Reversal of Hypermethylation and Reactivation of the <i>RARβ2</i> Gene by Natural Compounds in Cervical Cancer Cell Lines Cited by

Fol. Biol. 2010, 56, 195-200

https://doi.org/10.14712/fb2010056050195

Reversal of Hypermethylation and Reactivation of the RARβ2 Gene by Natural Compounds in Cervical Cancer Cell Lines

A. K. Jha¹, M. Nikbakht¹, G. Parashar¹, A. Shrivastava², N. Capalash¹, Jagdeep Kaur¹

¹Department of Biotechnology, Panjab University, Chandigarh, India
²Department of Zoology, University of Delhi, Delhi, India

Received July 2010
Accepted September 2010

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Wan Xin, Wang Dong: Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy. Planta Med 2025, 91, 320. <https://doi.org/10.1055/a-2499-1140>
Khatoon Saima, Kalam Nida: Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy. Front. Pharmacol. 2025, 15. <https://doi.org/10.3389/fphar.2024.1531288>
Ghoushi Ehsan, Poudineh Mohadeseh, Parsamanesh Negin, Jamialahmadi Tannaz, Sahebkar Amirhossein: Curcumin as a regulator of Th17 cells: Unveiling the mechanisms. Food Chemistry: Molecular Sciences 2024, 8, 100198. <https://doi.org/10.1016/j.fochms.2024.100198>
Sukhamwang Amonnat, Inthanon Sirinada, Dejkriengkraikul Pornngarm, Semangoen Tistaya, Yodkeeree Supachai: Anti-Cancer Potential of Isoflavone-Enriched Fraction from Traditional Thai Fermented Soybean against Hela Cervical Cancer Cells. IJMS 2024, 25, 9277. <https://doi.org/10.3390/ijms25179277>
Sharan Mahek, Jha Meenakshi, Chandel Rishima, Syeda Saima, Mathur Runjhun, Jha Niraj Kumar, Jha Saurabh Kumar, Goel Harsh, Shrivastava Anju, Chauhan Sushma, Pamidimarri Sudheer, Jha Abhimanyu Kumar: Demethylation of CADM1 and SOCS1 using capsaicin in cervical cancer cell line. Naunyn-Schmiedeberg's Arch Pharmacol 2023, 396, 649. <https://doi.org/10.1007/s00210-022-02340-1>
Nadile Matteo, Kornel Amanda, Sze Newman Siu Kwan, Tsiani Evangelia: A Comprehensive Review of Genistein\u2019s Effects in Preclinical Models of Cervical Cancer. Cancers 2023, 16, 35. <https://doi.org/10.3390/cancers16010035>
Ming Tianqi, Tao Qiu, Tang Shun, Zhao Hui, Yang Han, Liu Maolun, Ren Shan, Xu Haibo: Curcumin: An epigenetic regulator and its application in cancer. Biomedicine & Pharmacotherapy 2022, 156, 113956. <https://doi.org/10.1016/j.biopha.2022.113956>
Kumar Umesh, Sharma Ujjawal, Rathi Garima: Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line. Tumour Biol. 2017, 39. <https://doi.org/10.1177/1010428317692258>
Sharma Vishal, Kaur Ramandeep, Bhatnagar Archana, Kaur Jagdeep: Low-pH-induced apoptosis: role of endoplasmic reticulum stress-induced calcium permeability and mitochondria-dependent signaling. Cell Stress and Chaperones 2015, 20, 431. <https://doi.org/10.1007/s12192-014-0568-6>
Mukherjee Neelam, Kumar Addanki P., Ghosh Rita: DNA Methylation and Flavonoids in Genitourinary Cancers. Curr Pharmacol Rep 2015, 1, 112. <https://doi.org/10.1007/s40495-014-0004-8>
Shukla Samriddhi, Khan Sajid, Kumar Sudhir, Sinha Sonam, Farhan Mohd., Bora Himangsu K., Maurya Rakesh, Meeran Syed Musthapa: Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis. Cancer Prevention Research 2015, 8, 552. <https://doi.org/10.1158/1940-6207.CAPR-14-0286>
Sharma V., Jha A. K., Kumar A., Bhatnagar A., Narayan G., Kaur Jagdeep: Curcumin-Mediated Reversal of p15 Gene Promoter Methylation: Implication in Anti-Neoplastic Action against Acute Lymphoid Leukaemia Cell Line. Fol. Biol. 2015, 61, 81. <https://doi.org/10.14712/fb2015061020081>
Lewinska Anna, Adamczyk Jagoda, Pajak Justyna, Stoklosa Sylwia, Kubis Barbara, Pastuszek Paulina, Slota Ewa, Wnuk Maciej: Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2014, 771, 43. <https://doi.org/10.1016/j.mrgentox.2014.07.001>
Thakur Vijay S., Deb Gauri, Babcook Melissa A., Gupta Sanjay: Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention. AAPS J 2014, 16, 151. <https://doi.org/10.1208/s12248-013-9548-5>
Pudenz Maria, Roth Kevin, Gerhauser Clarissa: Impact of Soy Isoflavones on the Epigenome in Cancer Prevention. Nutrients 2014, 6, 4218. <https://doi.org/10.3390/nu6104218>
Chaneiam Nattawara, Changtam Chatchawan, Mungkongdee Thongperm, Suthatvoravut Umaporn, Winichagoon Pranee, Vadolas Jim, Suksamrarn Apichart, Fucharoen Suthat, Svasti Saovaros: A reduced curcuminoid analog as a novel inducer of fetal hemoglobin. Ann Hematol 2013, 92, 379. <https://doi.org/10.1007/s00277-012-1604-1>
Link Alexander, Balaguer Francesc, Shen Yan, Lozano Juan Jose, Leung Hon-Chiu E., Boland C. Richard, Goel Ajay, Zhu Wei-Guo: Curcumin Modulates DNA Methylation in Colorectal Cancer Cells. PLoS ONE 2013, 8, e57709. <https://doi.org/10.1371/journal.pone.0057709>
Jha Abhimanyu Kumar, Nikbakht Mohsen, Jain Veena, Sehgal Alka, Capalash Neena, Kaur Jagdeep: Promoter hypermethylation of p73 and p53 genes in cervical cancer patients among north Indian population. Mol Biol Rep 2012, 39, 9145. <https://doi.org/10.1007/s11033-012-1787-5>
Tao Kaixiong, Wu Chuanqing, Wu Ke, Li Wei, Han Gaoxiong, Shuai Xiaoming, Wang Guobin: Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. Med Oncol 2012, 29, 107. <https://doi.org/10.1007/s12032-010-9805-8>
Park Lara K., Friso Simonetta, Choi Sang-Woon: Nutritional influences on epigenetics and age-related disease. Proc. Nutr. Soc. 2012, 71, 75. <https://doi.org/10.1017/S0029665111003302>
Stefanska B: Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus \u2013 insights into its mechanisms of action. British J Pharmacology 2012, 166, 2209. <https://doi.org/10.1111/j.1476-5381.2012.01959.x>
Stefanska B, Karlic H, Varga F, Fabianowska\u2010Majewska K, Haslberger AG: Epigenetic mechanisms in anti\u2010cancer actions of bioactive food components \u2013 the implications in cancer prevention. British J Pharmacology 2012, 167, 279. <https://doi.org/10.1111/j.1476-5381.2012.02002.x>
JHA ABHIMANYU KUMAR, NIKBAKHT MOHSEN, JAIN VEENA, CAPALASH NEENA, KAUR JAGDEEP: p16INK4a and p15INK4b gene promoter methylation in cervical cancer patients. Oncology Letters 2012, 3, 1331. <https://doi.org/10.3892/ol.2012.655>
Matsukura Hiroshi, Aisaki Ken-ichi, Igarashi Katsuhide, Matsushima Yuko, Kanno Jun, Muramatsu Masaaki, Sudo Katsuko, Sato Noriko: Genistein promotes DNA demethylation of the steroidogenic factor 1 (SF-1) promoter in endometrial stromal cells. Biochemical and Biophysical Research Communications 2011, 412, 366. <https://doi.org/10.1016/j.bbrc.2011.07.104>
Khor Tin Oo, Huang Ying, Wu Tien-Yuan, Shu Limin, Lee Jonghun, Kong Ah-Ng Tony: Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. Biochemical Pharmacology 2011, 82, 1073. <https://doi.org/10.1016/j.bcp.2011.07.065>