Fol. Biol. 2009, 55, 35-40

https://doi.org/10.14712/fb2009055020035

Association of Paraoxonase 55 and 192 Gene Polymorphisms on Serum Homocysteine Concentrations in Preeclampsia

E. Isbilen1, H. Yilmaz2, H. Arzu Ergen2, Y. Unlucerci3, Turgay Isbir2, F. Gurdol3

1Baskent University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey
2Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
3Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

Received February 2008
Accepted January 2009

References

1. Adkins, S., Gan, K. N., Mody, M., La Du, B. N. (1993) Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes. Am. J. Hum. Genet. 52, 598-608.
2. Agaçhan, B., Yilmaz, H., Karaali, Z., Isbir, T. (2004) Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus. Cell Biochem. Funct. 22, 163-168. <https://doi.org/10.1002/cbf.1070>
3. Agaçhan, B., Yilmaz, H., Ergen, H. A., Karaali, Z. E., Isbir, T. (2005) Paraoxonase (PON1) 55 and 192 polymorphism and its effects to oxidant-antioxidant system in Turkish patients with type 2 diabetes mellitus. Physiol. Res. 54, 287-293. <https://doi.org/10.33549/physiolres.930530>
4. Antikainen, M., Murtomäki, S., Syvänne, M., Pahlman, R., Tahvanainen, E., Jauhiainen, M., Frick, M. H., Ehnholm, C. (1996) The Gln Arg 191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns. J. Clin. Invest. 98, 883-885. <https://doi.org/10.1172/JCI118869>
5. Bilge, I., Sirin, A., Agaçhan, B., Emre, S., Sadikoglu, B., Yilmaz, H., Sucu, A., Isbir, T. (2007) Is paraoxonase 192 gene polymorphism a risk factor for membranoproliferative glomerulonephritis in children? Cell Biochem. Funct. 25, 159-165. <https://doi.org/10.1002/cbf.1288>
6. Braekke, K., Ueland, P. M., Harsem, N. K., Karlsen, A., Blomhoff, R., Staff, A. C. (2007) Homocysteine, cysteine, and related metabolites in maternal and fetal plasma in preeclampsia. Pediatr. Res. 62, 319-324. <https://doi.org/10.1203/PDR.0b013e318123fba2>
7. Dekker, G. A., van Geijn, H. P. (1996) Endothelial dysfunction in preeclampsia. Part II. Reducing the adverse consequences of endothelial cell dysfunction in preeclampsia; therapeutic perspectives. J. Perinat. Med. 24, 119-139. <https://doi.org/10.1515/jpme.1996.24.2.119>
8. Eckerson, H. W., Wyte, C. M., La Du, B. N. (1983) The human serum paraoxonase/arylesterase polymorphism. Identification of phenotypes by their response to salts. Am. J. Hum. Genet. 35, 214-227.
9. Gardemann, A., Philipp, M., Hess, K., Katz, N., Tillmanns, H., Haberbosch, W. (2000) The paraoxonase Leu Met54 and Gln Arg191 gene polymorphisms are not associated with the risk of coronary heart disease. Atherosclerosis 152, 421-431. <https://doi.org/10.1016/S0021-9150(99)00489-X>
10. Gratacos, E., Casals, E., Deulofeu, R., Cararach, V., Alonso, P. L., Fortuny, A. (1998) Lipid peroxide and vitamin E patterns in pregnant women with different types of hypertension in pregnancy. Am. J. Obstet. Gynecol. 178, 1072-1076. <https://doi.org/10.1016/S0002-9378(98)70550-2>
11. Gratacos, E. (2000) Lipidmediated endothelial dysfunction: a common factor to preeclampsia and chronic vascular disease. Eur. J. Obstet. Gynecol. Reprod. Biol. 92, 63-66. <https://doi.org/10.1016/S0301-2115(00)00427-9>
12. Herrmann, S. M., Blanc, H., Poirier, O., Arveiler, D., Luc, G., Evans, A., Marques-Vidal, P., Bard, J. M., Cambien, F. (1996) The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM study. Atherosclerosis 126, 299-304. <https://doi.org/10.1016/0021-9150(96)05917-5>
13. Holmes, V. A., Wallace, J. M., Alexander, H. D., Gilmore, W. S., Bradbury, I., Ward, M., Scott, J. M., Mcfaul, P., McNulty, H. (2005) Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation. Clin. Chem. 51, 629-634. <https://doi.org/10.1373/clinchem.2004.032698>
14. Hubel, C. A. (1999) Oxidative stress in the pathogenesis of preeclampsia. Proc. Soc. Exp. Biol. Med. 222, 222-235. <https://doi.org/10.1046/j.1525-1373.1999.d01-139.x>
15. Humbert, R., Adler, D. A., Disteche, C. M., Hassett, C., Omiecinski, C. J., Furlong, C. E. (1993) The molecular basis of the human serum paraoxonase activity polymorphism. Nat. Genet. 3, 73-76. <https://doi.org/10.1038/ng0193-73>
16. Jakubowski, H., Ambrosius, W. T., Pratt, H. (2001) Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett. 491, 35-39. <https://doi.org/10.1016/S0014-5793(01)02143-3>
17. Jakubowski, H. (2002) Homocysteine is a protein amino acid in humans: Implications for homocysteinelinked disease. J. Biol. Chem. 277, 30425-30428. <https://doi.org/10.1074/jbc.C200267200>
18. Kim, Y. J., Park, H. S., Park, M. H., Suh, S. H., Pang, M., G. (2005) Oxidative stress -related gene polymorphism and the risk of preeclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 119, 42-46. <https://doi.org/10.1016/j.ejogrb.2004.06.009>
19. Kumru, S., Aydin, S., Gursu, M. F., Ozcan, Z. (2004) Changes of serum paraoxonase (an HDL cholesterolassociated lipo philic antioxidant) and arylesterase activities in severe preeclamptic women. Eur. J. Obstet. Gynecol. Reprod. Biol. 114, 177-181. <https://doi.org/10.1016/j.ejogrb.2003.10.023>
20. Lacinski, M., Skorupski, W., Cieslinski, A., Sokolowska, J., Trzeciak, W. H., Jakubowski, H. (2004) Determinants of homocysteine -thiolactonase activity of the paraoxonase1 (PON1) protein in humans. Cell Mol. Biol. 50, 885-893.
21. Lawlor, D. A., Gaunt, T. R., Hinks, L. J., Smith, G. D., Timpson, N., Day, I. A., M., Ebrahim, S. (2006) The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women’s Heart and Health cohort study. Paediatr. Perinat. Epidemiol. 20, 244-250. <https://doi.org/10.1111/j.1365-3016.2006.00716.x>
22. Mackness, B., Durrington, P. N., Mackness, M. I. (1998) Human serum paraoxonase. Gen. Pharmac. 31, 329-336. <https://doi.org/10.1016/S0306-3623(98)00028-7>
23. Mignini, L. E., Latthe, P. M., Villar, J., Kilby, M. D., Carroli, G., Khan, K. S. (2005) Mapping the theories of preeclampsia: the role of homocysteine. Obstet. Gynecol. 105, 411-425. <https://doi.org/10.1097/01.AOG.0000151117.52952.b6>
24. Miller, S. A., Dykes, D. D., Polesky, H. S. (1998) A simple salting out procedure for extracting DNA from human nucleated cells. Nucl. Acids Res. 16, 1215. <https://doi.org/10.1093/nar/16.3.1215>
25. Noris, M., Perico, N., Remuzzi, G. (2005) Mechanisms of disease: pre eclampsia. Nat. Clin. Pract. Nephrol. 1, 98-114. <https://doi.org/10.1038/ncpneph0035>
26. Roberts, J. M., Gammill, H. S. (2005) Preeclampsia: recent insights. Hypertension 46, 1243-1249. <https://doi.org/10.1161/01.HYP.0000188408.49896.c5>
27. Sarandol, E., Safak, O., Dirican, M., Uncu, G. (2004) Oxidizability of apolipoprotein B containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Clin. Biochem. 37, 990-996. <https://doi.org/10.1016/j.clinbiochem.2004.06.013>
28. Schmidt, H., Schmidt, R., Niederkorn, K., Gradert, A., Schumacher, M., Watzinger, N., Hartung, H. P., Kostner, G. M. (1998) Paraoxonase PON1 polymorphism Leu Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Stroke 29, 2043-2048. <https://doi.org/10.1161/01.STR.29.10.2043>
29. Serrato, M., Marian, A. L. (1995) A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary heart disease. J. Clin. Invest. 96, 3005-3008. <https://doi.org/10.1172/JCI118373>
30. Ubbink, J. B., Vermaak, W. H. J., Bissbort, S. (1991) Rapid high performance liquid chromatographic assay for total homocysteine levels in human serum. J. Chromatogr. 565, 441-446. <https://doi.org/10.1016/0378-4347(91)80407-4>
31. Uzun, H., Benian, A., Madazli, R., Topcuoglu, M. A., Aydin, S., Albayrak, M. (2005) Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia. Gynecol. Obstet. Invest. 60, 195-200. <https://doi.org/10.1159/000087205>
32. Yilmaz, H., Unlucerci, Y., Gurdol, F., Isbilen, E., Isbir, T. (2004) Association of pre-eclampsia with hyperhomocysteinaemia and methylene-tetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust. N. Z. J. Obstet. Gynaecol. 44, 423-427. <https://doi.org/10.1111/j.1479-828X.2004.00283.x>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive