Fol. Biol. 2009, 55, 119-125

https://doi.org/10.14712/fb2009055040119

Dendritic Cell-Based Immunotherapy Induces Transient Clinical Response in Advanced Rat Fibrosarcoma – Comparison with Preventive Anti-tumour Vaccination

A. Kučera1, K. Pýcha1, P. Pajer2, Radek Špíšek3, R. Škába1

1Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Department of Paediatric Surgery, Prague, Czech Republic
2Department of Molecular Virology, Institute of Molecular Genetics AS CR, Prague, Czech Republic
3Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Department of Immunology, Prague, Czech Republic

Received March 2009
Accepted April 2009

References

1. Antonia, S. J., Mirza, N., Fricke, I., Chiappori, A., Thompson, P., Williams, N., Bepler, G., Simon, G., Janssen, W., Lee, J. H., Menander, K., Chada, S., Gabrilovich, D. I. (2006) Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin. Cancer Res. 12, 878-887. <https://doi.org/10.1158/1078-0432.CCR-05-2013>
2. Aspord, C., Pedroza-Gonzalez, A., Gallegos, M., Tindle, S., Burton, E. C., Su, D., Marches, F., Banchereau, J., Palucka, A. K. (2007) Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J. Exp. Med. 204, 1037-1047. <https://doi.org/10.1084/jem.20061120>
3. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252. <https://doi.org/10.1038/32588>
4. Berard, F., Blanco, P., Davoust, J., Neidhart-Berard, E.-M., Nouri-Shirazi, M., Taquet, N., Rimoldi, D., Cerottini, J. C., Banchereau, J., Palucka, K. A. (2000) Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J. Exp. Med. 192, 1535-1544. <https://doi.org/10.1084/jem.192.11.1535>
5. Blattman, J. N., Greenberg, P. D. (2004) Cancer immunotherapy: a treatment for the masses. Science 305, 200-205. <https://doi.org/10.1126/science.1100369>
6. Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., Schreiber, R. D. (2002) Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3, 991-998. <https://doi.org/10.1038/ni1102-991>
7. Dunn, G. P., Old, L. J., Schreiber, R. D. (2004a) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21, 137-148. <https://doi.org/10.1016/j.immuni.2004.07.017>
8. Dunn, G. P., Old, L. J., Schreiber, R. D. (2004b) The three Es of cancer immunoediting. Annu. Rev. Immunol. 22, 329-360. <https://doi.org/10.1146/annurev.immunol.22.012703.104803>
9. Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, E., Kroemer, G., Martin, F., Chauffert, B., Zitvogel, L. (2005) Tumor cells convert immature myeloid dendritic cells into TGF-β-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J. Exp. Med. 202, 919-929. <https://doi.org/10.1084/jem.20050463>
10. Gilboa, E. (2004) The promise of cancer vaccines. Nat. Rev. Cancer 4, 401-411. <https://doi.org/10.1038/nrc1359>
11. Koebel, C. M., Vermi, W., Swann, J. B., Zerafa, N., Rodig, S. J., Old, L. J., Smyth, M. J., Schreiber, R. D. (2007) Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903-907. <https://doi.org/10.1038/nature06309>
12. Marincola, F. M., Jaffee, E. M., Hicklin, D. J., Ferrone, S. (2000) Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74, 181-273. <https://doi.org/10.1016/S0065-2776(08)60911-6>
13. Masse, D., Ebstein, F., Bougras, G., Harb, J., Meflah, K., Gregoire, M. (2004) Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy. Int. J. Cancer 111, 575-583. <https://doi.org/10.1002/ijc.20249>
14. Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., Métivier, D., Larochette, N., van Endert, P., Ciccosanti, F., Piacentini, M., Zitvogel, L., Kroemer, G. (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13, 54-61. <https://doi.org/10.1038/nm1523>
15. Rosenberg, S. A., Yang, J. C., Restifo, N. P. (2004) Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909-915. <https://doi.org/10.1038/nm1100>
16. Spisek, R., Chevallier, P., Morineau, N., Milpied, N., Avet-Loiseau, H., Harousseau, J. L., Meflah, K., Gregoire, M. (2002) Induction of leukemia-specific cytotoxic response by cross presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin. Cancer Res. 62, 2861-2868.
17. Spisek, R., Brazova, J., Rozkova, D., Zapletalova, K., Sediva, A., Bartunkova, J. (2004) Maturation of dendritic cells by bacterial immunomodulators. Vaccine 22, 2761-2768. <https://doi.org/10.1016/j.vaccine.2004.01.006>
18. Spisek, R. (2006) Immunoprevention of cancer: time to reconsider timing of vaccination against cancer. Expert Rev. Anticancer Ther. 6, 1689-1691. <https://doi.org/10.1586/14737140.6.12.1689>
19. Spisek, R., Dhodapkar, M. V. (2006) Immunoprevention of cancer. Hematol. Oncol. Clin. North Am. 20, 735-750. <https://doi.org/10.1016/j.hoc.2006.02.009>
20. Spisek, R., Dhodapkar, M. V. (2007) Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells. Cell Cycle 6, 1962-1965. <https://doi.org/10.4161/cc.6.16.4601>
21. Spisek, R., Charalambous, A., Mazumder, A., Vesole, D. H., Jagannath, S., Dhodapkar, M. V. (2007) Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 109, 4839-4845. <https://doi.org/10.1182/blood-2006-10-054221>
22. Steinman, R. M., Banchereau, J. (2007) Taking dendritic cells into medicine. Nature 449, 419-426. <https://doi.org/10.1038/nature06175>
23. Tobiasova, Z., Pospisilova, D., Miller, A. M., Minarik, I., Sochorova, K., Spisek, R., Rob, L., Bartunkova, J. (2007) In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients. Clin. Immunol. 122, 18-27. <https://doi.org/10.1016/j.clim.2006.09.003>
24. Wheeler, C. J., Das, A., Liu, G., Yu, J. S., Black, K. L. (2004) Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination. Clin. Cancer Res. 10, 5316-5326. <https://doi.org/10.1158/1078-0432.CCR-04-0497>
25. Yu, J. S., Wheeler, C. J., Zeltzer, P. M., Ying, H., Finger, D. N., Lee, P. K, Yong, W. H., Incardona, F., Thompson, R. C., Riedinger, M. S., Zhang, W., Prins, R. M, Black, K. L. (2001) Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res. 61, 842-847.
26. Zitvogel, L., Apetoh, L., Ghiringhelli, F., Kroemer, G. (2008) Immunological aspects of cancer chemotherapy. Nat. Rev. Immunol. 8, 59-73. <https://doi.org/10.1038/nri2216>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive