Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2010, 56, 72-77

https://doi.org/10.14712/fb2010056020072

Leflunomide Derivate FK 778 in Accelerated Renal Injury in Transgenic Rat

Silvie Bloudíčková1, J. Rajnoch1, A. Lodererová2, E. Honsová2, O. Viklický1

1Department of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
2Department of Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Received July 2009
Accepted December 2009

References

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2. Bloudickova, S., Rajnoch, J., Lodererova, A., Honsova, E., Viklicky, O. (2006) Mycophenolate mofetil ameliorates accelerated progressive nephropathy in rat. Kidney Blood Press. Res. 29, 60-66. <https://doi.org/10.1159/000092948>
3. De Greef, K. E., Ysebaert, D. K., Vercauteren, S. R., Chapelle, T., Roeyen, G., Bosmans, J. L., Verpooten, G. A., De Broe, M. E. (2002) Effect of immunosuppression on damage, leukocyte infiltration, and regeneration after severe warm ischemia/reperfusion renal injury. Transplant. Proc. 34, 791-794. <https://doi.org/10.1016/S0041-1345(01)02912-8>
4. Deuse, T., Schrepfer, S., Reichenspurner, H. (2003) Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation 76, 1627-1629. <https://doi.org/10.1097/01.TP.0000092006.43818.B0>
5. Deuse, T., Schrepfer, S., Schafer, H., Koch-Nolte, F., Schwedhelm, E., Boger, R. H., Reichenspurner, H. (2004) FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 78, 71-77. <https://doi.org/10.1097/01.TP.0000128629.53843.14>
6. Fitzsimmons, W. E., First, M. R. (2004) FK778, a synthetic malononitrilamide. Yonsei Med. J. 45, 1132-1135. <https://doi.org/10.3349/ymj.2004.45.6.1132>
7. Lutz, J., Huang, H., Deng, M., Wagner, B., Roos, M., Schmaderer, C., Strobl, M., Heemann, U. (2007) The effect of FK778 on the progression of chronic allograft nephropathy in a rat model. Transplantation 83, 741-746. <https://doi.org/10.1097/01.tp.0000255558.02582.ce>
8. Pan, F., Ebbs, A., Wynn, C., Ericsson, L., Jang, M. S., Crews, G., Fisniku, O., Kobayashi, M., Paul, L. C., Benediktsson, H., Jiang, A. H. (2003) FK778, a powerful new immunosuppressant, effectively reduces functional and histologic changes of chronic rejection in rat renal allografts. Transplantation 75, 1110-1114. <https://doi.org/10.1097/01.TP.0000063704.19149.E3>
9. Rajnoch, J., Lodererova, A., Szabo, A., Honsova, E., Vannay, A., Bloudickova, S., Matl, I., Viklicky, O. (2005) Regulators of angiogenesis in renal ischemia/reperfusion injury in normotensive and hypertensive rats: effect of tacrolimus. Transplant. Proc. 37, 352-354. <https://doi.org/10.1016/j.transproceed.2004.12.154>
10. Rintala, J. M., Savikko, J., Rintala, S. E., von Willebrand, E. (2006) The effect of leflunomide analogue FK778 on development of chronic rat renal allograft rejection and transforming growth factor-β expression. Transplant. Proc. 38, 3239-3240. <https://doi.org/10.1016/j.transproceed.2006.10.051>
11. Schrepfer, S., Deuse, T., Schafer, H., Reichenspurner, H. (2005) FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival. Transpl. Int. 18, 215-220. <https://doi.org/10.1111/j.1432-2277.2004.00044.x>
12. Schrepfer, S., Deuse, T., Koch-Nolte, F., Detter, C., Reichenspurner, H. (2006) FK778 new cellular and molecular mechanisms of action. Transplant. Proc. 38, 757-761. <https://doi.org/10.1016/j.transproceed.2006.01.058>
13. Viklicky, O., Bohmova, R., Ouyang, N., Honsova, E., Lodererova, A., Mandys, V., Vitko, S., Lutz, J., Hermann U. W. (2004) Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats. Transpl. Int. 17, 432-441.
14. Vu, M. D., Wang, S. Q., Juany, W., Ma, A., Xu, D., Bekersky, I., Fitzsimmons, W. E., Wu, J., Chen, H. (2003) Combination therapy of malonitrilamide FK778 with tacrolimus on cell proliferation assays and in rats receiving renal allografts. Transplantation 75, 1455-1459. <https://doi.org/10.1097/01.TP.0000058811.25785.F4>
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