Fol. Biol. 2011, 57, 87-95

https://doi.org/10.14712/fb2011057030087

Unfolded Protein Response Suppresses Cisplatin-Induced Apoptosis via Autophagy Regulation in Human Hepatocellular Carcinoma Cells

R. Chen1, R. Y. Dai2, C. Y. Duan2, Y. P. Liu2, S. K. Chen3, D. M. Yan2, C. N. Chen2, M. Wei4, Hong Li2

1Department of Public Health, Luzhou Medical College, Luzhou, Sichuan, P.R. China
2Department of Biochemistry, Luzhou Medical College, Luzhou, Sichuan, P.R. China
3Department of Biology, Luzhou Medical College, Luzhou, Sichuan, P.R. China
4The Affiliated Hospital of Chinese Traditional Medicine, Luzhou Medical College, Luzhou, Sichuan, P.R. China

Received November 2010
Accepted January 2011

References

1. Apel, A., Herr, I., Schwarz, H., Rodemann, H. P., Mayer, A. (2008) Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res. 68, 1485-1494. <https://doi.org/10.1158/0008-5472.CAN-07-0562>
2. Arrigo, A. P. (2007) The cellular “networking” of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis. Adv. Exp. Med. Biol. 594, 14-26. <https://doi.org/10.1007/978-0-387-39975-1_2>
3. Baehrecke, E. H. (2005) Autophagy: dual roles in life and death? Nat. Rev. Mol. Cell Biol. 6, 505-510. <https://doi.org/10.1038/nrm1666>
4. Boulikas, T., Vougiouka, M. (2004) Recent clinical trials using cisplatin, carboplatin and their combination chemotherapy drugs. Oncol. Rep. 11, 559-595.
5. Carew, J. S., Nawrocki, S. T., Kahue, C. N., Zhang, H., Yang, C., Chung, L., Houghton, J. A., Huang, P., Giles, F. J., Cleveland, J. L. (2007) Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110, 313-322. <https://doi.org/10.1182/blood-2006-10-050260>
6. Chen, N., Karantza-Wadsworth, V. (2009) Role and regulation of autophagy in cancer. Biochim. Biophys. Acta 1793, 1516-1523. <https://doi.org/10.1016/j.bbamcr.2008.12.013>
7. Dai, R. Y., Chen, Y., Fu, J., Dong, L. W., Ren, Y. B., Yang, G. Z., Qian, Y. W., Cao, J., Tang, S. H., Yang, S. L., Wang, H. Y. (2009) p28GANK inhibits endoplasmic reticulum stressinduced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res. 19, 1243-1257. <https://doi.org/10.1038/cr.2009.104>
8. Ding, W. X., Ni, H. M., Gao, W., Hou, Y. F., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z. M., Yin, X. M. (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J. Biol. Chem. 282, 4702-4710. <https://doi.org/10.1074/jbc.M609267200>
9. Garrido, C., Ottavi, P., Fromentin, A., Hammann, A., Arrigo, A. P., Chauffert, B., Mehlen, P. (1997) HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res. 57, 2661-2667.
10. Gething, M. J., Sambrook, J. (1992) Protein folding in the cell. Nature 355, 33-45. <https://doi.org/10.1038/355033a0>
11. Gosepath, E. M., Weykam, S., Wiese, M., Kassack, M. U. (2005) Identification of new genes involved in cisplatin resistance and their expression profile in 18 human tumor cell lines. Int. J. Clin. Pharmacol. Ther. 43, 579-580. <https://doi.org/10.5414/CPP43579>
12. Gupta, S., Deepti, A., Deegan, S., Lisbona, F., Hetz, C., Samali, A. (2010) HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1 α-XBP1 signaling through a physical interaction. PLoS Biol. 8, e1000410. <https://doi.org/10.1371/journal.pbio.1000410>
13. Hara, S., Nakashiro, K., Goda, H., Hamakawa, H. (2008) Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells. Biochem. Biophys. Res. Commun. 370, 123-128. <https://doi.org/10.1016/j.bbrc.2008.03.042>
14. Harding, H. P., Zhang, Y., Ron, D. (1999) Protein translation and folding are coupled by an endoplasmic reticulum resident kinase. Nature 397, 271-274. <https://doi.org/10.1038/16729>
15. Harding, H. P., Calfon, M., Urano, F., Novoa, I., Ron, D. (2002) Transcriptional and translational control in the mammalian unfolded protein response. Annu. Rev. Cell Dev. Biol. 18, 575-599. <https://doi.org/10.1146/annurev.cellbio.18.011402.160624>
16. Hendershot, L. M. (2004) The ER function BiP is a master regulator of ER function. Mt. Sinai J. Med. 71, 289-297.
17. Hu, P., Han, Z., Couvillon, A. D., Exton, J. H. (2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J. Biol. Chem. 279, 49420-49429. <https://doi.org/10.1074/jbc.M407700200>
18. Lanneau, D., de Thonel, A., Maurel, S., Didelot, C., Garrido, C. (2007) Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27. Prion 1, 53-60. <https://doi.org/10.4161/pri.1.1.4059>
19. Levine, B., Klionsky, D. J. (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477. <https://doi.org/10.1016/S1534-5807(04)00099-1>
20. Li, J., Lee, A. S. (2006) Stress induction of GRP78/BiP and its role in cancer. Curr. Mol. Med. 6, 45-54. <https://doi.org/10.2174/156652406775574523>
21. Lum, J. J., DeBerardinis, R. J., Thompson, C. B. (2005) Autophagy in metazoans: cell survival in the land of plenty. Nat. Rev. Mol. Cell Biol. 6, 439-448. <https://doi.org/10.1038/nrm1660>
22. Mandic, A., Hansson, J., Linder, S., Shoshan, M. C. (2003) Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J. Biol. Chem. 278, 9100-9106. <https://doi.org/10.1074/jbc.M210284200>
23. Mori, K. (2000) Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101, 451-454. <https://doi.org/10.1016/S0092-8674(00)80855-7>
24. Ogata, M., Hino, S., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback, J. A., Urano, F., Imaizumi, K. (2006) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell Biol. 26, 9220-9231. <https://doi.org/10.1128/MCB.01453-06>
25. Pérez-Tomás, R. (2006) Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr. Med. Chem. 13, 1859-1876. <https://doi.org/10.2174/092986706777585077>
26. Peyrou, M., Hanna, P. E., Cribb, A. E. (2007) Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol. Sci. 99, 346-353. <https://doi.org/10.1093/toxsci/kfm152>
27. Rutkowski, D. T., Kaufman, R. J. (2004) A trip to the ER: coping with stress. Trends Cell Biol. 14, 20-28. <https://doi.org/10.1016/j.tcb.2003.11.001>
28. Schröder, M., Kaufman, R. J. (2005) ER stress and the unfolded protein response. Mutat. Res. 569, 29-63. <https://doi.org/10.1016/j.mrfmmm.2004.06.056>
29. Spangenberg, H. C., Thimme, R., Blum, H. E. (2009) Targeted therapy for hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 6, 423-432. <https://doi.org/10.1038/nrgastro.2009.86>
30. Tsuruo, T., Naito, M., Tomida, A., Fujita, N., Mashima, T., Sakamoto, H., Haga, N. (2003) Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci. 94, 15-21. <https://doi.org/10.1111/j.1349-7006.2003.tb01345.x>
31. Wachsberger, P. R., Landry, J., Storck, C., Davis, K., O’Hara, M. D., Owen, C. S., Leeper, D. B., Coss, R. A. (1997) Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin. Int. J. Hyperthermia 13, 251-255. <https://doi.org/10.3109/02656739709023533>
32. Wakamatsu, T., Nakahashi, Y., Hachimine, D., Seki, T., Okazaki, K. (2007) The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. Int. J. Oncol. 31, 1465-1472.
33. Wang, D, Lippard, S. J. (2005) Cellular processing of platinum anticancer drugs. Nat. Rev. Drug. Discov. 4, 307-320. <https://doi.org/10.1038/nrd1691>
34. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., Mori, K. (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891. <https://doi.org/10.1016/S0092-8674(01)00611-0>
35. Yoshikawa, M., Ono, N., Yodono, H., Ichida, T., Nakamura, H. (2008) Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma. Hepatol. Res. 38, 474-483. <https://doi.org/10.1111/j.1872-034X.2008.00338.x>
36. Zhang, L. J., Li, Z. Q., Yang, Y. P., Li, X. W., Ji, J. F. (2009) Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export. Mol. Cell Biochem. 327, 171-182. <https://doi.org/10.1007/s11010-009-0055-z>
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