Fol. Biol. 2012, 58, 221-230

https://doi.org/10.14712/fb2012058060221

Efficient Generation of Induced Pluripotent Stem Cells from Human Bone Marrow Mesenchymal Stem Cells

X. Yulin, L. Lizhen, Z. Lifei, F. Shan, L. Ru, H. Kaimin, He Huang

Bone Marrow Transplantation Centre, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China

Received May 2012
Accepted August 2012

References

1. Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., Vallier, L., Gil, J. (2009) Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 23, 2134-2139. <https://doi.org/10.1101/gad.1811609>
2. Banito, A., Gil, J. (2010) Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep. 11, 353-359. <https://doi.org/10.1038/embor.2010.47>
3. Chou, B. K., Mali, P., Huang, X., Ye, Z., Dowey, S. N., Resar, L. M., Zou, C., Zhang, Y. A., Tong, J., Cheng, L. (2011) Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 21, 518-529. <https://doi.org/10.1038/cr.2011.12>
4. Esteban, M. A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., Pei, D. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71-79. <https://doi.org/10.1016/j.stem.2009.12.001>
5. Hanna, J. H., Saha, K., Jaenisch, R. (2010) Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell 143, 508-525. <https://doi.org/10.1016/j.cell.2010.10.008>
6. Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., Yamanaka, S. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135. <https://doi.org/10.1038/nature08235>
7. Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., Melton, D. A. (2008a) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotech. 26, 795-797. <https://doi.org/10.1038/nbt1418>
8. Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D.A. (2008b) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat. Biotech. 26, 1269-1275. <https://doi.org/10.1038/nbt.1502>
9. Jung, Y., Bauer, G., Nolta, J. A. (2012) Induced pluripotent stem cell-derived mesenchymal stem cells: progress toward safe clinical products. Stem Cells 30, 42-47. <https://doi.org/10.1002/stem.727>
10. Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., Izpisúa Belmonte, J. C. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140-1144. <https://doi.org/10.1038/nature08311>
11. Kim, J. B., Greber, B., Araúzo-Bravo, M. J., Meyer, J., Park, K. I., Zaehres, H., Schöler, H. R. (2009) Direct reprogramming of human neural stem cells by OCT4. Nature 461, 649-643. <https://doi.org/10.1038/nature08436>
12. Li, F., He, Z., Shen, J., Huang, Q., Li, W., Liu, X., He, Y., Wolf, F., Li, C. Y. (2010) Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell 7, 508-520. <https://doi.org/10.1016/j.stem.2010.09.003>
13. Mali, P., Chou, B.-K., Yen, J., Ye, Z., Zou, J., Dowey, S., Brodsky, R. A., Ohm, J. E., Yu, W., Baylin, S. B., Yusa, K., Bradley, A., Meyers, D. J., Mukherjee, C., Cole, P. A., Cheng, L. (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28, 713-720. <https://doi.org/10.1002/stem.402>
14. Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., Yamanaka, S. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotech. 26, 101-106. <https://doi.org/10.1038/nbt1374>
15. Niibe, K., Kawamura, Y., Araki, D., Morikawa, S., Miura, K., Suzuki, S., Shimmura, S., Sunabori, T., Mabuchi, Y., Nagai, Y., Nakagawa, T., Okano, H., Matsuzaki, Y. (2011) Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS ONE 6, e17610. <https://doi.org/10.1371/journal.pone.0017610>
16. Oda, Y., Yoshimura, Y., Ohnishi, H., Tadokoro, M., Katsube, Y., Sasao, M., Kubo, Y., Hattori, K., Saito, S., Horimoto, K., Yuba, S., Ohgushi, H. (2010) Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. J. Biol. Chem. 285, 29270-29278. <https://doi.org/10.1074/jbc.M109.055889>
17. Ohnishi, H., Oda, Y., Aoki, T., Tadokoro, M., Katsube, Y., Ohgushi, H., Hattori, K., Yuba, S. (2011) A comparative study of induced pluripotent stem cells generated from frozen, stocked bone marrowand adipose tissue-derived mesenchymal stem cells. J. Tissue Eng. Regen. Med. 6, 261-271. <https://doi.org/10.1002/term.428>
18. Okita, K., Ichisaka, T., Yamanaka, S. (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317. <https://doi.org/10.1038/nature05934>
19. Okita, K., Yamanaka, S. (2011) Induced pluripotent stem cells: opportunities and challenges. Phil. Trans. R. Soc. B 366, 2198-2207. <https://doi.org/10.1098/rstb.2011.0016>
20. Parekkadan, B., Milwid, J. M. (2010) Mesenchymal stem cells as therapeutics. Annu. Rev. Biomed. Eng. 12, 87-117. <https://doi.org/10.1146/annurev-bioeng-070909-105309>
21. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A,, Simonetti, D. W., Craig, S., Marshak, D. R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147. <https://doi.org/10.1126/science.284.5411.143>
22. Scheper, W., Copray, S. (2009) The molecular mechanism of induced pluripotency: A two-stage switch. Stem Cell Rev. 5, 204-223. <https://doi.org/10.1007/s12015-009-9077-x>
23. Takahashi, K., Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell 126, 663-676.
24. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. <https://doi.org/10.1016/j.cell.2007.11.019>
25. Thomas, E. D., Ashley, C. A., Lochte, H. L., Jaretzki, A., Sahler, O. D., Ferrebee, J. W. (1959) Homografts of bone marrow in dogs after lethal total-body radiation. Blood 14, 720-736. <https://doi.org/10.1182/blood.V14.6.720.720>
26. Unternaehrer, J. J., Daley, G. Q. (2011) Induced pluripotent stem cells for modelling human diseases. Phil. Trans. R. Soc. B 366, 2274-2285. <https://doi.org/10.1098/rstb.2011.0017>
27. Utikal, J., Polo, J. M., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J. G., Hochedlinger, K. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460, 1145-1148. <https://doi.org/10.1038/nature08285>
28. Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y. H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., Daley, G. Q., Brack, A. S., Collins, J. J., Cowan, C., Schlaeger, T. M., Rossi, D. J. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630. <https://doi.org/10.1016/j.stem.2010.08.012>
29. Yu, J., Vodyanik, M. A., Smuga-Otto, K., AntosiewiczBourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., Slukvin, II., Thomson, J. A. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920. <https://doi.org/10.1126/science.1151526>
30. Zhao, Y., Yin, X., Qin, H., Zhu, F., Liu, H., Yang, W., Zhang, Q., Xiang, C., Hou, P., Song, Z., Liu, Y., Yong, J., Zhang, P., Cai, J., Liu, M., Li, H., Li, Y., Qu, X., Cui, K., Zhang, W., Xiang, T., Wu, Y., Zhao, Y., Liu, C., Yu, C., Yuan, K., Lou, J., Ding, M., Deng, H. (2008) Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475-479. <https://doi.org/10.1016/j.stem.2008.10.002>
31. Zhou, H., Ding, S. (2010) Evolution of induced pluripotent stem cell technology. Curr. Opin. Hematol. 17, 276-280. <https://doi.org/10.1097/MOH.0b013e328339f2ee>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive