Fol. Biol. 2012, 58, 98-105
https://doi.org/10.14712/fb2012058030098
Activation of the Jak/Stat Signalling Pathway by Leukaemia Inhibitory Factor Stimulates Trans-differentiation of Human Non-Endocrine Pancreatic Cells into Insulin-Producing Cells
References
1. , A., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., Hrabe de Angelis, M., Lendahl, U., Edlund, H. (1999) Notch signalling controls pancreatic cell differentiation. Nature 26, 877-881.
<https://doi.org/10.1038/23716>
2. , F., Czernichow, P., Scharfmann, R. (1997) Expression of neuronal traits in pancreatic β-cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer. J. Biol. Chem. 3, 1929-1934.
<https://doi.org/10.1074/jbc.272.3.1929>
3. , L., De Breuck, S., Lardon, J., Mfopou, J. K., Rooman, I., Bouwens, L. (2005) In vitro generation of insulin-producing β-cells from adult exocrine pancreatic cells. Diabetologia 48, 49-57.
<https://doi.org/10.1007/s00125-004-1606-1>
4. , L., Bonné, S., German, M. S., Ravassard, P., Heimberg, H., Bouwens, L. (2006) Ngn3 expression during postnatal in vitro β-cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ. 13, 1892-1899.
<https://doi.org/10.1038/sj.cdd.4401883>
5. , L., Bouwens, L. (2008) Can β-cells be derived from exocrine pancreas? Diabetes Obes. Metab. 10, 170-178.
<https://doi.org/10.1111/j.1463-1326.2008.00949.x>
6. , A., Rosenberg, L. (2007) Prospects and challenges for islet regeneration as a treatment for diabetes: a review of islet neogenesis associated protein. J. Diabetes Sci. Technol. 1, 231-244.
<https://doi.org/10.1177/193229680700100214>
7. , Y., Nomura, M., Tanaka, K., Kondo, A., Morinaga, H., Okabe, T., Yanase, T., Nawata, H., Takayanagi, R., Li, E. (2007) Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets. Dev. Dyn. 236, 2865-2874.
<https://doi.org/10.1002/dvdy.21303>
8. , M. O., Torban, E., Jasmin, S. B., Theriault, F. M., German, M. S., Stifani, S. (2003) Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. Mol. Cell. Biol. 23, 6922-6935.
<https://doi.org/10.1128/MCB.23.19.6922-6935.2003>
9. , M., Kim, S. K., St Jacques, B., McMahon, A. P., Melton, D. A. (2000) Regulation of pancreas development by hedgehog signaling. Development 127, 4905-4913.
<https://doi.org/10.1242/dev.127.22.4905>
10. , S. K., Hebrok, M. Intercellular signals regulating pancreas development and function. (2001) Genes Dev. 15, 111-127.
<https://doi.org/10.1101/gad.859401>
11. , A. M., Lipsett, M., Sladek, R., Laganière, S., Hanley, S., Rosenberg, L. (2005) Morphogenetic plasticity of adult human pancreatic islets of Langerhans. Cell Death Differ. 12, 702-712.
<https://doi.org/10.1038/sj.cdd.4401617>
12. , R., Ohtsuka, T., Kobayashi, T. (2007) The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development 134, 1243-1251.
<https://doi.org/10.1242/dev.000786>
13. , J. C., Smith, S. B., Watada, H., Lin, J., Scheel, D., Wang, J., Mirmira, R. G., German, M. S. (2001) Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50, 928-936.
<https://doi.org/10.2337/diabetes.50.5.928>
14. , E., Bottino, R., Lehmann, R., Alejandro, R., Inveradi, L., Ricordi, C. (1997) Improved human islet isolation using a new enzyme blend, liberase. Diabetes 46, 1120-1123.
<https://doi.org/10.2337/diab.46.7.1120>
15. , L. C., Stanger, B. Z., Kwan, K. M., Melton, D. A. (2003) Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl. Acad. Sci. USA 9, 14920-14925.
<https://doi.org/10.1073/pnas.2436557100>
16. , K., Liu, Y., Xu, L., Ikeda, T., Akiyama, T., Noguchi, N., Kawaguchi, S., Yamauchi, A., Takahashi, I., Shervani, N. J., Onogawa, T., Takasawa, S., Okamoto, H. (2004) Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. Gene 29, 161-170.
<https://doi.org/10.1016/j.gene.2004.06.010>
17. , G. L., Taylor-Fishwick, D. A., Johns, R. H., Burcus, N., Kosuri, S., Vinik, A. I. (2007) Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs. Pancreas 34, 103-111.
<https://doi.org/10.1097/01.mpa.0000240609.56806.43>
18. , L., Lipsett, M., Yoon, J. W., Prentki, M., Wang, R., Jun, H. S., Pittenger, G. L., Taylor-Fishwick, D., Vinik, A. I. (2004) A pentadecapeptide fragment of islet neogenesisassociated protein increases β-cell mass and reverses diabetes in C57BL/6J mice. Ann. Surg. 240, 875-884.
<https://doi.org/10.1097/01.sla.0000143270.99191.10>
19. , S., Fang, Z., Yu, X., Zhang, M. (2009) Transcription factors involved in glucose-stimulated insulin secretion of pancreatic β-cells. Biochem. Biophys. Res. Commun. 10, 401-404.
<https://doi.org/10.1016/j.bbrc.2009.04.135>
20. , D. A., Shi, W., Pittenger, G. L., Vinik, A. I. (2006) PDX-1 can repress stimulus-induced activation of the INGAP promoter. J. Endocrinol. 188, 611-621.
<https://doi.org/10.1677/joe.1.06108>
21. , J., García-Hurtado, J., Moran, I., Maestro, M. A., Xu, X., Van de Casteele, M., Skoudy, A. L., Palassini, M., Heimberg, H., Ferrer, J. (2010) Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing β-cells to adopt a neural gene activity program. Genome Res. 6, 722-732.
<https://doi.org/10.1101/gr.101709.109>
22. , T., Yonemura, Y., Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama, K., Moriizumi, S., Unno, M., Tanaka, O., Kondo, H. (1994) Pancreatic β-cell replication and amelioration of surgical diabetes by Reg protein. Proc. Natl. Acad. Sci. USA 26, 3589-3592.
<https://doi.org/10.1073/pnas.91.9.3589>
23. , H., Ables, E. T., Pope, C. F., Washington, M. K., Hipkens, S., Means, A. L., Path, G., Seufert, J., Costa, R. H., Leiter, A. B., Magnuson, M. A., Gannon, M. (2009) Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech. Dev. 126, 958-973.
<https://doi.org/10.1016/j.mod.2009.09.006>
