Fol. Biol. 2009, 55, 126-131
Total-tau and Phospho-tau(181Thr) in Cerebrospinal Fluid of Neurologically Intact Population Increase with Age
Tau protein is a microtubule-associated molecule playing a crucial role in maintenance of neuronal integrity and in many neurodegenerative processes; its pathology has become a hallmark feature at the tissue level. The aim of the study was to estimate total tau and phospho-tau (Thr181) concentrations in cerebrospinal fluid of healthy population. Cerebrospinal fluid samples were taken from 129 subjects (age 18–77 years) without known neurologic or psychiatric condition. Both total-tau and phosphotau levels showed significant correlation with age, which was more pronounced in older population.
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Funding
This study was supported by grant from the Ministry of Education 2006-2009 No. 2P05B06230.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
