Fol. Biol. 2012, 58, 157-165

https://doi.org/10.14712/fb2012058040157

Vitamin E Treatment Enhances Erythrocyte Deformability in Aged Rats

Vural Kucukatay1, M. Bor-Kucukata1, G. Gundogdu1, G. Erken2, T. O. Ozcan1, F. D. Miloglu3, Y. Kadioglu3

1Pamukkale University, Faculty of Medicine, Department of Physiology, Kınıklı, Denizli/Turkey
2Balıkesir University, Faculty of Medicine, Department of Physiology, Balıkesir /Turkey
3Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey

Received January 2012
Accepted April 2012

References

1. Ajmani, R. S., Metter, E. J., Jaykumar R., Ingram, D. K., Spangler, E. L., Abugo, O. O., Rifkind, J. M. (2000) Hemodynamic changes during aging associated with cerebral blood flow and impaired cognitive function. Neurobiol. Aging 21, 257-29. <https://doi.org/10.1016/S0197-4580(00)00118-4>
2. Ajmani, R. S., Rifkind, J. M. (1998) Hemorheological changes during human aging. Gerontology 44, 111-10. <https://doi.org/10.1159/000021993>
3. Aydogan, S., Yapislar, H., Artis, S., Aydogan, B. (2008) Impaired erythrocytes deformability in H(2)O(2)-induced oxidative stress: protective effect of L-carnosine. Clin. Hemorheol. Microcirc. 39, 93-98. <https://doi.org/10.3233/CH-2008-1072>
4. Baskurt, O. K., Temiz, A., Meiselman, H. J. (1998) Effect of superoxide anions on red blood cell rheologic properties. Free Radic. Biol. Med. 24, 102-110. <https://doi.org/10.1016/S0891-5849(97)00169-X>
5. Baskurt, K., Meiselman, H. J. (2003) Blood rheology and hemodynamics. Semin. Thromb. Hemost. 29, 435-450.
6. Ben Hamida, C., Doerflinger, N., Belal, S., Linder, C., Reutenauer, L., Dib, C., Gyapay, G., Vignal, A., Le Paslier, D., Cohen, D. (1993) Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nat. Genet. 5, 195-200. <https://doi.org/10.1038/ng1093-195>
7. Carr, A. C., Frei, B. (1999) Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am. J. Clin. Nutr. 69, 1086-1107. <https://doi.org/10.1093/ajcn/69.6.1086>
8. Cheng, H. C., Chan, C. M., Tsay, H. S., Liang, H. J., Liang, Y. C., Liu, D. Z. (2007) Improving effects of epigallocatechin-3-gallate on hemorheological abnormalities of aging Guinea pigs. Circ. J. 71, 597-603. <https://doi.org/10.1253/circj.71.597>
9. Chong-Han, K. (2010) dietary lipophilic antioxidants: implications and significance in the aging process. Crit. Rev. Food. Sci. Nutr. 50, 931-937. <https://doi.org/10.1080/10408390903044073>
10. Christy, R. M., Baskurt, O. K., Gass, G. C., Gray, A. B., Marshall-Gradisnik, S. M. (2010) Erythrocyte aggregation and neutrophil function in an aging population. Gerontology 56, 175-180. <https://doi.org/10.1159/000242461>
11. Coppola, L., Caserta, F., de Lucia, D., Guastafierro, S., Grassia, A., Coppola, A., Marfella, R., Varricchio, M. (2000) Blood viscosity and aging. Arch. Gerontol. Geriatr. 31, 35-42. <https://doi.org/10.1016/S0167-4943(00)00063-7>
12. Delp, M. D., Evans, M. V., Duan, C. (1998) Effects of aging on cardiac output, regional blood flow, and body composition in Fischer-344 rats. J. Appl. Physiol. 85, 1813-1822. <https://doi.org/10.1152/jappl.1998.85.5.1813>
13. Demirkaya, F., Kadioglu, Y. (2007) Simple GC-FId method development and validation for determination of α-tocopherol (vitamin E) in human plasma. J. Biochem. Biophys. Methods 70, 363-368. <https://doi.org/10.1016/j.jbbm.2006.08.006>
14. Donato, A. J., Uberoi, A., Wray, D. W., Nishiyama, S., Lawrenson, L. Richardson, R. S. (2006) differential effects of aging on limb blood flow in humans. Am. J. Physiol. Heart Circ. Physiol. 290, H272-278. <https://doi.org/10.1152/ajpheart.00405.2005>
15. Erel, O. (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. Clin. Biochem. 37, 112-119. <https://doi.org/10.1016/j.clinbiochem.2003.10.014>
16. Erel, O. (2005) A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 38, 1103-1111. <https://doi.org/10.1016/j.clinbiochem.2005.08.008>
17. Fowkes, F. G. R., Lowe, G. D. O., Rumley, A., Lennie, S. E., Smith, F. B., Donnan, P. T. (1993) The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years. Eur. Heart J. 14, 597–601. <https://doi.org/10.1093/eurheartj/14.5.597>
18. Fu, A., Nair, K. S. (1998) Age effect on fibrinogen and albumin synthesis in humans. Am. J. Physiol. 275, 1023-1030.
19. Gerschman, R., Gilbert, D. L., Nye, S. W., Dwyer, P., Fenn, W. O. (1954) Oxygen poisoning and x-irradiation: a mechanism in common. Science 119, 623-626. <https://doi.org/10.1126/science.119.3097.623>
20. Goi, G., Cazzola, R., Tringali, C., Massaccesi, L., Volpe, S. R., Rondanelli, M., Ferrari, E., Herrera, C. J., Cestaro, B., Lombardo, A., Venerando, B. (2005) Erythrocyte membrane alterations during ageing affect β-d-glucuronidase and neutral sialidase in elderly healthy subjects. Exp. Gerontol. 40, 219-225. <https://doi.org/10.1016/j.exger.2004.08.013>
21. Hacioglu, G., Yalcin, O., Bor-Kucukatay, M., Ozkaya, G., Baskurt, O. K. (2002) Red blood cell rheological properties in various rat hypertension models. Clin. Hemorheol. Microcirc. 26, 27-32.
22. Hardeman, M. R., Goedhart, P. T., Dobbe, J. G., Lettinga, K. P. (1994) Laser-assisted optical rotational cell analyzer (LORCA): a new instrument for measurement of various structural hemorhelogical parameters. Clin. Hemorheol. 14, 605-618.
23. Hardeman, M. R., Dobbe, J. G., Ince, C. (2001) The laser-assisted optical rotational cell analyzer (LORCA) as red blood cell aggregometer. Clin. Hemorheol. Microcirc. 25, 1-11.
24. Harma, M., Harma, M., Kocyigit, A., Erel, O. (2005) Increased DNA damage in patients with complete hydatidiform mole. Mutat. Res. 583, 49-54. <https://doi.org/10.1016/j.mrgentox.2005.01.014>
25. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. Gerontol. J. 11, 298-300. <https://doi.org/10.1093/geronj/11.3.298>
26. Ingold, K. U., Webb, A. C., Witter, D., Burton, G. W., Metcalfe, T. A., Muller, D. P. (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch. Biochem. Biophys. 259, 224-225. <https://doi.org/10.1016/0003-9861(87)90489-9>
27. Jin, K. (2010) Modern biological theories of aging. Aging Dis. 1, 72-74.
28. Jin, X., Satoh-Otonashi, Y., Zamami, Y., Hobara, N., Koyama, T., Sun, P., Li, S., Kitamura, Y., Kawasaki, H. (2009) Agerelated disappearance of the inhibitory effect of vascular endothelium on agonist-induced vasoconstriction in rat mesenteric vascular beds. J. Pharmacol. Sci. 111, 372-380. <https://doi.org/10.1254/jphs.09183FP>
29. Judkiewicz, L., Ciszewski, R., Bartosz, G. (1988) The effect of donor age on the packing susceptibility of erythrocytes. Mech. Ageing Dev. 46, 83-87. <https://doi.org/10.1016/0047-6374(88)90116-9>
30. Katherine, A. S., Thomas, P., LaBerge, W., Thomas, J. (1997) In vivo oxidative modification of erythrocyte membrane proteins in copper deficiency. Free Radic. Biol. Med. 22, 835-842.
31. Kim, Y. K., Kwon, E. H., Kim, D. H., Won, D. I., Shin, S., Suh, J. S. (2008) Susceptibility of oxidative stress on red blood cells exposed to gamma rays: hemorheological evaluation. Clin. Hemorheol. Microcirc. 40, 315-324. <https://doi.org/10.3233/CH-2008-1144>
32. Konstantinova, E., Tolstaya, T., Prishchep, S., Milutin, A., Mironova, E., Ivanova, L. (2004) Plasma lipid levels, blood rheology, platelet aggregation, microcirculation state and oxygen transfer to tissues in young and middle-aged healthy people. Clin. Hemorheol. Microcirc. 30, 443-448.
33. Kovács, A., Szikszai, Z., Várady, E., Imre, S. (2006) Study on the hemorheological parameters of oldest-old residents in the East-Hungarian city, Debrecen. Clin. Hemorheol. Microcirc. 35, 83-88.
34. Kucukatay, V., Ağar, A., Gumuslu, S., Yargiçoğlu, P. (2007) Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: relation to oxidant stress and antioxidant enzymes. Int. J. Neurosci. 117, 1091-1107. <https://doi.org/10.1080/00207450600934531>
35. Kucukatay, V., Erken, G., Bor-Kucukatay, M., Kocamaz, E. (2009) Effect of sulfite treatment on erythrocyte deformability in young and aged rats. Toxicol. Mech. Methods 19, 19-23. <https://doi.org/10.1080/15376510802175788>
36. Kumaran, V. S., Arulmathi, K., Srividhya, R., Kalaiselvi, P. (2008) Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats. Exp. Gerontol. 43, 176-83. <https://doi.org/10.1016/j.exger.2007.10.017>
37. Kumaran, V. S., Arulmathi, K., Kalaiselvi, P. (2009) Senescence mediated redox imbalance in cardiac tissue: Antioxidant rejuvenating potential of green tea extract. Nutrition 25, 847-854. <https://doi.org/10.1016/j.nut.2009.02.005>
38. Lowe, G. D., Rumley, A., Whincup, P. H., Danesh, J. (2002) Hemostatic and rheological variables and risk of cardiovascular disease. Semin. Vasc. Med. 2, 429-439. <https://doi.org/10.1055/s-2002-36771>
39. Meister, A. (1992) On the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol. 44, 1905-1915. <https://doi.org/10.1016/0006-2952(92)90091-V>
40. Misra, H. P., Fridovich, I. (1972) The generation of superoxide radical during the autoxidation of hemoglobin. J. Biol. Chem. 10, 6960-6962. <https://doi.org/10.1016/S0021-9258(19)44679-6>
41. Mohandas, N., Shohet, S. B. (1981) The role of membrane-associated enzymes in regulation of erythrocyte shape and deformability. Clin. Haematol. 10, 223-237. <https://doi.org/10.1016/S0308-2261(21)00217-4>
42. Papet, I., Dardevet, D., Sornet, C., Béchereau, F., Prugnaud, J., Pouyet, C., Obled, C. (2003) Acute phase protein levels and thymus, spleen and plasma protein synthesis rates differ in adult and old rats. J. Nutr. 133, 215-219. <https://doi.org/10.1093/jn/133.1.215>
43. Rabini, R. A., Petruzzi, E., Staffolani, R., Tesei, M., Fumelli, P., Pazzagli, M., Mazzanti, L. (1997) diabetes mellitus and subjects’ ageing: a study on the ATP content and ATP-related enzyme activities in human erythrocytes. Eur. J. Clin. Invest. 27, 327-332. <https://doi.org/10.1046/j.1365-2362.1997.1130652.x>
44. Rajasekaran, N. S., Devaraj, H., Devaraj, S. N. (2002) The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver. Nutr. Biochem. 13, 302-306. <https://doi.org/10.1016/S0955-2863(01)00223-6>
45. Rifkind, J. M., Ajmani, R. S., Heim, J. (1997) Impaired hemorheology in the aged associated with oxidative stress. Adv. Exp. Med. Biol. 428, 7-13. <https://doi.org/10.1007/978-1-4615-5399-1_2>
46. Rifkind, J. M., Abugo, O. O., Peddada, R. R., Patel, N., Speer, D., Balagopalakrishna, C., Danon, D., Ingram, D. K., Spangler, E. L. (1999) Maze learning impairment is associated with stress hemopoiesis induced by chronic treatment of aged rats with human recombinant erythropoietin. Life Sci. 64, 237-247. <https://doi.org/10.1016/S0024-3205(98)00559-1>
47. Rimbach, G., Minihane, A. M., Majewicz, J., Fischer, A., Pallauf, J., Virgli, F., Weinberg, P. D. (2002) Regulation of cell signalling by vitamin E. Proc. Nutr. Soc. 61, 415-425. <https://doi.org/10.1079/PNS2002183>
48. Schuitemaker, G. E., Dinant, G. J., van der Pol, G. A., van Wersch, J. W. (2004) Fibrinogen levels in hypercholesterolemic smokers and non-smokers in relation to age and gender. Clin. Exp. Med. 3, 231-235. <https://doi.org/10.1007/s10238-004-0030-7>
49. Seals, D. R., Jablonski, K. L., Donato, A. J. (2011) Aging and vascular endothelial function in humans. Clin. Sci. (Lond). 120, 357-375. <https://doi.org/10.1042/CS20100476>
50. Secomb, T. W., Hsu, R. (1997) Resistance to blood flow in nonuniform capillaries. Microcirculation 4, 421-427. <https://doi.org/10.3109/10739689709146806>
51. Sentürk, U. K., Gündüz, F., Kuru, O., Aktekin, M. R., Kipmen, D., Yalçin, O., Bor-Küçükatay, M., Yeşilkaya, A., Başkurt, O. K. (2001) Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise-trained rats. J. Appl. Physiol. 91, 1999-2004. <https://doi.org/10.1152/jappl.2001.91.5.1999>
52. Sharp, D. S., Abbott, R. D., Burchfiel, C. M., Rodriguez, B. L., Tracy, R. P., Yano, K., Curb, J. D. (1996) Plasma fibrinogen and coronary heart disease in elderly JapaneseAmerican men. Arterioscler. Thromb. Vasc. Biol. 16, 262-268. <https://doi.org/10.1161/01.ATV.16.2.262>
53. Shiga, T., Maeda, N., Kon, K. (1990) Erythrocyte rheology. Crit. Rev. Oncol. Hematol. 10, 9-48. <https://doi.org/10.1016/1040-8428(90)90020-S>
54. Slater, T. F. (1984) Free-radical mechanisms in tissue injury. Biochem. J. 222, 1-15. <https://doi.org/10.1042/bj2220001>
55. Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D., Packer, L., Traber, M. G., Farese, R. V. Jr. (2000) Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E. Proc. Natl. Acad. Sci. USA 97, 13830-13834. <https://doi.org/10.1073/pnas.240462697>
56. Valacchi, G., Vasu, V. T., Yokohama, W., Corbacho, A. M., Phung, A., Lim, Y., Aung, H. H., Cross, C. E., Davis, P. A. (2007) Lung vitamin E transport processes are affected by both age and environmental oxidants in mice. Toxicol. Appl. Pharmacol. 222, 227-234. <https://doi.org/10.1016/j.taap.2007.04.010>
57. Wefers, H., Sies, H. (1988) The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. Eur. J. Biochem. 174, 353-357. <https://doi.org/10.1111/j.1432-1033.1988.tb14105.x>
58. Wojciech, Ł., Ewa, Z., Elzbieta, S. (2010) Influence of green tea on erythrocytes antioxidant status of different age rats intoxicated with ethanol. Phytother. Res. 24, 424-428. <https://doi.org/10.1002/ptr.2986>
59. Wray, D. W., Nishiyama, S. K., Monnet, A., Wary, C., Duteil, S. S., Carlier, P. G. Richardson, R. S. (2009) Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics. Am. J. Physiol. Heart Circ. Physiol. 297, H1870-5. <https://doi.org/10.1152/ajpheart.00709.2009>
60. Yerer, M. B., Aydogan, S. (2004) The in vivo antioxidant effectiveness of a-tocopherol in oxidative stress induced by sodium nitroprusside in rat red blood cells. Clin. Hemorheol. Microcirc. 30, 323-329.
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive