Fol. Biol. 2011, 57, 41-46
The Importance of Senescence in Ionizing Radiation-Induced Tumour Suppression
Cellular senescence is a condition of longlasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and upregulation of their receptors are discussed in this review.
Keywords
review, senescence, ionizing radiation, cytokine expression.
Funding
This work was supported by the Ministry of Defence of the Czech Republic (project MO0FVZ0000501) and the Ministry of Education, Youth and Sports of the Czech Republic (project MSM0021620820).
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
