Fol. Biol. 2010, 56, 19-26
https://doi.org/10.14712/fb2010056010019
Polymorphisms of Genes for Brain-Derived Neurotrophic Factor, Methylenetetrahydrofolate Reductase, Tyrosine Hydroxylase, and Endothelial Nitric Oxide Synthase in Depression and Metabolic Syndrome
References
1. 2006) Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet. Med. 23, 469-480.
< , K. G., Zimmet, P., Shaw, J. (https://doi.org/10.1111/j.1464-5491.2006.01858.x>
2. 1999) Neurotrophins and depression. Trends Pharmacol. Sci. 20, 59-61.
< , C. A. (https://doi.org/10.1016/S0165-6147(99)01309-7>
3. American Psychiatric Association (1994) Diagnostic and Statistical Manual for Mental Disorders – Fourth Edition, American Psychiatric Press, Washington, DC.
4. 1997) Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am. J. Med. Genet. 74, 526-528.
< , T., Yamada, N., Yamakawa-Kobayashi, K., Hamaguchi, H., Toru, M. (https://doi.org/10.1002/(SICI)1096-8628(19970919)74:5<526::AID-AJMG14>3.0.CO;2-E>
5. 2001) Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. Mol. Genet. Metab. 73, 188-195.
< , P., Kaňková, K., Mužík, J., Groch, L., Benedík, J., Elbl, L., Izakovičová-Hollá, L., Vašků, A., Znojil, V., Vácha, J. (https://doi.org/10.1006/mgme.2001.3188>
6. 2000) Homocysteine, folate, methylation, and monoamine metabolism in depression. J. Neurol. Neurosurg. Psychiatry 69, 228–232.
< , T., Laundy, M., Crellin, R., Toone, B. K., Carney, M. W., Reynolds, E. H. (https://doi.org/10.1136/jnnp.69.2.228>
7. 2003) 5,10-Methylenetetrahydrofolate reductase 677C→T and 1298A→C mutations are genetic determinants of elevated homocysteine. Q. J. Med. 96, 297-303.
< , R., Rivera, I., Ravasco, P., Jakobs, C., Blom, H. J., Camilo, M. E., De Almeida, I. T. (https://doi.org/10.1093/qjmed/hcg039>
8. 2001) NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch. Physiol. Biochem. 109, 357-360.
< , G. N., Fiore, M., Stankulov, D. V., Hristova, M., Antonelli, A., Manni, L., Ghenev, P. I., Angelucci, F., Aloe, L. (https://doi.org/10.1076/apab.109.4.357.4249>
9. 2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wildtype BDNF in neurosecretory cells and cortical neurons. J. Neurosci. 24, 4401-4411.
< , Z. Y., Patel, P. D., Sant, G., Meng, C. X., Teng, K. K., Hempstead, B. L., Lee, F. S. (https://doi.org/10.1523/JNEUROSCI.0348-04.2004>
10. 2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314, 140-143.
< , Z. Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C. J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., Hempstead, B. L., Lee, F. S. (https://doi.org/10.1126/science.1129663>
11. 2006) Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Res. 1118, 176-182.
< , M. J., Kang, R. H., Lim, S. W., Oh, K. S., Lee, M. S. (https://doi.org/10.1016/j.brainres.2006.08.012>
12. 2004) Decreased plasma nitric oxide metabolites and platelet nitric oxide synthase activity in patients with major depression. Biol. Psychiatry 56, 129-134.
< , W. E., Juracz, P., Radomski, M. W., Lara, N., Archer, S., Le Melledo, J. M. (https://doi.org/10.1016/j.biopsych.2004.03.003>
13. Czech Health Statistics Yearbook 2006, ÚZIS ČR, Prague, Czech Republic (2007).
14. 2004) Depression: a case of neuronal life and death? Biol. Psychiatry 56, 140-145.
< , R. S. (https://doi.org/10.1016/j.biopsych.2004.02.033>
15. 2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch. Gen. Psychiatry 60, 804-815.
< , Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., Pandey, G. N. (https://doi.org/10.1001/archpsyc.60.8.804>
16. 2008) Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants. Schizophr. Res. 98, 47-54.
< , V. L., Miller del, D., Taylor, S. F., Moline, J., Holman, T., Kerr, J. (https://doi.org/10.1016/j.schres.2007.09.030>
17. 2007) The homocysteine hypothesis of depression. Am. J. Psychiatry 164, 861-867.
< , M., Liu, T., Peter, I., Buell, J., Arsenault, L., Scott, T., Qiu, W. W. (https://doi.org/10.1176/ajp.2007.164.6.861>
18. 1999) Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders. Am. J. Med. Genet. 88, 88-94.
< , R. A., Rubinsztein, J. S., Luk, H., Walsh, C., Coleman, T. A., Muir, W. J., Paykel, E. S., Blackwood, D. H. R., Rubinsztein, D. C. (https://doi.org/10.1002/(SICI)1096-8628(19990205)88:1<88::AID-AJMG16>3.0.CO;2-J>
19. 2008) Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. Am. J. Physiol. Endocrinol. Metab. 294, E978-E986.
< , E., Piatti, P., Citterio, L., Lucotti, P. C. G., Setola, E., Cassina, L., Oldani, M., Zavaroni, I., Bosi, E., Colombo, A., Alfieri, O., Casari, G., Reaven, G. M., Monti, L. D. (https://doi.org/10.1152/ajpendo.00003.2008>
20. 2008) Metabolic syndrome pandemic. Arterioscler. Thromb. Vasc. Biol. 28, 629-636.
< , S. M. (https://doi.org/10.1161/ATVBAHA.107.151092>
21. 2006) Significance of hyperhomocysteinemia. Clin. Lab. 52, 367-374.
, W. (
22. 2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48, 186-189.
< , C. J., Huo, S. J., Yen, F. C., Tung, C. L., Pan, G. M., Tsai, S. J. (https://doi.org/10.1159/000074636>
23. 2007) The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 1003-1006.
< , J., Ueno, S., Yamauchi, K., Numata, S., Tayoshi-Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., Sano, A., Ohmori, T. (https://doi.org/10.1002/ajmg.b.30520>
24. 2001) Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Biochem. Biophys. Res. Comm. 284, 426-430.
< , M., Horký, K., Bultas, J., Kožich, V., Jindra, A., Peleška, J., Martásek, P. (https://doi.org/10.1006/bbrc.2001.5007>
25. 2000) Association analysis of two tyrosine hydroxylase gene polymorphisms in normotensive offspring from hypertensive families. Blood Press. 9, 250-254.
< , A., Jáchymová, M., Horký, K., Peleška, J., Umnerová, V., Bultas, J., Šavlíková, J. (https://doi.org/10.1080/080370500448623>
26. 2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 109, 143-148.
< , F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., Aubry, J. M. (https://doi.org/10.1016/S0165-1781(02)00005-7>
27. 2006) Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol. Psychiatry 59, 673-680.
< , J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystala, J. H., Gelernter, J. (https://doi.org/10.1016/j.biopsych.2005.10.026>
28. 2003) Depressed new neurons – adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry 54, 499-503.
< , G., Kronenberg, G. (https://doi.org/10.1016/S0006-3223(03)00319-6>
29. 2007) Distribution of 1298A > C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. Eur. Psychiatry 22, 39-43.
< , B., Bober, A., Łuczak, M., Czerski, P., Szczepankiewicz, A., Hauser, J., Jagodziński, P. P. (https://doi.org/10.1016/j.eurpsy.2006.11.003>
30. 2005) TH01, a tetrameric short tandem repeat locus in the tyrosine hydroxylase gene: association with myocardial hypertrophy and death from myocardial infarction? Dis. Markers 21, 9-13.
< , M., Immel, U. D., Stiller, D., Kleiber, M. (https://doi.org/10.1155/2005/256254>
31. 2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50, 431-438.
< , K. S., Nielsen, A. R., Krogh-Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., Fischer, C., Lindegaard, B., Petersen, A., Taudorf, S., Secher, N., Pilegaard, H., Bruunsgaard, H., Pedersen, B. (https://doi.org/10.1007/s00125-006-0537-4>
32. 2003) Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr. Res. 62, 281-283.
< , H., Nanko, S., Hirasawa, H., Kato, N., Nabika, T., Kobayashi, S. (https://doi.org/10.1016/S0920-9964(02)00349-3>
33. 2004) No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol. Psychiatry 56, 376-378.
< , H., Iijima, Y., Tatsumi, M., Yoshida, M., Hashimoto, R., Kato, T., Sakamoto, K., Fukumada, F., Inada, T., Suzuji, T., Iwata, N., Ozaki, N., Yamada, K., Yoshikawa, T. (https://doi.org/10.1016/j.biopsych.2004.06.017>
34. 2004) Nitric oxide: A key player in the relation between cardiovascular disease and major depressive disorder? J. Psychiatry Neurosci. 29, 414-416.
, J.-M., Mahil, N., Baker, G. B. (
35. 1990) Tyrosine hydroxylase polymorphisms associated with manic-depressive illness. Lancet 335, 1219.
< , M., Malafosse, A., Boularand, S., Campion, D., Gheysen, F., Samolyk, D., Henriksson, B., Denise, E., des Lauriers, A., Lepine, J. P. (https://doi.org/10.1016/0140-6736(90)92738-4>
36. 2004) Gene-environment interaction and the genetics of depression. J. Psychiatry Neurosci. 29, 174-182.
, K. P. (
37. 2007) Neurotrophism and energy homeostasis – perfect together. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R988-R991.
< , B. E. (https://doi.org/10.1152/ajpregu.00434.2007>
38. 2006) The genetics of depression: a review. Biol. Psychiatry 60, 84-92.
< , D. F. (https://doi.org/10.1016/j.biopsych.2005.08.024>
39. 2006) The thermolabile variant of MTHFR is associated with depression in the British Women’s Heart and Health Study and a metaanalysis. Mol. Psychiatry 11, 352-360.
< , S. J., Lawlor, D. A., Davey Smith, G., Araya, R., Timpson, N., Day, I. N. M., Ebrahim, S. (https://doi.org/10.1038/sj.mp.4001790>
40. 2008) Meta-analyses of genetic studies on major depressive disorder. Mol. Psychiatry 13, 772-785.
< , S., Janssens, A. C. J. W., González-Zuloeta Ladd, A. M., Del-Favero, J., Claes, S. J., Oostraand, B. A., van Duijn, C. M. (https://doi.org/10.1038/sj.mp.4002088>
41. 2007) Dietary fat, genes and insulin sensitivity. J. Mol. Med. 85, 213-226.
< , J., Pérez-Martínez, P., Marin, C., Fuentes, F., Delgado, J., Pérez-Jiménez, F. (https://doi.org/10.1007/s00109-006-0138-1>
42. 1991) Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10, 558-568.
< , P. C., Le Beau, M. M., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S., Furth, M. E., Yancopoulos, G. D. (https://doi.org/10.1016/0888-7543(91)90436-I>
43. 2005) Glucocorticoids, depression and mood disorders: structural remodeling in the brain. Metabolism 54 (Suppl 1), 20-23.
< , B. S. (https://doi.org/10.1016/j.metabol.2005.01.008>
44. 1996) A hospital-based twin register of the heritability of DSM-IV unipolar depression. Arch. Gen. Psychiatry 53, 129-136.
< , P., Katz, R., Watkins, S., Rutherford, J. (https://doi.org/10.1001/archpsyc.1996.01830020047006>
45. 1988) A simple salting out extraction DNA from human nucleated cells. Nucleic Acids Res. 16, 1215.
< , S. A., Dykes, D. D., Polesky, H. F. (https://doi.org/10.1093/nar/16.3.1215>
46. 2008) The BDNF Val66Met polymorphism and smoking. Neurosci. Lett. 442, 30-33.
< , C., Basten, U., Stelzel, C., Fiebach, C. J., Reuter, M. (https://doi.org/10.1016/j.neulet.2008.06.064>
47. 1998) The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch. Gen. Psychiatry 55, 580-592.
< , D. L., Evans, D. L., Nemeroff, C. B. (https://doi.org/10.1001/archpsyc.55.7.580>
48. 2003) Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol. Psychiatry 54, 317-329.
< , D. L., Betan, E., Larsen, H., Phillips, L. S. (https://doi.org/10.1016/S0006-3223(03)00569-9>
49. 2002) Neurobiology of depression. Neuron 34, 13-25.
< , E. J., Barrot, M., DiLeone, R. J., Eisch A. J., Gold S. J., Monteggia L. M. (https://doi.org/10.1016/S0896-6273(02)00653-0>
50. 2000) Insulin resistance in patients with depression and its changes during the clinical course of depression: Minimal model analysis. Metabolism 49, 1255-1260.
< , F., Tashiro, A., Utumi, A., Imai, T., Suchi, T., Tamura, D., Sato, Y., Suzuki, S., Hongo, M. (https://doi.org/10.1053/meta.2000.9515>
51. 2007) Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 87, 315-424.
< , P., Beckman, J. S., Liaudet, L. (https://doi.org/10.1152/physrev.00029.2006>
52. Peakall, R., Smouse P. E. (2005) GenAlEx V6: Genetic analysis in Excel. Population genetic software for teaching and research, Australian National University, Canberra. Available via http://www.anu.edu.au/BoZo/GenAlEx.
53. 1992) Dinucleotide repeat polymorphism at the human gene for the brain-derived neurotrophic factor (BDNF). Hum. Mol. Genet. 1, 353.
< , M., Saunders, A., Roses, A. D., Müller, C. R. (https://doi.org/10.1093/hmg/1.5.353-a>
54. 2007) Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation 116, 993-1006.
< , F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., Mahata, S. K., Schork, N. J., Taupenot, L., Ziegler, M. G., O’Connor, D. T. (https://doi.org/10.1161/CIRCULATIONAHA.106.682302>
55. 2002) Metabolic syndrome. Pathophysiology and implications for management of cardiovascular disease. Circulation 106, 286-288.
< , G. M. (https://doi.org/10.1161/01.CIR.0000019884.36724.D9>
56. 2007) The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. NeuroReport 18, 1291-1293.
< , L., Busnello, J. V., Cantor, R. M., Whelan, F., Whittaker, P., Deloukas, P., Wong, M. L., Licinio, J. (https://doi.org/10.1097/WNR.0b013e328273bcb0>
57. 2003) A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28, 397-401.
< , S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., Burmeister, M. (https://doi.org/10.1038/sj.npp.1300053>
58. 2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta analyses and implications. Biol. Psychiatry 64, 527-532.
< , S., Duman, R, Sanacora, G. (https://doi.org/10.1016/j.biopsych.2008.05.005>
59. 1998) Tyrosine hydroxylase gene associated with depressive symptomatology in mood disorder. Am. J. Med. Genet. 8, 127-130.
< , A., Macciardi, F., Verga, M., Cusin, C., Pedrini, S., Smeraldi, E. (https://doi.org/10.1002/(SICI)1096-8628(19980328)81:2<127::AID-AJMG1>3.0.CO;2-T>
60. 2004) Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am. J. Med. Genet. B Neuropsychiatr. Genet. 126, 122-123.
< , E., Hashimoto, K., Iyo, M. (https://doi.org/10.1002/ajmg.b.20118>
61. 2002) Familybased association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus: Brain-derived neurotrophic factor. Mol. Psychiatry 7, 579–593.
< , P., Gabriel, S. B., McInnis, M. G., Bennett, P., Lim, Y. M., Tsan G., Schaffner, S., Kirov, G., Jones, I., Owen, M., Craddock, N., DePaulo J. R., Lander, E. S.(https://doi.org/10.1038/sj.mp.4001058>
62. 2007) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J. Psychiatr. Res. 41, 404-409.
< , P. G., Wainwright, N. W., Willis-Owen, S. A., Sandhu, M. S., Luben, R., Day, N. E., Flint, J. (https://doi.org/10.1016/j.jpsychires.2006.01.004>
63. 2007) Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity? J. Endocrinol. Invest. 30, 747-753.
< , I., Senesi, P., Fermo, I., Lattuada, G., Luzi, L. (https://doi.org/10.1007/BF03350812>
64. 2005) Genetic determinants of folate status in Central Bohemia. Physiol. Res. 54, 295-303.
< , K., Pavlíková, M., Janošíková, B., Anděl, M., Zvárová, J., Hyánek, J., Kožich, V. (https://doi.org/10.33549/physiolres.930602>
65. 1999) A systematic review of the mortality of depression. Psychosom. Med. 61, 6-17.
< , L. R, Vaillant, G. E., Wells, V. E. (https://doi.org/10.1097/00006842-199901000-00003>
66. 2004) Consequences of moderate hyperhomocysteinaemia in internal medicine. Cas. Lek. Cesk. 143, 367-374. (In Czech)
, A., Zeman, M. (
67. 2004) Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiol. Genomics 19, 277-291.
< , L., Rao, F., Wessel, J., Kennedy, B. P., Rana, B. K., Taupenot, L., Lillie, E. O., Cockburn, M., Schork, N. J., Ziegler, M. G., O’Connor, D. T. (https://doi.org/10.1152/physiolgenomics.00151.2004>