P., Fagerudd, J. (2002) Factors associated with progression of IgA nephropathy are related to renal function. A model for estimating risk of progression in mild disease. Clin. Nephrol. 58, 85-94. <https://doi.org/10.5414/CNP58085>
27. Song, J., Sakatsume, M., Narita, I., Goto, S., Omori, K., Takada, T., Saito, N., Ueno, M., Gejyo, F. (2003) Peroxisome proliferator-activated receptor γ C161T polymorphisms and survival of Japanese patients with immunoglobulin A nephropathy. Clin. Genet. 64, 398-403. <https://doi.org/10.1034/j.1399-0004.2003.00154.x>
28. Suzuki, D., Miyata, T., Nangaku, M., Takano, H., Saotome, N., Sakai, H. (1999) Expression of Megsin mRNA, a novel mesangium-predominant gene, in the renal tissues of various glomerular diseases. J. Am. Soc. Nephrol. 10, 2606-2613. <https://doi.org/10.1681/ASN.V10122606>
29. Syrjanen, J., Huang, X. H., Mustonen, J., Koivula, T., Lehtimaki, T., Pasternack, A. (2000a) Angiotensin-converting enzyme insertion/deletion polymorphism and prognosis of IgA nephropathy. Nephron 86, 115-121. <https://doi.org/10.1159/000045728>
30. Syrjanen, J., Mustonen, J., Pasternack, A. (2000b) Hypertriglyceridemia and hyperuricemia are risk factors for progression of IgA nephropathy. Nephrol. Dial. Transplant. 15, 34-42. <https://doi.org/10.1093/ndt/15.1.34>
31. Szelestei, T., Bahring, S., Kovací, T., Vas, T., Salomon, C., Busjahn, A., Luft, F. C., Nagy, J. (2000) Association of a uteroglobin polymorphism with rate of progression in patiens with IgA nephropathy. Am. J. Kidney Dis. 36, 468-473. <https://doi.org/10.1053/ajkd.2000.9786>
32. Xia, Y., Li, Y., Du, Y., Yang, N., Li, C., Leung, J. C. K., Lam, M. F., Huang, W., Chen, S., Maxwell, P. H., Lai, K. N., Wang, Y. (2006) Association of Megsin 2093C-2180T haplotype at the 3´untranslated region with disease severity and progression of IgA nephropathy. Nephrol. Dial. Transplant. 21, 1570-1574. <https://doi.org/10.1093/ndt/gfk096>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive