Influence of COX-2-Induced PGE<sub>2</sub> on the Initiation and Progression of Tail Regeneration in Northern House Gecko, <i>Hemidactylus flaviviridis</i>

Sharma, Priyamka; Suresh, B.

doi:10.14712/fb2008054060193

Folia Biologica > Archive > 2008, Vol. 54 > Issue 6 > Influence of COX-2-Induced…

Fol. Biol. 2008, 54, 193-201

https://doi.org/10.14712/fb2008054060193

Influence of COX-2-Induced PGE₂ on the Initiation and Progression of Tail Regeneration in Northern House Gecko, Hemidactylus flaviviridis

Priyamka Sharma, B. Suresh

Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India

Received September 2008
Accepted November 2008

We investigated the role of prostaglandin E₂ in reptilian regeneration. Prostaglandin E₂ is known to play a vital role during wound healing and cell proliferation. A significant delay in the rate of growth of regenerate after autotomy was observed when the production of prostaglandin E₂ was blocked by usage of specific cyclooxygenase inhibitors as compared to control animals and this delay continued to all the defined stages of regeneration. Therefore, prostaglandin E₂ could be one of the essential requirements for a successful process of regeneration.