Fol. Biol. 2011, 57, 82-85

https://doi.org/10.14712/fb2011057020082

Pregnancy-Associated Plasma Protein A Polymorphisms in Patients with Risk Pregnancies

A. Germanová1, M. Jáchymová1, A. Germanová1, M. Koucký2, Z. Hájek2, T. Zima1, Marta Kalousová1

1Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic
2Department of Obstetrics and Gynaecology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague, Czech Republic

Received May 2010
Accepted August 2010

Pregnant women are often threatened by hypertension, symptoms of preterm labour, hepatopathy, and other. These complications might be the consequence of genetic factors together with involvement of environmental factors. We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exons 5 and 7 of the pregnancy-associated plasma protein A gene in the studied group consisting of 203 women – 79 pregnant women in time of preterm labour, 24 pregnant women suffering from preeclampsia, and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of the studied groups, which led us to the hypothesis that these polymorphisms are not associated with our studied group of Caucasian origin. However, further studies with a larger group of subjects are needed to confirm our results.

Funding

The study was supported by grants GAUK 258051-41508 and SVV-2010-260512.

References

19 live references