Fol. Biol. 2010, 56, 110-115

https://doi.org/10.14712/fb2010056030110

Insights into the Role of IL-12B and IFN-γ Cytokine Gene Polymorphisms in HIV-1/AIDS Infection

Ranbir Chander Sobti1, A. M. Salih1, B. Nega1, A. H. Seyed2, K. Rupinder1, K. Vijesh2, W. Ajay2

1Department of Biotechnology, Panjab University, Chandigarh, India
2Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Received July 2009
Accepted November 2009

References

1. Barretina, J., Blanco, J., Gutierrez, A., Puig, L., Altisent, C., Espanol, T., Caragol, I., Clotet, B., Este, J. A. (2000) Evaluation of the putative role of C-C chemokines as protective factors of HIV-1 infection in seronegative hemophiliacs exposed to contaminated hemoderivatives. Transfusion 40, 461-467. <https://doi.org/10.1046/j.1537-2995.2000.40040461.x>
2. Belich, M. P., Glynne, R. J., Senger, G., Sheer, D., Trowsdale, J. (1994) Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr. Biol. 4, 769-776. <https://doi.org/10.1016/S0960-9822(00)00174-3>
3. Boehm, U., Klamp, T., Groot, M., Howard, J. C. (1997) Cel lular responses to interferon-γ. Annu. Rev. Immunol. 15, 749-795. <https://doi.org/10.1146/annurev.immunol.15.1.749>
4. Breen, F. N., Hume, D. A., Weidemann, M. J. (1991) Interactions among granulocyte-macrophage colony-stimulating factor, macrophage colony stimulation factor, and IFNγ lead to enhanced proliferation of murine macrophage progenitor cells. J. Immunol. 147, 1542-1547. <https://doi.org/10.4049/jimmunol.147.5.1542>
5. Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., O’Brien, S. J. (1999) HLA and HIV-1: Heterozygote advantage and B35-Cw04 disadvantage. Science 283, 1748-1752. <https://doi.org/10.1126/science.283.5408.1748>
6. Chehimi, J., Starr, S. E., Frank, I., D’Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J., Trinchieri, G. (1994) Impaired interleukin 1 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179, 1361-1366. <https://doi.org/10.1084/jem.179.4.1361>
7. Clerici, M., Balotta, C., Meroni, L., Ferrario, E., Riva, C., Trabattoni, D., Ridolfo, A., Villa, M., Shearer, G. M., Moroni, M., Galli, M. (1996) Type 1 cytokine production and low prevalence of viral isolation correlate with longterm nonprogression in HIV infection. AIDS Res. Hum. Retroviruses 12, 1053-1061. <https://doi.org/10.1089/aid.1996.12.1053>
8. Coffin, J. M. (1996) HIV viral dynamics. AIDS 10, S75.
9. Decker, T., Stockinger, S., Karaghiosoff, M., Muller, M., Kovarik, P. (2002) IFNs and STATs in innate immunity to microorganisms. J. Clin. Invest. 109, 1271-1277. <https://doi.org/10.1172/JCI0215770>
10. Easterbrook, P. J. (1999) Long-term non-progression in HIV infection: definitions and epidemiological issues. J. Infect. 38, 71-73. <https://doi.org/10.1016/S0163-4453(99)90071-3>
11. Farquhar, C., Rowland-Jones, S., Mbori-Ngacha, D., Redman, M., Lohman, B., Slyker, J., Otieno, P., Obimbo, E., Rostron, T., Ochieng, J., Oyugi J., Bosire, R., John-Stewart, G. (2005) Human leukocyte antigen (HLA) B18 and protection against mother-to-child HIV type 1 transmission. AIDS Res. Hum. Retroviruses 20, 692-697. <https://doi.org/10.1089/0889222041524616>
12. Fowke, K. R., Nagelkerke, N. J., Kimani, J., Simonsen, J. N., Anzala, A. O., Bwavo, J. J., MacDonald, K. S. (1996) Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348, 1347-1351. <https://doi.org/10.1016/S0140-6736(95)12269-2>
13. Gajewski, T. F., J. Renauld. J. C., Van Pel, A., Boon, T. (1995) Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro. J. Immunol. 154, 5637-5648. <https://doi.org/10.4049/jimmunol.154.11.5637>
14. Gately, M. K., Wolitzky, A. G., Quinn, P. M., Chizzonite, R. (1992) Regulation of human cytolytic lymphocyte responses by interleukin-12. Cel. Immunol. 143, 127-169. <https://doi.org/10.1016/0008-8749(92)90011-D>
15. Groettrup, M., Khan, S., Schwarz, K., Schmidtke, G. (2001) Interferon-γ inducible exchanges of 20S proteasome active site subunits. Biochimie 83, 367-372. <https://doi.org/10.1016/S0300-9084(01)01251-2>
16. Huang, D., Cancilla, M. R., Morahan, G. (2000) Complete primary structure, chromosomal localisation, and definition of polymorphism of the gene encoding the human interleukin-12 p40 subunit. Genes Immun. 1, 515-520. <https://doi.org/10.1038/sj.gene.6363720>
17. Hutchinson, I. V., Pravica, V., Hajeer, A., Sinnott, P. J. (1999) Identification of high and low responders to allografts. Rev. Immunogenet. 1, 323-333.
18. Izad, M., Vodjgani, M., Nicknam, M. H., Lotfi, J., Fathi, D., Amirzargar, A. A. (2004) Interferon-γ gene polymorphism in Iranian patients with multiple sclerosis. Iran J. Allergy Asthma Immunol. 3, 115-119.
19. Kang, M.-W., Pyo, C.-W., Wie, S.-H., Choi, H.-B., Kim, S.-Y., Kim, Y.-K., Lee, J.-S., Kim, T.-G. (2006) Associations of IFN-γ polymorphism with HIV-1 infection in the Korean Population. AIDS Res. Hum. Retroviruses 22, 297-299. <https://doi.org/10.1089/aid.2006.22.297>
20. Knight, E. P. (2008) Purification of native interferons. J. Interferon Cytokine Res. 28, 637-638. <https://doi.org/10.1089/jir.2008.2811.hp1>
21. Mach, B., Steimle, V., Martinez-Soria, E., Reith, W. (1996) Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14, 301-331. <https://doi.org/10.1146/annurev.immunol.14.1.301>
22. Marmor, M., Hertzmark. K., Thomas, S. M., P. Halkitis, P. N., Vogler, M. (2006) Resistance to HIV infection. J. Urban Health 83, 1-7. <https://doi.org/10.1007/s11524-005-9003-8>
23. Marshall, J. D., Chehimi, J., Gri, G., Kostman, J. R., Montaner, L. J., Trinchieri, G. (1999) The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. Blood 94, 1003-1011. <https://doi.org/10.1182/blood.V94.3.1003.415a15_1003_1011>
24. McFarland, E. J., Harding. P. A., MaWhinney, S., Schooley, R. T., Kuritzkes.D. R. (1998) In vitro effects of IL-12 on HIV-1-specific CTL lines from HIV-1-infected children. J. Immunol. 161, 513-519. <https://doi.org/10.4049/jimmunol.161.1.513>
25. McNicholl, J. M., Promadej, N. (2004) Insights into the role of host genetic and T-cell factors in resistance to HIV transmission from studies of highly HIV-exposed Thais. Immunol. Res. 29, 161-174. <https://doi.org/10.1385/IR:29:1-3:161>
26. Mellors, J. W., Rinaldo, C. R. Jr., Gupta, P., White, R. M., Todd, J. A., Kingsley, L. A. (1996) Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272, 1167-1170. <https://doi.org/10.1126/science.272.5265.1167>
27. Perrey, C., Turner, S. J., Pravica, V., Howell, W. M., Hutchinson, I. V. (1999) ARMS-PCR methodologies to determine IL-10, TNF-α, TNF-β and TGF-β1 gene polymorphisms. Transpl. Immunol. 7, 127-128. <https://doi.org/10.1016/S0966-3274(99)80030-6>
28. Prabhu Anand, S., Selvaraj, P., Jawahar, M. S., Adhilakshmi, A. R., Narayanan, P. R. (2007) Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosis. Indian J. Med. Res. 126, 135-138.
29. Pravica, V., Perrey, C., Stevens, A., Lee, J. H, Hutchinson, I. V. (2000) A single nucleotide polymorphism in the first intron of the human IFN-γ gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-γ production. Hum. Immunol. 61, 863-869. <https://doi.org/10.1016/S0198-8859(00)00167-1>
30. Saksena, N. K., Rodes, B., Wang, B., Soriano, V. (2007) Elite HIV controllers: myth or reality? AIDS Rev. 9, 195-207.
31. Seegers, D., Zwiers, A., Strober, W., Pena, A. S., Bouma, G. (2002) A TaqI polymorphism in the 3’UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. Genes Immun. 3, 419-423. <https://doi.org/10.1038/sj.gene.6363919>
32. Smith, S. M. (2006) The pathogenesis of HIV infection: stupid may not be so dumb after all. Retrovirology 10, 4690-4693.
33. Timasheva, Y. R., Nasibullin, T. R., Zakirova, A. N., Mustafina, O. E. (2008) Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia. Biochem. Genet. 46, 64-74. <https://doi.org/10.1007/s10528-007-9130-x>
34. Trinchieri, G. (1997) Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol. 9, 17-23. <https://doi.org/10.1016/S0952-7915(97)80154-9>
35. Valdez, H., Lederman, M. M. (1997) Cytokines and cytokine therapies in HIV infection. AIDS Clin. Rev. 98, 187-228.
36. Vasilescu, A., Heath, S. C., Ivanova, R., Hendel, H., Do, H., Mazoyer, A., Khadivpour, E., Goutalier, F. X., Khalili, K., Rappaport, J., Lathrop, G. M., Matsuda, F., Zagury, J. F. (2003) Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: Identification of IL4 and IL10 haplotypes associated with the disease progression. Genes Immun. 4, 441-449. <https://doi.org/10.1038/sj.gene.6363983>
37. Vergis, E. N., Mellors, J. W. (2002) Natural history of HIV-1. Infect. Dis. Clin. North Am. 14, 809-825. <https://doi.org/10.1016/S0891-5520(05)70135-5>
38. Xaus, J., Comalada, M., Valledor, A. F., Cardo, M., Herrero, C., Soler, C., Lloberas, J., Celada, A. (2001) Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis. Immunobiology 204, 543-550. <https://doi.org/10.1078/0171-2985-00091>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive