Fol. Biol. 2010, 56, 242-251

https://doi.org/10.14712/fb2010056060242

Apolipoprotein E ε4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study

Dana Horáková1, M. Kýr2,3, E. Havrdová1, O. Doležal1, P. Lelková4, L. Pospíšilová4, N. Bergsland5, M. G. Dwyer5, J. L. Cox5, S. Hussein5, Z. Seidl6, M. Vaněčková6, J. Krásenský6, R. Zivadinov5

1Charles University in Prague, First Faculty of Medicine, Department of Neurology and Center of Clinical Neuroscience, Prague, Czech Republic
2Department of Paediatric Oncology, Faculty Hospital Brno, Brno, Czech Republic
3Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Sciences, Masaryk University, Brno, Czech Republic
4Charles University in Prague, First Faculty of Medicine, Department of Paediatrics, Prague, Czech Republic
5Buffalo Neuroimaging Analysis Center, Department of Neurology, SUNY Buffalo, Buffalo, NY, USA
6Charles University in Prague, First Faculty of Medicine, Department of Radiology, Prague, Czech Republic

Received June 2010
Accepted July 2010

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