Fol. Biol. 2009, 55, 17-22

https://doi.org/10.14712/fb2009055010017

Efficient Human Growth Hormone Gene Expression in the Milk of Non-transgenic Goats

Z. Han1,2, S. Wu1,2, Qingwang Li1,2, J. Li2, D. Gao2, K. Li2, Z. W. Liu2, H. Zhao2

1College of Animal Science and Veterinary Medicine, Northwest A&F University, Yangling, China
2Department of Biological Engineering, College of Environment & Chemical Engineering, Yanshan University, Qinhuangdao, China

Received August 2008
Accepted January 2009

References

1. Archer, J. S., Kennan, W. S., Gould, M. N., Bremel, R. D. (1994) Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors. Proc. Natl. Acad. Sci. USA 91, 6840-6844. <https://doi.org/10.1073/pnas.91.15.6840>
2. Bösze, Z., Baranyi, M., Whitelaw, C. B. (2008) Producing recombinant human milk proteins in the milk of livestock species. Adv. Exp. Med. Biol. 606, 357-393. <https://doi.org/10.1007/978-0-387-74087-4_15>
3. Chu, Q., St George, J. A., Lukason, M., Cheng, S. H., Scheule, R. K., Eastman, S. J. (2001) EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo. Hum. Gene Ther. 12, 455-467. <https://doi.org/10.1089/104303401300042348>
4. Douglas, J. T. (2007) Adenoviral vectors for gene therapy. Mol. Biotechnol. 36, 71-80. <https://doi.org/10.1007/s12033-007-0021-5>
5. Fan, W., Plaut, K., Bramley, A. J., Barlow, J. W., Kerr, D. E. (2002) Adenoviral-mediated transfer of a lysostaphin gene into the goat mammary gland. J. Dairy Sci. 85, 1709-1716. <https://doi.org/10.3168/jds.S0022-0302(02)74244-6>
6. Fan, W., Plaut, K., Bramley, A. J., Barlow, J. W., Mischler, S. A., Kerr, D. E. (2004) Persistency of adenoviral-mediated lysostaphin expression in goat mammary glands. J. Dairy Sci. 87, 602-608. <https://doi.org/10.3168/jds.S0022-0302(04)73202-6>
7. Han, Z. S., Li, Q. W., Zhang, Z. Y., Xiao, B., Gao, D. W., Wu, S. Y., Li, J., Zhao, H. W., Jiang, Z. L., Hu, J. H. (2007) High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors. Protein Expr. Purif. 53, 225-231. <https://doi.org/10.1016/j.pep.2006.11.019>
8. Hawkins, R. L., Nakamura, M. (1999) Expression of human growth hormone by the eukaryotic alga, Chlorella. Curr. Microbiol. 38, 335-341. <https://doi.org/10.1007/PL00006813>
9. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., Vogelstein, B. (1998) A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95, 2509-2514. <https://doi.org/10.1073/pnas.95.5.2509>
10. Hens, J. R., Amstutz, M. D., Schanbacher, F. L., Mather, I. H. (2000) Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactation. Biochim. Biophys. Acta 1523, 161-171. <https://doi.org/10.1016/S0304-4165(00)00117-3>
11. Houdebine, L. M. (2000) Transgenic animal bioreactors. Transgenic Res. 9, 305-320. <https://doi.org/10.1023/A:1008934912555>
12. Houdebine, L. M. (2005) Use of transgenic animals to improve human and animal health. Reprod. Dom. Anim. 40, 269-281. <https://doi.org/10.1111/j.1439-0531.2005.00596.x>
13. Johnson, L. G., Vanhook, M. K., Coyne, C. B., Haykal- Coates, N., Gavett., S. H. (2003) Safety and efficiency of modulating paracellular permeability to enhance airway epithelial gene transfer in vivo. Hum. Gene Ther. 14, 729-747. <https://doi.org/10.1089/104303403765255138>
14. Kajino, T., Saito, Y., Asami, O., Yamada, Y., Hirai, M., Udata, S. (1997) Extracellular production of an intact and biologically active human growth hormone by the Bacillus brevis system. J. Ind. Microbiol. Biotechnol. 19, 227-231. <https://doi.org/10.1038/sj.jim.2900445>
15. Lipiński, D., Jura, J., Kalak, R., Pławski, A., Kala, M., Szalata, M., Jarmuz, M., Korcz, A., Słomska, K., Jura, J., Gronek, P., Smorag, Z., Pieńkowski, M., Słomski, R. (2003) Transgenic rabbit producing human growth hormone in milk. J. Appl. Genet. 44, 165-174.
16. Mikuš, T., Malý, P., Poplštein, M., Landa, V., Trefil, P., Lidický, J. (2001) Expression of human erythropoietin gene in the mammary gland of a transgenic mouse. Folia Biol. (Praha) 47, 187-195.
17. Peebles, D., Gregory, L. G., David, A., Themis, M., Waddington, S. N., Knapton, H. J., Miah, M., Cook, T., Lawrence, L., Nivsarkar, M., Rodeck, C., Coutelle, C. (2004) Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero. Gene Ther. 11, 70-78. <https://doi.org/10.1038/sj.gt.3302130>
18. Rees, S., Coote, J., Stables, J., Goodson, S., Harris, S., Lee, M. G. (1996) Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein. Biotechniques 20, 102-104, 106, 108-110. <https://doi.org/10.2144/96201st05>
19. Rosen, J. M., Li, S., Raught, B., Hadsell, D. (1996) The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes. Am. J. Clin. Nutr. 63, 627S-632S. <https://doi.org/10.1093/ajcn/63.4.627>
20. Salamone, D., Barañao, L., Santos, C., Bussmann, L., Artuso, J., Werning, C., Prync, A., Carbonetto, C., Dabsys, S., Munar, C., Salaberry, R., Berra, G., Berra, I., Fernández, N., Papouchado, M., Foti, M., Judewicz, N., Mujica, I., Muñoz, L., Alvarez, S. F., González, E., Zimmermann, J., Criscuolo, M., Melo, C. (2006) High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow. J. Biotechnol. 124, 469-472. <https://doi.org/10.1016/j.jbiotec.2006.01.005>
21. Sánchez, O., Toledo, J. R., Rodríguez, M. P., Castro, F. O. (2004) Adenoviral vector mediates high expression levels of human growth hormone in the milk of mice and goats. J. Biotechnol. 114, 89-97. <https://doi.org/10.1016/j.jbiotec.2004.06.009>
22. Oledo, J. R., Sanchez, O., Segui, R. M., García, G., Montañez, M., Zamora, P. A., Rodríguez, M. P., Cremata, J. A. (2006) High expression level of recombinant human erythropoietin in the milk of non-transgenic goats. J. Biotechnol. 123, 225-235.
23. Walsh, G., Jefferis, R. (2006) Post-translational modifications in the context of therapeutic proteins. Nat. Biotechnol. 24, 1241-1252. <https://doi.org/10.1038/nbt1252>
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