Fol. Biol. 2008, 54, 177-179
Re-differentiation of Human Articular Chondrocytes Is Not Enhanced by a Rotary Bioreactor System
ACI is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. The method is based on in vitro chondrocyte cultivation. Two different culture conditions, rotating-wall-vessel bioreactor and static culture, were assessed by their effect on the re-differentiation potential of human articular chondrocytes seeded into a hydrogel scaffold. Gene expression analysis of the tissue-engineered construct revealed no significant difference between the tested systems.
Keywords
human articular chondrocytes, real-time PCR, rotary bioreactor system, hydrogel scaffold, tissue engineering.
Funding
The study was supported by the Slovenian Research Agency under the Research project L7-7598.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
