Fol. Biol. 2011, 57, 200-205

https://doi.org/10.14712/fb2011057050200

Mitoxantrone in Combination with a DNA-PK Inhibitor: Possible Therapy of Promyelocytic Leukaemia Resistant Forms

V. Mikusová1, A. Tichý1, M. Řezáčová2, Jiřina Vávrová1

1Department of Radiobiology, Faculty of Military Health Sciences in Hradec Králové, University of Defence in Brno, Hradec Králové, Czech Republic
2Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic

Received March 2011
Accepted May 2011

References

1. Abuzeid, W. M., Jiang, X., Shi, G., Wang, H., Paulson, D. (2009) Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy. J. Clin. Invest. 119, 1974-1985. <https://doi.org/10.1172/JCI33816>
2. Ader, I., Muller, C., Bonnet, J., Favre, G., Cohen-Jonathan, E., Salles, B., Toulas, C. (2002) The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit. Oncogene 21, 6471-6479. <https://doi.org/10.1038/sj.onc.1205838>
3. Bekker-Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bartek, J., Lukas, J. (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206. <https://doi.org/10.1083/jcb.200510130>
4. Bentle, M. S., Reinicke, K. E., Dong, Y., Bey, E. A., Boothman, D. A. (2007) Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, β-lapachone. Cancer Res. 67, 6936-6945. <https://doi.org/10.1158/0008-5472.CAN-07-0935>
5. Chin, C., Bae, J. H., Kim, M. J., Hwang, J. Y., Kim, S. J., Yoon, M. S., Lee, M. K., Kim, D. W., Chung, B. S., Kang, C. D., Kim, S. H. (2005) Radiosensitization by targeting radioresistance-related genes with protein kinase A inhibitor in radioresistant cancer cells. Exp. Mol. Med. 37, 608-618. <https://doi.org/10.1038/emm.2005.74>
6. Dartsch, D. C., Gieseler, F. (2007) Repair of idarubicin-induced DNA damage: a cause of resistance? DNA Repair (Amst) 6, 1618-1628. <https://doi.org/10.1016/j.dnarep.2007.05.007>
7. Ewald, B., Sampath, D., Plunkett, W. (2008) ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res. 68, 7947-7955. <https://doi.org/10.1158/0008-5472.CAN-08-0971>
8. Falck, J., Coates, J., Jackson, S. P. (2005) Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611. <https://doi.org/10.1038/nature03442>
9. Harker, W. G., Slade, D. L., Dalton, W. S., Meltzer, P. S., Trent, J. M. (1989) Multidrug resistance in mitoxantroneselected HL-60 leukemia cells in the absence of P-glycoprotein overexpression. Cancer Res. 49, 4542-4549.
10. Harker, W. G., Slade, D. L., Parr, R. L., Feldhoff, P. W., Sullivan, D. M., Holguin, M. H. (1995) Alterations in the topoisomerase II α gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II β enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line. Cancer Res. 55, 1707-1716.
11. Hisatomi T., Sueoka-Aragane N., Sato A., Tomimasu R., Ide M., Kurimasa A., Okamoto K., Kimura S., Sueoka E. (2011) NK314 potentiates anti-tumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{α} and DNA-dependent protein kinase. Blood 117, 3575-3584. <https://doi.org/10.1182/blood-2010-02-270439>
12. Kim, M. J., Kim, H. B., Bae, J. H., Lee, J. W., Park, S. J., Kim, D. W., Park, S. I., Kang, C. D., Kim, S. H. (2009) Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway. Biochem. Pharmacol. 78, 573-582. <https://doi.org/10.1016/j.bcp.2009.05.016>
13. Klener, P. (1996) Anti-cancer Chemotherapy. Galén, Praha (In Czech) (ISBN 80-85824-36-1)
14. Muñoz, P., Baus, F., Piette, J. (2001) Ku antigen is required to relieve G2 arrest caused by inhibition of DNA topoisomerase II activity by the bisdioxopiperazine ICRF-193. Oncogene 20, 1990-1999. <https://doi.org/10.1038/sj.onc.1204262>
15. Shen, H., Schultz, M., Kruh, G. D., Tew, K. D. (1998) Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochim. Biophys. Acta 1381, 131-138. <https://doi.org/10.1016/S0304-4165(98)00020-8>
16. Veuger, S. J., Curtin, N. J., Richardson, C. J., Smith, G. C., Durkacz, B. W. (2003) Radio-sensitization and DNA repair inhibition by the combined use of novel inhibitors of DNAdependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 63, 6008-6015.
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