Fol. Biol. 2011, 57, 145-150

https://doi.org/10.14712/fb2011057040145

The Influence of Vascular Endothelial Growth Factor (VEGF) Polymorphism on the Progression of Chronic Glomerulonephritides

Hana Šafránková1,2, M. Merta1,2,3, J. Reiterová1,2, J. Štekrová2, D. Maixnerová1, R. Ryšavá1, J. Skibová4, V. Tesař1

1Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
2Institute of Biology and Human Genetics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
3Department of Gerontology and Metabolism, University Hospital Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
4Department of Medical Statistics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Received October 2010
Accepted December 2010

Vascular endothelial growth factor is an important mediator in maintaining normal kidney functions. In addition, several lines of evidence show that up-regulation of this mediator in glomeruli may be associated with or may directly cause renal dysfunction. We tried to assess the influence of the -2578 C/A and -1154 G/A polymorphisms in the regulatory region of the vascular endothelial growth factor gene upon progression of three primary chronic glomerulonephritides (minimal change disease/focal and segmental glomerulosclerosis, membranous nephropathy, immunoglobulin A nephropathy). We studied a cohort of 213 patients compared to 311 unrelated healthy controls. Analysis of the C/A polymorphism of vascular endothelial growth factor revealed an increased prevalence of CC genotype in the minimal change disease/focal and segmental glomerulosclerosis group in comparison with the other groups. A balanced distribution of G and A alleles among the respective types of chronic glomerulonephritides was shown in the analysis of -1154 G/A polymorphism. Finally, we have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis.

Funding

This study was supported by projects IGA MZ CR NR/9523-3 and IGA MZ CR NS/9779-4.

References

20 live references